Age-related changes in female femoral neck geometry: Implications for bone strength

1993 ◽  
Vol 53 (S1) ◽  
pp. S41-S46 ◽  
Author(s):  
Thomas J. Beck ◽  
Christopher B. Ruff ◽  
Khem Bissessur
Keyword(s):  
Femoral Neck ◽  
Bone Strength ◽  
Age Related ◽  
Femoral Neck Geometry ◽  
Age Related Changes

scholarly journals Age-related changes in bone tissue in men

2021 ◽  
Vol 11 (2) ◽  
pp. 62-69
Author(s):  
A.S. Musiienko ◽  
N.V. Zaverukha
Keyword(s):  
Lumbar Spine ◽  
Femoral Neck ◽  
Bone Tissue ◽  
Clinical Signs ◽  
Osteoporotic Fractures ◽  
State Institution ◽  
Mineral Density ◽  
Healthy Men ◽  
Age Related ◽  
Age Related Changes

The purpose of the study was to establish age-related changes of male bone tissue. Materials and methods. The study was conducted by the Department of Clinical Physiology and Pathology of the Musculoskeletal System of the State Institution “D.F. Chebotarev Institute of Gerontology by the National Aca­demy of Medical Sciences of Ukraine”. It involved 342 healthy men aged 20 to 89 years without osteoporosis and osteoporotic fractures or any pathology with a confirmed impact on bone tissue, as well as any somatic pathology in the sub- and decompensation. The following methods of examination were used: questionnaire, anthropometric measurements, clinical and instrumental examination. Bone mineral density (BMD) was measured by the dual-energy X-ray absorptiometry machine “Prodigy, GEНС Lunar” at the level of the entire skeleton, lumbar spine (L1-L4), proximal femur and femoral neck, distal and ultra-distal forearm bones. Results. We have detected a significant 14.8 % decrease of BMD at the level of femoral neck in the group of men aged 60–69 years, by 20 % in the group of men aged 70–79 years, and by 24.1 % in the group of men aged 80–89 years compared to the men aged 20–29 years; at the same time, at the lumbar spine there was re­gistered a decrease of this parameter by 1.6 % in men aged 60–69 years, by 1.9 % in men of 70–79 years and by 0.8 % in men of 80–89 years, respectively. Among the examined practically healthy men, the bone tissue remained at the normal level relative to age in 67.8 %; osteopenia was detected in 27.8 %, and osteoporosis in 4.4 %. Conclusions. An age-associated BMD reduction was registered at various skeletal sites in the practically healthy men wi­thout any clinically significant factors affecting bone tissue metabolism. The most pronounced BMD loss was observed at the level of fe­moral neck. At the same time, 4.4 % of examined had osteoporosis without any clinical signs.

Age related changes in the bone microstructure in patients with femoral neck fractures

Injury ◽  
2020 ◽  
Vol 51 ◽  
pp. S12-S18 ◽  
Author(s):  
J.M. Sanchez-Siles ◽  
I. Tamimi-Mariño ◽  
A.R.G. Cortes ◽  
J.L. Ackerman ◽  
D. González-Quevedo ◽  
...  
Keyword(s):  
Femoral Neck ◽  
Bone Microstructure ◽  
Femoral Neck Fractures ◽  
Age Related ◽  
Age Related Changes

scholarly journals Age-Related Changes in Cortical Bone Content of Insulin-Like Growth Factor Binding Protein (IGFBP)-3, IGFBP-5, Osteoprotegerin, and Calcium in Postmenopausal Osteoporosis: A Cross-Sectional Study

2003 ◽  
Vol 88 (3) ◽  
pp. 1014-1018 ◽  
Author(s):  
Thor Ueland ◽  
Kim Brixen ◽  
Lis Mosekilde ◽  
Leif Mosekilde ◽  
Allan Flyvbjerg ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Femoral Neck ◽  
Cortical Bone ◽  
Postmenopausal Osteoporosis ◽  
Binding Protein ◽  
Guanidine Hydrochloride ◽  
Age Related ◽  
Igf I ◽  
Age Related Changes ◽  
Igfbp 3

