Effects of 5-hydroxytryptamine and adenosine on the canine isolated cerebral resistance vessels

2011 ◽  
Vol 7 (01) ◽  
pp. 34-40 ◽  
Author(s):  
Youji Ohigashi ◽  
Y. Kawai ◽  
J. Wang ◽  
T. Ohhashi
Keyword(s):  
Resistance Vessels ◽  
Cerebral Resistance

Hyperthermia increases cerebral metabolic rate and blood flow in neonatal pigs

1988 ◽  
Vol 255 (2) ◽  
pp. H343-H346 ◽  
Author(s):  
D. W. Busija ◽  
C. W. Leffler ◽  
M. Pourcyrous
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Metabolic Rate ◽  
Intravenous Injection ◽  
Neonatal Pigs ◽  
Cerebral Metabolic Rate ◽  
Resistance Vessels ◽  
Newborn Pigs ◽  
Cerebral Resistance

We examined effects of hyperthermia on cerebral metabolic rate for oxygen (CMRO2) and cerebral blood flow (CBF) in anesthetized, newborn pigs (2–5 days old). CBF and CMRO2 were measured during normothermia (38 degrees C) and during hyperthermia induced by body heating (42 degrees C). During normothermia, total CBF was 32 +/- 3 ml.min-1.100 g-1 (n = 9), and CMRO2 was 1.34 +/- 0.08 ml O2.100 g-1.min-1 (n = 7). During hyperthermia, total CBF increased by 97 +/- 23% and CMRO2 by 65 +/- 24%. We also examined whether cerebral resistance vessels were responsive under these conditions. During hyperthermia, total CBF was 63 +/- 6 ml.min-1.100 g-1, and CMRO2 was 2.13 +/- 0.27 ml O2.100 g-1.min-1. During sustained hyperthermia, intravenous injection of 5 mg/kg of indomethacin decreased total CBF by 45 +/- 7% (n = 9), and CMRO2 fell by 55 +/- 10% (n = 5). We conclude that 1) hyperthermia increases CBF and CMRO2, and 2) the dilated cerebrovascular bed during hyperthermia still is responsive to a constrictor stimulus.

SODIUM NITROPRUSSIDE DOES NOT DILATE CEREBRAL RESISTANCE VESSELS DURING HYPOTHERMIC CARDIOPULMONARY BYPASS

1990 ◽  
Vol 70 (Supplement) ◽  
pp. S327
Author(s):  
A T Rogers ◽  
D S Prough ◽  
S A Mills ◽  
D A Stump ◽  
J Phipps ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Sodium Nitroprusside ◽  
Hypothermic Cardiopulmonary Bypass ◽  
Resistance Vessels ◽  
Cerebral Resistance

Sodium Nitroprusside Infusion Does Not Dilate Cerebral Resistance Vessels during Hypothermic Cardiopulmonary Bypass

1991 ◽  
Vol 74 (5) ◽  
pp. 820-826 ◽  
Author(s):  
Anne T. Rogers ◽  
Donald S. Prough ◽  
Glenn P. Gravlee ◽  
Raymond C. Roy ◽  
Stephen A. Mills ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Sodium Nitroprusside ◽  
Hypothermic Cardiopulmonary Bypass ◽  
Resistance Vessels ◽  
Cerebral Resistance ◽  
Nitroprusside Infusion

scholarly journals Cerebral Blood Flow Autoregulation in Acute Intracranial Hypertension

1994 ◽  
Vol 14 (3) ◽  
pp. 519-525 ◽  
Author(s):  
John Hauerberg ◽  
Marianne Juhler
Keyword(s):  
Intracranial Hypertension ◽  
Ringer Solution ◽  
Significant Shift ◽  
Arterial Blood ◽  
Resistance Vessels ◽  
Acute Elevation ◽  
Series Of Experiments ◽  
Low Levels ◽  
Cerebral Resistance ◽  
Increased Icp

The present series of experiments was carried out to investigate CBF autoregulation during fixed levels of acute increased intracranial pressure (ICP). Three groups of six rats each, one with normal ICP (8 mm Hg), one with moderately increased ICP (30 mm Hg), and one with severely increased ICP (50 mm Hg), were investigated. ICP was maintained by continuous infusion of lactated Ringer solution into the cisterna magna. Cerebral perfusion pressure (CPP), calculated as mean arterial blood pressure – ICP, was increased by intravenously infused norepinephrine and decreased by controlled bleeding. In all groups the corresponding autoregulation curve included a plateau where CBF was independent of changes in CPP, demonstrating intact autoregulation. However, a significant shift of the lower limit of autoregulation (LL) toward lower CPP levels during severe intracranial hypertension was observed (p < 0.006). In the controls the LL was found at CPP = 73 ±6 mm Hg, in moderately increased ICP the LL was 59 ± 4 mm Hg, and in severely increased ICP the LL was 51 ±4 mm Hg. These results indicate that an acute elevation of ICP activates a reserve capacity of cerebral resistance vessels that dilate further below the normal physiological LL to maintain CBF at low levels of CPP.

Valsalva maneuver suggests increased rigidity of cerebral resistance vessels in familial dysautonomia

2002 ◽  
Vol 12 (5) ◽  
pp. 385-392 ◽  
Author(s):  
M. J. Hilz ◽  
F. B. Axelrod ◽  
M. Steingrueber ◽  
B. Stemper
Keyword(s):  
Valsalva Maneuver ◽  
Familial Dysautonomia ◽  
Resistance Vessels ◽  
Cerebral Resistance

Beneficial Morphofunctional Changes Promoted by Sildenafil in Resistance Vessels in the Angiotensin II-Induced Hypertension Model

2018 ◽  
Vol 19 (6) ◽  
pp. 483-494 ◽  
Author(s):  
Ananda T. Dias ◽  
Marcos A.S. Leal ◽  
Tadeu C. Zanardo ◽  
Gisele M. Alves ◽  
Marcella L. Porto ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Resistance Vessels ◽  
Induced Hypertension

Peptidergic control of coronary resistance vessels

2011 ◽  
Author(s):  
György L. Nádasy ◽  
Mária Szekeres ◽  
Balázs Sachs ◽  
Violetta Kékesi ◽  
László Hunyady ◽  
...  
Keyword(s):  
Coronary Resistance ◽  
Resistance Vessels
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