Assessment of the relationship between broadband ultrasound attenuation and bone mineral density at the calcaneus using BUA imaging and DXA

1997 ◽  
Vol 7 (4) ◽  
pp. 316-322 ◽  
Author(s):  
C. Chappard ◽  
P. Laugier ◽  
B. Fournier ◽  
C. Roux ◽  
G. Berger
Author(s):  
S-M Han ◽  
J-Y Rho

The effect of trabecular elastic anisotropy on broadband ultrasound attenuation (BUA) and bone mineral density (BMD) was investigated with human and bovine cubic cancellous bones. Ultrasonic parameters describing trabecular anisotropy were found from the three orthogonal ultrasound velocities. BMD was measured using quantitative computed tomography. Three elastic anisotropy ratios were compared to BUA in all three directions and to BMD. The combined effect of anisotropic characteristics and BMD was also correlated with BUA. The results showed that the anisotropy ratios were significantly related to BUA (p<0.05). There was, however, no correlation between BMD and the elastic anisotropy ratios. The combination of BMD and the anisotropy produced a significantly enhanced relationship with BUA.


2021 ◽  
Author(s):  
Bisma Rizvi

Dual-energy x-ray absorptiometry (DXA) is the current gold standard method used for the diagnosis of osteoporosis. However, it is well-established that the presence of strontium in bone could lead to significant error in measurement of bone mineral density (BMD) and diagnosis of osteoporosis using DXA. The objectives of this study are: (1) to develop novel bone-mimicking phantoms containing different concentrations of strontium, and (2) to investigate the effect of bone strontium content on the BMD measurement using quantitative ultrasound (QUS) technique. Measurements using the research and clinical QUS systems showed a strong dependency of the BUA (broadband ultrasound attenuation) of the medium with the BMD. Moreover, increasing strontium concentrations in bone phantoms of up to 3 mol% strontium showed no effect on the BUA or the SOS values measured with either system. Therefore, the QUS technique is independent of level of bone strontium of up to 3 mol/mol [Sr/(Sr+Ca)] %.


2021 ◽  
Author(s):  
Bisma Rizvi

Dual-energy x-ray absorptiometry (DXA) is the current gold standard method used for the diagnosis of osteoporosis. However, it is well-established that the presence of strontium in bone could lead to significant error in measurement of bone mineral density (BMD) and diagnosis of osteoporosis using DXA. The objectives of this study are: (1) to develop novel bone-mimicking phantoms containing different concentrations of strontium, and (2) to investigate the effect of bone strontium content on the BMD measurement using quantitative ultrasound (QUS) technique. Measurements using the research and clinical QUS systems showed a strong dependency of the BUA (broadband ultrasound attenuation) of the medium with the BMD. Moreover, increasing strontium concentrations in bone phantoms of up to 3 mol% strontium showed no effect on the BUA or the SOS values measured with either system. Therefore, the QUS technique is independent of level of bone strontium of up to 3 mol/mol [Sr/(Sr+Ca)] %.


Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 938
Author(s):  
Jian Geng ◽  
Ling Wang ◽  
Qing Li ◽  
Pengju Huang ◽  
Yandong Liu ◽  
...  

Little is known about the effect of lumbar intervertebral disc herniation (LDH) on lumbar bone mineral density (BMD), and few previous studies have used quantitative computed tomography (QCT) to assess whether the staging of LDH correlates with lumbar vertebral trabecular volumetric bone mineral density (Trab.vBMD). To explore the relationship between lumbar Trab.vBMD and LDH, seven hundred and fifty-four healthy participants aged 20–60 years were enrolled in the study from an ongoing study on the degeneration of the spine and knee between June 2014 and 2017. QCT was used to measure L2–4 Trab.vBMD and lumbar spine magnetic resonance images (MRI) were performed to assess the incidence of disc herniation. After 9 exclusions, a total of 322 men and 423 women remained. The men and women were divided into younger (age 20–39 years) and older (age 40–60 years) groups and further into those without LDH, with a single LDH segment, and with ≥2 segments. Covariance analysis was used to adjust for the effects of age, BMI, waistline, and hipline on the relationship between Trab.vBMD and LDH. Forty-one younger men (25.0%) and 59 older men (37.3%) had at least one LDH segment. Amongst the women, the numbers were 46 (22.5%) and 80 (36.4%), respectively. Although there were differences in the characteristics data between men and women, the difference in Trab.vBMD between those without LDH and those with single and ≥2 segments was not statistically significant (p > 0.05). These results remained not statistically significant after further adjusting for covariates (p > 0.05). No associations between lumbar disc herniation and vertebral trabecular volumetric bone mineral density were observed in either men or women.


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