Gastric mucosal PGE2 levels in gastric nonulcer and ulcer patients with chronic renal failure or without renal diseases and in healthy subjects

1990 ◽  
Vol 35 (12) ◽  
pp. 1488-1493 ◽  
Author(s):  
H. Weiler ◽  
Ch. Weiler ◽  
W. Gerok
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Healthy Subjects ◽  
Renal Diseases

Disturbed lipoprotein composition in non-dialyzed, hemodialysis, continuous ambulatory peritoneal dialysis and post-transplant patients with chronic renal failure

2006 ◽  
Vol 44 (1) ◽  
Author(s):  
Elżbieta Kimak ◽  
Andrzej Książek ◽  
Janusz Solski
Keyword(s):  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Chronic Renal Failure ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Healthy Subjects ◽  
Linear Regression Analysis ◽  
Multivariate Linear Regression Analysis ◽  
Post Transplant ◽  
Transplant Patients ◽  
Lipoprotein Composition

AbstractStudies were carried out in 183 non-dialyzed, 123 hemodialysis, 81 continuous ambulatory peritoneal dialysis and 35 post-transplant patients and in 103 healthy subjects as a reference group. Lipids and apolipoprotein (apo)AI and apoB were determined using Roche kits. An anti-apoB antibody was used to separate apoB-containing apoCIII and apoE-triglyceride-rich lipoprotein (TRL) in the non-high-density lipoprotein (non-HDL) fraction from apoCIIInonB and apoEnonB in the HDL fraction in four groups of patients with chronic renal failure (CRF) and healthy subjects. Multivariate linear regression analysis was used to investigate the relationship between triglyceride (TG) or HDL-cholesterol (HDL-C) concentrations and lipoproteins. Dyslipidemia varied according to the degree of renal insufficiency, the type of dialysis and therapy regime in CRF patients. Lipoprotein disturbances were manifested by increased TG, non-HDL-C and TRL concentrations, and decreased HDL-C and apoAI concentrations, whereas post-renal transplant patients showed normalization of lipid and lipoprotein profiles, except for TG levels and total apoCIII and apoCIIInonB. The present study indicates that CRF patients have disturbed lipoprotein composition, and that hypertriglyceridemia and low HDL-C concentrations in these patients are multifactorial, being secondary to disturbed lipoproteins. The method using anti-apoB antibodies to separate apoB-containing lipoproteins in the non-HDL fraction from non-apoB-containing lipoproteins in HDL can be used in the diagnosis and treatment of patients with progression of renal failure or atherosclerosis. The variability of TG and HDL-C concentrations depends on the variability of TRL and cholesterol-rich lipoprotein concentrations, but the decreases in TG and increases in HDL-C concentrations are caused by apoAI concentration variability. These relationships, however, need to be confirmed in further studies.

Autopsy Findings in Patients Treated by Continuous Ambulatory Peritoneal Dialysis (CAPD)

1986 ◽  
Vol 6 (3) ◽  
pp. 130-135 ◽  
Author(s):  
Kostas Sombolos ◽  
Peter McNamee ◽  
Ahmed Mitwalli ◽  
Sol Rabinovich ◽  
Dimitrios G. Oreopoulos
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Causes Of Death ◽  
Coronary Artery Stenosis ◽  
Renal Diseases ◽  
Chronic Glomerulonephritis ◽  
Insulin Dependent ◽  
The Mean ◽  
Organ Changes ◽  
Acquired Cystic Disease

From October 1977 to October 1985, our pathology department did autopsies on 19 patients (14 men, five women) treated by CAPD for four to 55 (mean 29.3) months. Their mean age was 60.2 (range 28–79) years and the primary renal diseases were diabetes mellitus (eight), nephrosclerosis (five), polycystic kidneys (three), chronic glomerulonephritis (one) and chronic renal failure associated with sarcoidosis and congestive cardiomyopathy in two. During the same period, the authors selected as controls 18 autopsied patients (14 men, four women), who had not had chronic renal failure, and these were matched with the CAPD patients for age, sex, longstanding hypertension and insulin-dependent diabetes. Direct causes of death for CAPD patients were cardiovascular incidents (12) infection (5), pancreatitis (1) and lung cancer (1); in controls, the causes were cardiovascular in 11 and infection in two. Thirteen of the CAPD and 12 autopsied controls had coronary artery stenosis equal to or greater than 70%, and affecting one or more arteries. The mean weight of organs in CAPD patients and controls were similar except for kidneys and the spleen; we found the latter weighed more in those on CAPD (p = 0.002). In CAPD patients the most important organ changes were: evidence of myocardial infarction, old or acute, in nine, acquired cystic disease of the kidney in five, and thickening and adhesions of peritoneum in nine and five respectively.

