Intracranial meningiomas in the elderly (over 70 years old)

1988 ◽  
Vol 90 (3-4) ◽  
pp. 121-123 ◽  
Author(s):  
M. Djindjian ◽  
J. P. Caron ◽  
A. A. Athayde ◽  
M. J. Février
Keyword(s):  
The Elderly ◽  
Intracranial Meningiomas

scholarly journals Clinical features and surgical management of intracranial meningiomas in the elderly

2017 ◽  
Vol 14 (1) ◽  
pp. 909-917 ◽  
Author(s):  
Junkoh Yamamoto ◽  
Mayu Takahashi ◽  
Masaru Idei ◽  
Yoshiteru Nakano ◽  
Yoshiteru Soejima ◽  
...  
Keyword(s):  
Clinical Features ◽  
Surgical Management ◽  
The Elderly ◽  
Intracranial Meningiomas

Intracranial meningiomas in the elderly. A reappraisal

Neurocirugía ◽  
1992 ◽  
Vol 3 (1) ◽  
pp. 23-29 ◽  
Author(s):  
M. Clavel ◽  
F. Gómez-Taborga ◽  
P. Tresserras ◽  
R. Dinares ◽  
J. Homedo
Keyword(s):  
The Elderly ◽  
Intracranial Meningiomas

Intracranial Meningiomas in the Elderly

2017 ◽  
pp. 97-117
Author(s):  
David B. Schul ◽  
Chochlidakis Nikos ◽  
Chirstianto B. Lumenta
Keyword(s):  
The Elderly ◽  
Intracranial Meningiomas

Intracranial Meningiomas in the Aged: Surgical Outcome in the Era of Computed Tomography

Neurosurgery ◽  
1989 ◽  
Vol 24 (4) ◽  
pp. 557-560 ◽  
Author(s):  
Issam A. Awad ◽  
Iain Kalfas ◽  
Joseph F. Awad ◽  
John R. Awad
Keyword(s):  
Tumor Size ◽  
Surgical Outcome ◽  
The Elderly ◽  
Neurological Status ◽  
Tumor Location ◽  
Morbidity And Mortality ◽  
Perioperative Morbidity ◽  
Intracranial Meningiomas ◽  
Group A ◽  
Group B

ABSTRACT Seventy-five patients older than 60 years of age underwent surgical resection of intracranial meningiomas during a 10-year period at a single institution. All patients had a computed tomographic scan preoperatively, and all were followed for at least 3 months postoperatively. There were 50 patients 61 to 70 years of age (Group A), and 25 patients older than 70 years (Group B). Sixteen patients (21%) were asymptomatic, and no patient was severely disabled preoperatively. Operative morbidity and mortality and outcome at 3 months were assessed and correlated with age, preoperative neurological status, and tumor size and location. Operative mortality was 6.6% (6% in Group A; 8% in Group B). Perioperative morbidity (including medical and surgical complications and worsening in neurological status) was 48% (46% in Group A; 52% in Group B). Neurological status 3 months after surgery was improved by at least one grade as compared to before surgery in 40% of patients (38% in Group A; 44% in Group B), unchanged in 29% (34% in Group A; 20% in Group B), and worsened in 31% (28% in Group A; 36% in Group B). While nearly half of the patients were asymptomatic 3 months after surgery, 11 patients (15%) had died or remained seriously disabled. Outcome at 3 months correlated significantly with low neurological grade preoperatively and with a tumor location over the cortical convexity. There was no significant correlation with age or tumor size. We conclude that resection of intracranial meningiomas is associated with significant morbidity and mortality in the elderly. Figures from large series of mostly younger patients with meningiomas do not reflect surgical outcome in the aged. The best outcome is seen in patients who do not have advanced neurological symptoms preoperatively and in patients with meningioma location in the cortical convexity.

scholarly journals Intracranial Meningiomas in the Elderly: Clinical, Surgical and Economic Evaluation. A Multicentric Experience

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2685
Author(s):  
Delia Cannizzaro ◽  
Maria Pia Tropeano ◽  
Ismail Zaed ◽  
Mario De Robertis ◽  
Simone Olei ◽  
...  
Keyword(s):  
Complication Rate ◽  
The Elderly ◽  
Patient Specific ◽  
Karnofsky Performance Scale ◽  
Intracranial Meningioma ◽  
Surgical Timing ◽  
Intracranial Meningiomas ◽  
Combined Strategy ◽  
Clinical Conditions

Meningioma is one of the most common intracranial tumors. It is benign and slow growing in the majority of cases. Given the increase in life expectancy and the number of radiological tests performed, the incidence in the elderly population (≥65 years) is continuously increasing. The surgical outcomes and prognostic factors in this age group are unclear. A retrospective analysis of all the patients treated for intracranial meningiomas in two different Italian institutions was performed. The clinical, radiological, surgical and follow-up data were retrospectively reviewed. Statistical analyses were performed to identify relationships between factors and outcomes. We also carried out an economic analysis. We analyzed 321 patients with intracranial meningioma. The mean age was 72.6 years (range, 65–90), with a female predominance (F/M, 1.41). Pre-operative deficits, cognitive impairment and seizures (p < 0.001) were associated with a worse post-operative Karnofsky performance scale (KPS) score (<80). A high pre-operative KPS score was associated with a good clinical and neurological outcome (p < 0.001). Being aged between 65 and 74 years, low surgical timing and Simpson removal grades of I and II were associated with a good outcome (p < 0.001). The length of hospitalization was significantly related to the outcome (p < 0.001). The complication rate was 14.3%. At 6-month follow-up, the mortality rate was 2.5%. The average cost was higher in patients with a pre-operative KPS score lower than 80. The outcome of intracranial-meningioma resection in elderly individuals is favorable when the pre-operative KPS score is >80. Treatment should be patient-specific, and additional factors should be considered. Patients with poor pre-operative clinical conditions might benefit from a combined strategy with partial resection and radiosurgery in order to reduce surgical timing and the complication rate.

