In vitro bone resorption by isolated multinucleated giant cells from giant cell tumour of bone: Light and electron microscopic study

1991 ◽  
Vol 419 (4) ◽  
pp. 327-338 ◽  
Author(s):  
Junya Kanehisa ◽  
Toshiyuki Izumo ◽  
Mikio Takeuchi ◽  
Takeshi Yamanaka ◽  
Teruhisa Fujii ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Giant Cell ◽  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Giant Cell Tumour ◽  
Giant Cells ◽  
Cell Tumour ◽  
Multinucleated Giant Cells ◽  
Electron Microscopic

Osteoclast-like giant cell tumour arising from the kidney in a dog

2005 ◽  
Vol 53 (2) ◽  
pp. 225-230 ◽  
Author(s):  
R. Haziroglu ◽  
O. Kul ◽  
R. Tunca ◽  
T. Guvenc
Keyword(s):  
Connective Tissue ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Left Kidney ◽  
Giant Cells ◽  
Osteoblastic Differentiation ◽  
Cell Tumour ◽  
Immunoperoxidase Staining ◽  
Multinucleated Giant Cells ◽  
Visceral Organ

In this study, a case of osteoclast-like giant cell tumour arising from the kidney is reported in an eight-year-old female Anatolian Shepherd dog. Macroscopically, the tumorous mass covered the hilus of the left kidney. It was 26×22×12 cm in size and 3700 g in weight. Metastatic tumorous nodules, 0.5-2.0 cm in diameter, were found on the abdominal side of the diaphragm and in the lungs. Microscopically, numerous large osteoclast-like multinucleated giant cells and spindle-spheroidal-shaped cells were seen. Osteoblastic differentiation and osteoid matrix were noted in a few areas at the periphery of the tumour, near the connective tissue septa. The stroma of the tumour tissue was vascular, oedematous and loose. By immunoperoxidase staining, tumour cells showed immunoreactivity for vimentin but not for keratin and desmin, indicating that the tumour had mesenchymal origin. This is the first report in the literature on a malignant osteoclast-like giant cell tumour arising from a visceral organ in animals.

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