Elevated temporal QT variability index in patients with chronic renal failure

2004 ◽  
Vol 107 (6) ◽  
pp. 583-588 ◽  
Author(s):  
Mats JOHANSSON ◽  
Sinsia A. GAO ◽  
Peter FRIBERG ◽  
Marita ANNERSTEDT ◽  
Göran BERGSTRÖM ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Conservative Treatment ◽  
Sudden Death ◽  
Ventricular Arrhythmia ◽  
Healthy Subjects ◽  
Increased Risk ◽  
Qt Variability Index ◽  
Qt Variability ◽  
Variability Index

Patients with CRF (chronic renal failure) are at increased risk of cardiovascular diseases, and 60% of cardiovascular mortality in CRF is attributed to sudden death. Various abnormalities in myocardial repolarization are associated with the risk of ventricular arrhythmia. The aim of this study was to evaluate an index of temporal myocardial repolarization lability, the temporal QTVI (QT variability index), in patients with CRF. ECGs were recorded in 153 patients with CRF on haemodialysis (n=67), continuous ambulatory peritoneal dialysis (n=43) or conservative treatment (n=43) during 30 min of rest. QTVI was calculated as the logarithm of the ratio between the variances of the normalized QT and RR intervals. Age-matched healthy subjects (n=39) were examined for comparison. QTVI was increased by 47% in CRF patients compared with healthy subjects (−0.82±0.56 compared with −1.54±0.27 respectively; P<0.01). QTVI did not differ among patients on dialysis or conservative treatment, whereas QTVI was elevated further in patients with diabetes compared with non-diabetic CRF patients (−0.56±0.54 compared with −0.94±0.52 respectively; P<0.01). In a multiple linear regression analysis, diabetes and a history of coronary artery disease were the only independent predictors of QTVI in the CRF population. The present study demonstrates that elevated QTVI in patients with CRF is associated with diabetes and coronary disease. The present findings are important given that repolarization instability may predispose to ventricular arrhythmia and sudden death, events that occur frequently in CRF patients.

Ion chromatographic determination of plasma oxalate in healthy subjects, in patients with chronic renal failure and in cases of hyperoxaluric syndromes

1990 ◽  
Vol 511 ◽  
pp. 223-231 ◽  
Author(s):  
Michele Petrarulo ◽  
Ornella Bianco ◽  
Martino Marangella ◽  
Sergio Pellegrino ◽  
Franco Linari ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Healthy Subjects ◽  
Chromatographic Determination

scholarly journals Kinetics, dynamics, and bioavailability of bumetanide in healthy subjects and patients with chronic renal failure

1986 ◽  
Vol 39 (6) ◽  
pp. 635-645 ◽  
Author(s):  
Henry S H Lau ◽  
Martha L Hyneck ◽  
Rosemary R Berardi ◽  
Richard D Swartz ◽  
David E Smith
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Healthy Subjects

scholarly journals HAEMODIALYSIS IN B. P. KOIRALA INSTITUTE OF HEALTH SCIENCES, DHARAN - AN INITIAL EXPERIENCE

2003 ◽  
Vol 40 (139) ◽  
pp. 134-138 ◽  
Author(s):  
Sanjib Kumar Sharma ◽  
P Kumar ◽  
A Chapagain ◽  
S Koirala
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Chronic Renal Failure ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Community Education ◽  
Health Sciences ◽  
Renal Diseases ◽  
Stage Renal Disease ◽  
End Stage

Dialysis supports life, in spite of complete cessation of renal functions. Haemodialysis(HD) service became available in B. P. Koirala Institute of Health Sciences, Dharansince September 1999. Six hundred and sixty one sessions of HD in 50 patients werecarried out in one year. End stage renal disease (ESRD), acute renal failure (ARF),acute on chronic renal failure constituted 54%, 26% and 20% of the patientsrespectively. Majority of the patients (72%) were between 15 to 50 years of age. Chronicglomerulonephritis, chronic interstitial nephritis, and diabetes nephropathy were themost common causes of ESRD. Recovery following HD was 70% in ARF,whileallpatients of acute on chronic renal failure improved following few sessions of HD.Drop out rate on maintained haemodialysis (MHD) was 52%. The increasing demandof dialysis service in this region is difficult to fulfill due to restricted facilities fordialysis, lack of renal transplantation in Nepal, and economic constraint in the part ofpatients. Primary and secondary prevention of renal diseases by community education,awareness and participation needs emphasis. Key Words: Haemodialysis, End stage renal disease, Acute renal failure,Acute on chronic renal failure.

scholarly journals Incidence of cutaneous manifestation in patients with end stage renal disease

2017 ◽  
Vol 4 (4) ◽  
pp. 989
Author(s):  
Khileshwar Singh ◽  
Amit Thakur ◽  
Kamlesh Dhruv
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Chronic Renal Failure ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Cutaneous Manifestation ◽  
Renal Diseases ◽  
Cutaneous Manifestations ◽  
Stage Renal Disease ◽  
End Stage

