Fatty acid control of cyclic AMP levels inNeurospora crassa

1987 ◽  
Vol 15 (1) ◽  
pp. 25-27
Author(s):  
Martin L. Pall ◽  
Carla K. Robertson
Keyword(s):  
Fatty Acid ◽  
Cyclic Amp ◽  
Acid Control ◽  
Inneurospora Crassa

scholarly journals Clearing-factor lipase in adipose tissue. A possible role of adenosine 3′,5′-(cyclic)-monophosphate in the regulation of its activity

1968 ◽  
Vol 109 (5) ◽  
pp. 841-849 ◽  
Author(s):  
D. R. Wing ◽  
D S Robinson
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Cyclic Amp ◽  
Lipase Activity ◽  
Glucose Concentration ◽  
Free Fatty Acid Concentration ◽  
Epididymal Fat ◽  
Fat Bodies

1. The rise in clearing-factor lipase activity that occurs when epididymal fat bodies from starved rats are incubated in appropriate media in vitro is inhibited in the presence of 6-N-2′-O-dibutyryl-3′,5′-(cyclic)-AMP (1mm). 2. Inhibition occurs at a concentration of glucose in the incubation medium of 1·3mg./ml. or less, but not at a glucose concentration of 2·4mg./ml., unless caffeine (1mm), an inhibitor of 3′,5′-(cyclic)-nucleotide phosphodiesterase, is also present. Caffeine (5mm) alone inhibits the rise in clearing-factor lipase activity at a glucose concentration of 2·4mg./ml. of medium. 3. The concentration of free fatty acids in the epididymal fat bodies normally falls during incubations in vitro as the rise in clearing-factor lipase activity occurs. In the presence of 1mm-6-N-2′-O-dibutyryl-3′,5′-(cyclic)-AMP, however, either the tissue free fatty acid concentration is increased or it does not fall to the same extent. The concentration of glucose in the incubation medium is important in determining the direction and extent of the changes in tissue free fatty acid concentration that occur in the presence of 6-N-2′-O-dibutyryl-3′,5′-(cyclic)-AMP. 4. Free fatty acid concentrations in epididymal fat bodies in vivo rise as the clearing-factor lipase activity of the tissue falls during starvation. 5. The possibility that the concentration of 3′,5′-(cyclic)-AMP in adipose tissue may regulate clearing-factor lipase activity, and that the regulation may occur through effects of the nucleotide on tissue free fatty acid concentrations, is discussed.

scholarly journals Fatty acid control of growth of human cervical and endometrial cancer cells

1990 ◽  
Vol 61 (4) ◽  
pp. 500-503 ◽  
Author(s):  
RP Gleeson ◽  
M Ayub ◽  
JT Wright ◽  
CB Wood ◽  
NA Habib ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Fatty Acid ◽  
Cancer Cells ◽  
Acid Control

Loss of fatty acid control of gluconeogenesis and PDH complex flux in adrenalectomized rats

1994 ◽  
Vol 267 (4) ◽  
pp. E528-E536 ◽  
Author(s):  
G. Cipres ◽  
E. Urcelay ◽  
N. Butta ◽  
M. S. Ayuso ◽  
R. Parrilla ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Pyruvate Dehydrogenase ◽  
Pyruvate Dehydrogenase Complex ◽  
Reducing Power ◽  
Acid Control ◽  
Body Production ◽  
Rat Livers ◽  
Complex Flux ◽  
Dehydrogenase Complex

This work aimed to determine the role played by the adrenal gland in the fatty acid control of gluconeogenesis in isolated perfused rat livers. The gluconeogenic substrate concentration responses were not altered in adrenalectomized (ADX) rats. This observation indicates that glucocorticoids are not essential to maintain normal basal gluconeogenic rates. In contrast, fatty acid failed to stimulate gluconeogenesis from lactate and elicited attenuated stimulation with pyruvate as substrate in livers from ADX rats. Fatty acid-induced stimulation of respiration and ketone body production were similar in control and ADX rats. Thus the diminished responsiveness of the gluconeogenic pathway to fatty acid cannot be the result of different rates of energy production and/or generation of reducing power. Fatty acids did not inhibit pyruvate decarboxylation in livers from ADX rats. Even though mitochondria isolated from livers of ADX rats showed normal basal rates of pyruvate metabolism, fatty acids failed to inhibit pyruvate decarboxylation and the activity of the pyruvate dehydrogenase complex. This novel observation of the glucocorticoid effect in controlling the pyruvate dehydrogenase complex responsiveness indicates that the mitochondrial partitioning of pyruvate between carboxylation and decarboxylation reactions may be altered in livers from ADX rats. We propose that the diminished effect of fatty acid in stimulating gluconeogenesis in livers from ADX rats is the result of a limited pyruvate availability for the carboxylase reaction due to a lack of inhibition of flux through the pyruvate dehydrogenase complex.

scholarly journals Correction: Cyclic AMP-dependent protein lysine acylation in mycobacteria regulates fatty acid and propionate metabolism

2019 ◽  
Vol 294 (28) ◽  
pp. 11046-11046
Author(s):  
Subhalaxmi Nambi ◽  
Kallol Gupta ◽  
Moitrayee Bhattacharyya ◽  
Parvathy Ramakrishnan ◽  
Vaishnavi Ravikumar ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cyclic Amp ◽  
Propionate Metabolism ◽  
Dependent Protein

Propranolol Inhibits Bile Acid and Fatty Acid Stimulation of Cyclic AMP in Human Colon

1977 ◽  
Vol 73 (5) ◽  
pp. 971-974 ◽  
Author(s):  
M.J. Coyne ◽  
G.G. Bonorris ◽  
A. Chung ◽  
D. Conley ◽  
L.J. Schoenfield
Keyword(s):  
Fatty Acid ◽  
Bile Acid ◽  
Cyclic Amp ◽  
Human Colon ◽  
Stimulation Of

The Effect of Antilipolytic Agents on Cyclic AMP, Free Fatty Acid and Total Catecholamine Concentrations in Plasma

2009 ◽  
Vol 199 (1-6) ◽  
pp. 421-424 ◽  
Author(s):  
R. C. Strange ◽  
M. J. Rowe ◽  
O. D. Mjøs ◽  
M. F. Oliver
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Cyclic Amp
Sign in / Sign up

Export Citation Format

Share Document