Effects of mutations altering SOS regulation on a nalidixic acid-inducible system for the production of heterologous proteins inEscherichia coli

1990 ◽  
Vol 6 (3) ◽  
pp. 199-206
Author(s):  
J. Keller ◽  
R. Gerber ◽  
B. J. Tito ◽  
D. Vannicolo ◽  
E. J. Arcuri
Keyword(s):  
Nalidixic Acid ◽  
Inescherichia Coli ◽  
Heterologous Proteins

Constitutive versus thermoinducible expression of heterologous proteins inEscherichia coli based on strong PR,PL promoters from phage lambda

2003 ◽  
Vol 83 (2) ◽  
pp. 181-190 ◽  
Author(s):  
Viktor Menart ◽  
Simona Jev?evar ◽  
Mateja Vilar ◽  
Andreja Trobi? ◽  
Aleksander Pavko
Keyword(s):  
Inescherichia Coli ◽  
Heterologous Proteins ◽  
Phage Lambda

Versatile signal peptide ofFlavobacterium-originated organophosphorus hydrolase for efficient periplasmic translocation of heterologous proteins inEscherichia coli

2016 ◽  
Vol 32 (4) ◽  
pp. 848-854 ◽  
Author(s):  
Dong Gyun Kang ◽  
Jeong Hyun Seo ◽  
Byung Hoon Jo ◽  
Chang Sup Kim ◽  
Suk Soon Choi ◽  
...  
Keyword(s):  
Signal Peptide ◽  
Organophosphorus Hydrolase ◽  
Inescherichia Coli ◽  
Heterologous Proteins

ANTIMICROBIAL SUSCEPTIBILITY IN CULTURE POSITIVE ENTERIC FEVER

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Dr. Manish Kulshrestha ◽  
Dr. Anjali Kulshrestha
Keyword(s):  
Bone Marrow ◽  
Blood Culture ◽  
Nalidixic Acid ◽  
Antimicrobial Susceptibility ◽  
Salmonella Enterica ◽  
Enteric Fever ◽  
Multidrug Resistant ◽  
Bone Marrow Culture ◽  
Diffusion Method ◽  
Culture Positive

INTRODUCTION: Enteric fever includes typhoid and paratyphoid fever. Peak incidence is seen in children 5–15 years of age; but in regions where the disease is highly endemic, as in India, children younger than 5 years of age may have the highest infection rates. There are about 22 million new typhoid cases occur each year. Young children in poor, resource limited areas, who make up the majority of the new cases and there is a mortality figures of 215,000 deaths annually. A sharp decline in the rates of complications and mortality due to typhoid fever is observed as a result of introduction of effective antibiotic therapy since 1950s. MDR-ST became endemic in many areas of Asia, including India soon after multidrug-resistant strains of Salmonella enterica serotype typhi (MDR-ST) that were resistant to all the three first-line drugs then in use, namely chloramphenicol, amoxycillin and co-trimoxazole emerged in early 1990s. MATERIAL AND METHODS: Only blood culture or bone marrow culture positive cases were included. The patients with culture isolated enteric fever were included in the study. Antimicrobial susceptibility testing was carried out by disk diffusion method using antibiotic discs. The analysis of the antimicrobial susceptibility was carried out as per CLSI interpretative guidelines. RESULTS: A total of 82 culture positive cases were included in the present study. 80 culture isolates were from blood culture and 2 from the bone marrow culture. Salmonella entericasubspecies enterica serovartyphi (S typhi) was isolated from 67 (81.70%) patients while Salmonella enterica subspecies entericaserovarparatyphi (S paratyphi A) was isolated from 13 (15.85%) cases and 2 (2.44%) were Salmonella enterica subspecies entericaserovarschottmuelleri (S paratyphi B). Of the 82 cases 65(79.3%) isolates were resistant to ciprofloxacin, 17 (20.7%) were resistant to nalidixic acid, one (1.2%) case each was resistant to Cefotaxime and ceftriaxone, 2 (2.4%) were resistant to chloramphenicol, 10 (12.2%) were resistant and to cotrimoxazole 3 (3.7%) were resistant. CONCLUSION: In a culture positive cases 65(79.3%) isolates were resistant to ciprofloxacin and 17 (20.7%) were resistant to nalidixic acid. Multidrug resistant isolates were 65(79.3%).

Synthesis, characterization and biological activities of 1,3,4-oxadiazole derivatives of nalidixic acid and their copper complexes

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Nalidixic Acid ◽  
Copper Complexes ◽  
Biological Activities ◽  
Bidentate Coordination ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Oxadiazole Derivatives ◽  
Antibacterial And Antifungal ◽  
Derivatives Of ◽  
Substituted 1

A series of novel 1, 3, 4-oxadiazole analogues was synthesized from cyclization of hydrazones of substituted 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carbohydrazides were prepared from nalidixic acid. The structures of synthesized oxadiazole derivatives and their copper complexes were elucidated on the basis of FTIR, elemental analyses, 1H-NMR and atomic absorption spectral analysis. It was observed from spectral data that metal ligand ratio was 1:1 in all copper complexes and they were bidentate, coordination was found to be done through oxygen of 4-oxo group and nitrogen of oxadiazole ring. The synthesized compounds were further evaluated with biological activities and compared with parent hydrazones. Copper complexes possess antibacterial and antifungal activities better than the oxadiazoles while they have better antioxidant activity then copper complexes. Parent hydrazones were better in all biological activities than synthesized oxadiazoles.

Nalidixic Acid Schiff bases: Synthesis and Biological Evaluation

2017 ◽  
Vol 14 ◽  
Author(s):  
Asif Husain ◽  
Munendra Mohan Varshney ◽  
Versha Parcha ◽  
Aftab Ahmad ◽  
Shahalam Khan
Keyword(s):  
Nalidixic Acid ◽  
Schiff Bases ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation
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