Concentration and protein binding of cephalosporins in renal interstitial fluid, soft-tissue interstitial fluid, urine and serum

Infection ◽  
1978 ◽  
Vol 6 (S2) ◽  
pp. S233-S237 ◽  
Author(s):  
H. -U. Eickenberg
Keyword(s):  
Soft Tissue ◽  
Protein Binding ◽  
Interstitial Fluid ◽  
Tissue Interstitial Fluid ◽  
Urine And Serum

Concentration of antibiotics in renal interstitial fluid, soft tissue interstitial fluid, urine and serum

Infection ◽  
1976 ◽  
Vol 4 (S2) ◽  
pp. S97-S104 ◽  
Author(s):  
H. -U. Eickenberg ◽  
L. Scharfenberger ◽  
N. G. Waterman
Keyword(s):  
Soft Tissue ◽  
Interstitial Fluid ◽  
Tissue Interstitial Fluid ◽  
Urine And Serum

Quantification of Basal Insulin Peglispro and Human Insulin in Adipose Tissue Interstitial Fluid by Open-Flow Microperfusion

2017 ◽  
Vol 19 (5) ◽  
pp. 305-314 ◽  
Author(s):  
Katrin Tiffner ◽  
Beate Boulgaropoulos ◽  
Christian Höfferer ◽  
Thomas Birngruber ◽  
Niels Porksen ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Human Insulin ◽  
Basal Insulin ◽  
Interstitial Fluid ◽  
Open Flow ◽  
Tissue Interstitial Fluid

scholarly journals Single-dose pharmacokinetics of temocillin in plasma and soft tissues of healthy volunteers after intravenous and subcutaneous administration: a randomized crossover microdialysis trial

2020 ◽  
Vol 75 (9) ◽  
pp. 2650-2656 ◽  
Author(s):  
Peter Matzneller ◽  
Perrin Ngougni Pokem ◽  
Arnaud Capron ◽  
Edith Lackner ◽  
Beatrix Wulkersdorfer ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Protein Binding ◽  
Healthy Volunteers ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Soft Tissues ◽  
Therapeutic Option ◽  
Subcutaneous Administration ◽  
Intravenous Route ◽  
Drug Concentrations

Abstract Background The antibiotic temocillin has recently been rediscovered as a promising therapeutic option against MDR Gram-negative bacteria. However, some aspects of the pharmacokinetic (PK) profile of the drug are still to be elucidated: subcutaneous administration of temocillin might be of interest as an alternative to the intravenous route in selected patients. Similarly, information on the penetration of temocillin into human soft tissues is lacking. Objectives To investigate the feasibility and plasma PK of subcutaneous dosing as well as soft tissue PK of temocillin after intravenous administration to healthy volunteers. Methods Eight healthy volunteers received 2 g of temocillin both as intravenous and subcutaneous infusion in a randomized two-period crossover study. Concentration–time profiles of total temocillin in plasma (after both routes) and of unbound temocillin in plasma, muscle and subcutis (only after intravenous dosing) were determined up to 12 h post-dose. Results Subcutaneous dosing caused some infusion site discomfort but resulted in sustained drug concentrations over time with only slightly decreased overall exposure compared with intravenous dosing. Plasma protein binding of temocillin showed concentration-dependent behaviour and was higher than previously reported. Still, unbound drug concentrations in muscle and subcutis determined by microdialysis markedly exceeded those in plasma, suggesting good tissue penetration of temocillin. Conclusions The subcutaneous administration of temocillin is a valid and feasible alternative to intravenous dosing. With the description of plasma protein binding and soft tissue PK of temocillin in healthy volunteers, this study provides important information that adds to the ongoing characterization of the PK profile of temocillin and might serve as input for PK/PD considerations.

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