Serum GH and IGF-I levels decline with increasing age, whereas osteoprotegerin (OPG) increases. IGFs as well as OPG are present in bone matrix and mediate the effects of many upstream hormones (e.g. estrogen). To evaluate whether changes in these proteins may to some extent explain the decrease in bone mass in postmenopausal or senile osteoporosis, we measured bone contents of IGF-I, IGF-II, IGF binding protein (IGFBP)-3, IGFBP-5, and OPG in combined extracts obtained after EDTA and guanidine hydrochloride extraction in 60 postmenopausal women aged 47–74 (mean, 63) yr with a previous distal forearm fracture and a hip or spine Z-score less than 0. We found age-related increases in IGFBP-3 (r = 0.35; P < 0.01), IGFBP-5 (r = 0.59; P < 0.001), and OPG (r = 0.36; P < 0.01) in cortical bone, significantly inversely correlated with femoral neck and lumbar spine BMD. A correlation between age and OPG was also detected in trabecular bone (r = 0.27; P < 0.05). A pronounced age-related decrease in cortical calcium contents (r = −0.60; P < 0.001), positively correlated with femoral neck and lumbar spine BMD, was also found. No age-related changes were detected for IGF-I or IGF-II. The present study demonstrates age-related changes in cortical bone contents of IGFBPs, calcium, and OPG, possibly related to the pathophysiology of postmenopausal osteoporosis. As for OPG, our findings probably represent compensatory responses to increased osteoclastic resorption.

Age-Related Changes in the Biochemical Properties of Human Cancellous Bone Collagen: Relationship to Bone Strength

1999 ◽  
Vol 65 (3) ◽  
pp. 203-210 ◽  
Author(s):  
A. J. Bailey ◽  
T. J. Sims ◽  
E. N. Ebbesen ◽  
J. P. Mansell ◽  
J. S. Thomsen ◽  
...  
Keyword(s):  
Bone Strength ◽  
Cancellous Bone ◽  
Biochemical Properties ◽  
Bone Collagen ◽  
Age Related ◽  
Human Cancellous Bone ◽  
Age Related Changes

scholarly journals Age-related changes in bone strength from HR-pQCT derived microarchitectural parameters with an emphasis on the role of cortical porosity

Bone ◽  
2016 ◽  
Vol 83 ◽  
pp. 233-240 ◽  
Author(s):  
Nicolas Vilayphiou ◽  
Stephanie Boutroy ◽  
Elisabeth Sornay-Rendu ◽  
Bert Van Rietbergen ◽  
Roland Chapurlat
Keyword(s):  
Bone Strength ◽  
Cortical Porosity ◽  
Age Related ◽  
Age Related Changes

scholarly journals Age-Related Changes in Trabecular and Cortical Bone Microstructure

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Huayue Chen ◽  
Xiangrong Zhou ◽  
Hiroshi Fujita ◽  
Minoru Onozuka ◽  
Kin-Ya Kubo
Keyword(s):  
Cortical Bone ◽  
Bone Strength ◽  
Elderly Population ◽  
Imaging Techniques ◽  
The Elderly ◽  
Bone Microstructure ◽  
Population Increase ◽  
Micro Ct ◽  
Age Related ◽  
Age Related Changes

The elderly population has substantially increased worldwide. Aging is a complex process, and the effects of aging are myriad and insidious, leading to progressive deterioration of various organs, including the skeleton. Age-related bone loss and resultant osteoporosis in the elderly population increase the risk for fractures and morbidity. Osteoporosis is one of the most common conditions associated with aging, and age is an independent risk factor for osteoporotic fractures. With the development of noninvasive imaging techniques such as computed tomography (CT), micro-CT, and high resolution peripheral quantitative CT (HR-pQCT), imaging of the bone architecture provides important information about age-related changes in bone microstructure and estimates of bone strength. In the past two decades, studies of human specimens using imaging techniques have revealed decreased bone strength in older adults compared with younger adults. The present paper addresses recently studied age-related changes in trabecular and cortical bone microstructure based primarily on HR-pQCT and micro-CT. We specifically focus on the three-dimensional microstructure of the vertebrae, femoral neck, and distal radius, which are common osteoporotic fracture sites.

scholarly journals Age-related changes of bone strength phenotypes: observational follow-up study of hand bone mineral density

2006 ◽  
Vol 1 (1-2) ◽  
pp. 59-68 ◽  
Author(s):  
I. Malkin ◽  
G. Bigman ◽  
R. Matias ◽  
L. Kalichman ◽  
M. J. Seibel ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Strength ◽  
Bone Mineral ◽  
Mineral Density ◽  
Follow Up Study ◽  
Age Related ◽  
Age Related Changes
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