scholarly journals P09.02 Surgical treatment for intracranial meningiomas in elderly patients growing during follow-up study

2019 ◽  
Vol 21 (Supplement_3) ◽  
pp. iii39-iii39
Author(s):  
M Okuma
Keyword(s):  
Surgical Treatment ◽  
Life Expectancy ◽  
Elderly Patients ◽  
High Intensity ◽  
The Elderly ◽  
Who Grade ◽  
Follow Up Study ◽  
Intracranial Meningiomas ◽  
Antiplatelet Medication

Abstract BACKGROUND In Japan in which life expectancy exceeds 85 years old, there are many elderly people who have sufficient healthy life even over 75 years of age and maintain social activities. With the increase in life expectancy and widespread use of magnetic resonance imaging (MRI), it is estimated that the number of asymptomatic meningioma diagnosed in elderly patients will increase. They are often followed up for the elderly, but they often become symptomatic as the tumor grows. Considering the inherent complications of the elderly and the patient’s life expectancy, it is often difficult to decide whether to operate. Here, we report the results of surgical treatment for intracranial meningiomas in elderly patients growing during follow-up study. MATERIAL AND METHODS Between January 2010 and December 2018, we treated 322 meningioma patients, including 18 patients older than 75 years old who had grown during follow-up. We performed a retrospective analysis of the 18 patients and measured Tumor doubling time (TDT) using CT scan or MRI image. We mainly examined the relationship between TDT and WHO classification, MIB-1 index, edema and calcification, intensity on MRI T2 weighted-imaging. RESULTS 5 were male and 13 were female. There were 6 cases of skull base meningioma and 13 cases in which the tumor showed high intensity on the MRI T2 weighted-imaging. 4 cases showed intratumoral hemorrhage. 8 cases had edema. 11 cases were symptomatic meningiomas and 7 cases were asymptomatic meningiomas. There were 7 cases of WHO grade I meningioma and 11 cases of WHO grade II or III meningiomas. TDT was an average of 1.82 year (0.37–3.74). 9 patients have taken anticoagulant or antiplatelet medication. CONCLUSION In following up elderly meningioma patients, MRI should be performed at periodic intervals if the tumor showed high intensity on the MRI T2 weighted-imaging or had edema. In case of surgical treatment, we should pay attention to taking anticoagulant or antiplatelet medication, and treatment strategy is needed to avoid complications with sufficiently preoperative examination.

Cell surface changes during aging of human bladder epithelium examined by lectin probes and SEM

1990 ◽  
Vol 48 (3) ◽  
pp. 966-967
Author(s):  
J. Jacob ◽  
M.F.M. Ismail
Keyword(s):  
The Elderly ◽  
Ultrastructural Changes ◽  
Pokeweed Mitogen ◽  
Asymmetric Structure ◽  
Luminal Surface ◽  
Bladder Epithelium ◽  
Aldehyde Groups ◽  
Cell Surface Changes ◽  
Phosphate Buffered Saline ◽  
Surface Changes

Ultrastructural changes have been shown to occur in the urinary bladder epithelium (urothelium) during the life span of humans. With increasing age, the luminal surface becomes more flexible and develops simple microvilli-like processes. Furthermore, the specialised asymmetric structure of the luminal plasma membrane is relatively more prominent in the young than in the elderly. The nature of the changes at the luminal surface is now explored by lectin-mediated adsorption visualised by scanning electron microscopy (SEM).Samples of young adult (21-31 y old) and elderly (58-82 y old) urothelia were fixed in buffered 2% glutaraldehyde for 10 m and washed with phosphate buffered saline (PBS) containing Ca++ and Mg++ at room temperature. They were incubated overnight at 4°C in 0.1 M ammonium chloride in PBS to block any remaining aldehyde groups. The samples were then allowed to stand in PBS at 37°C for 2 h before incubation at 37°C for 30 m with lectins. The lectins used were concanavalin A (Con A), wheat germ agglutinin (WGA), phytohaemagglutinin (PHA) and pokeweed mitogen (PWM) at a concentration of 500 mg/ml in PBS at pH 7.A.

The effect of dental geriatric curricula on attitudes toward the elderly

1988 ◽  
Vol 52 (9) ◽  
pp. 516-518 ◽  
Author(s):  
J Mann ◽  
TJ Bomberg ◽  
JM Holtzman ◽  
DB Berkey
Keyword(s):  
The Elderly
Sign in / Sign up

Export Citation Format

Share Document