Pharmacokinetics of polyvalent proteinase inhibitor (aprotinin) in eye tissues

1994 ◽  
Vol 85 (3) ◽  
pp. 275-280 ◽  
Author(s):  
N. B. Chesnokova ◽  
T. P. Kuznetsova ◽  
N. E. Sosulina
Keyword(s):  
Proteinase Inhibitor ◽  
Eye Tissues ◽  
Polyvalent Proteinase Inhibitor

Partition Coefficient of 133Xe between Blood and Eye Tissues

1975 ◽  
Vol 14 (04) ◽  
pp. 301-309
Author(s):  
A. Marczak ◽  
A. Moszczyńska-Kowalska ◽  
H. Kowalski
Keyword(s):  
Partition Coefficient ◽  
Aqueous Humour ◽  
Vitreous Body ◽  
Flow Measurements ◽  
Solubility Coefficient ◽  
Eye Muscles ◽  
Eye Tissues ◽  
Relative Solubility ◽  
Blood Flow Measurements

SummaryThe relative solubility coefficient of 133Xe and the tissue-blood partition coefficient for the aqueous humour vitreous body, conjunctiva and external eye muscles of the rabbit were determined in vitro at 37° C and at various haematocrit values. The partition coefficient for haematocrit 40 was: for the aqueous humour 0,49 ml/ml, for the vitreous body 0,50 ml/ml, for the conjunctiva 0,81 ml/g and for the external eye muscles 0,77 ml/g. It was found that the solubility of 133Xe in rabbit erythrocytes is about 50 per cent higher than that in human red cells. The consequences of this fact for the precision of blood flow measurements by the method of tissue clearance are discussed.

Some Properties of an Antiplasmin Substance from Rabbit Platelets

1970 ◽  
Vol 24 (01/02) ◽  
pp. 076-084 ◽  
Author(s):  
K Wakabayashi ◽  
K Fujikawa ◽  
T Abe
Keyword(s):  
Molecular Weight ◽  
Proteinase Inhibitor ◽  
Rabbit Platelets

SummaryRabbit platelets contained a proteinase inhibitor which inhibited plasmin, trypsin and chymotrypsin activities, and serum kallikrein to some extent. It did not inhibit pancreatic kallikrein and thrombin. It reacted stoechiometrically with these enzymes in a prompt fashion and was found to have a molecular weight of about 40,000.

Drusen in the Peripheral Retina of the Alzheimer’s Eye

2018 ◽  
Vol 15 (8) ◽  
pp. 743-750 ◽  
Author(s):  
Kresimir Ukalovic ◽  
Sijia Cao ◽  
Sieun Lee ◽  
Qiaoyue Tang ◽  
Mirza Faisal Beg ◽  
...  
Keyword(s):  
Peripheral Retina ◽  
Amyloid Angiopathy ◽  
Temporal Region ◽  
Future Studies ◽  
Eye Tissues ◽  
Neuropathological Diagnosis ◽  
Ocular Imaging ◽  
Cerebral Amyloid ◽  
The Brain ◽  
Oil Red O

Background: Recent work on Alzheimer's disease (AD) diagnosis focuses on neuroimaging modalities; however, these methods are expensive, invasive, and not available to all patients. Ocular imaging of biomarkers, such as drusen in the peripheral retina, could provide an alternative method to diagnose AD. Objective: This study compares macular and peripheral drusen load in control and AD eyes. Methods: Postmortem eye tissues were obtained from donors with a neuropathological diagnosis of AD. Retina from normal donors were processed and categorized into younger (<55 years) and older (>55 years) groups. After fixation and dissection, 3-6 mm punches of RPE/choroid were taken in macular and peripheral (temporal, superior, and inferior) retinal regions. Oil red O positive drusen were counted and grouped into two size categories: small (<63 μm) and intermediate (63-125 μm). Results: There was a significant increase in the total number of macular and peripheral hard drusen in older, compared to younger, normal eyes (p<0.05). Intermediate hard drusen were more commonly found in the temporal region of AD eyes compared to older normal eyes, even after controlling for age (p<0.05). Among the brain and eye tissues from AD donors, there was a significant relationship between cerebral amyloid angiopathy (CAA) severity and number of temporal intermediate hard drusen (r=0.78, p<0.05). Conclusion: Imaging temporal drusen in the eye may have benefit for diagnosing and monitoring progression of AD. Our results on CAA severity and temporal intermediate drusen in the AD eye are novel. Future studies are needed to further understand the interactions among CAA and drusen formation.

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