Background: Kidney failure as well as renal diseases is the most important health problems affecting the middle and old age population all over the world. They were supposed to be fatal till recently. The objective of this study was to study incidence of cutaneous manifestation in patients with end stage renal disease.Methods: A hospital based cross sectional study was carried out from July 2012 to June 2013 in the Department of General Medicine, Late Baliram Kashyap Memorial Government Medical College, Jagdalpur, Chhattisgarh, India. It was possible to study a total of 50 cases of cutaneous manifestations that are already known cases of end stage renal disease. All patients with skin lesion were evaluated by history, clinical examination (systemic and dermatological), biopsy and other relevant investigations procedure for skin disease during the course of current renal disease and their stay in the hospital.Results: The incidence of cutaneous manifestations among patients with acute renal failure was zero. It was 86% among patients with chronic renal failure. The most common manifestation was pruritus in 14% of cases followed by oral candidiasis in 4% of cases. Next common was scabies in 6% of cases and this was followed by herpes zoster and Tinea cruris in 4% of cases each. Folliculitis was seen in only one case. It was seen that all types of cutaneous manifestations were present only in patients with chronic renal failure, whereas patients of acute renal failure did not show any sort of cutaneous manifestations.Conclusions: Chronic renal failure was observed as the important cause of cutaneous manifestations seen in patients with end stage renal disease. No cases were seen in patients with acute renal failure. Thus, it is important that patients with acute renal failure take proper precautions to avoid cutaneous manifestations up to the extent possible.

The uremic toxin indoxyl sulfate reflects cardio-renal risk and intestinal-renal relationship

2011 ◽  
Vol 152 (43) ◽  
pp. 1724-1730 ◽  
Author(s):  
István Kiss
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Uremic Toxins ◽  
Indoxyl Sulfate ◽  
Morbidity And Mortality ◽  
Renal Diseases ◽  
Uremic Toxin ◽  
Cardiovascular Risks ◽  
Endogenous Protein ◽  
Uremic Syndrome

Uremic syndrome and condition is primarily a result of kidney failure in which uremic toxins are accumulated. More and more attention is paid to possibilities for removal of uremic toxins, which not only means dialysis, but also takes into account special dietary considerations and treatments, which aim to absorb the toxins or reduce their production. These uremic toxins, which also increase the cardiovascular risks, play a major part in morbidity and mortality of patients suffering from chronic renal failure and those receiving renal replacement therapy. One of them is a member of the indol group, the indoxyl sulfate. This toxin is difficult to remove with dialysis and is an endogenous protein-bound uremic toxin. Today we know that indoxyl sulfate is a vascular-nephrotoxic agent, which is able to enhance progression of cardiovascular and renal diseases. It is of particular importance that because of its redox potency, this toxin causes oxidative stress and antioxidant effects at the same time and, on top of that, it is formed in the intestinal system. Its serum concentration depends on the nutrition and the tubular function and, therefore, it can also signal the progression of chronic renal failure independently of glomerular filtration rate. Successful removal of indoxyl sulfate reduces the morbidity and mortality and improves survival. Therefore, it could be a possible target or area to facilitate the reduction of uremia in chronic renal failure. The use of probiotics and prebiotics with oral adsorbents may prove to be a promising opportunity to reduce indoxyl sulfate accumulation. Orv. Hetil., 2011, 152, 1724–1730.

ABNORMAL RESPONSE OF THYROTROPHIN AND GROWTH HORMONE TO THYROTROPHIN RELEASING HORMONE IN CHRONIC RENAL FAILURE

1975 ◽  
Vol 79 (4) ◽  
pp. 635-643 ◽  
Author(s):  
Koichi Hasegawa ◽  
Yoshiki Matsushita ◽  
Seima Otomo ◽  
Noboru Hamada ◽  
Yoshiki Nishizawa ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Healthy Subjects ◽  
Maximum Level ◽  
Serum Levels ◽  
Thyrotrophin Releasing Hormone ◽  
The Mean ◽  
Maximum Increment ◽  
Serum Gh ◽  
Serum Tsh

ABSTRACT Serum levels of TSH and GH were measured by radioimmunoassay after iv injection of 500 μg of TRH in 9 undialysed patients and 12 dialysed patients with chronic renal failure and in 6 healthy subjects. The basal level of the serum TSH was significantly higher in patients with chronic renal failure than that in healthy subjects. In healthy subjects, serum TSH rose to a maximum level 30 min after TRH injection, while in patients with chronic renal failure, serum TSH rose to a maximum level 60 min after TRH injection. The mean maximum increment of serum TSH in healthy subjects was significantly higher than that in patients with chronic renal failure. Although TSH levels rapidly decreased after initial rise at 30 min after TRH administration in healthy subjects, these did not show significant changes at 60 and 120 min compared with values at 30 min after TRH administration in both dialysed and undialysed patients. The basal level of serum GH was significantly higher in dialysed patients with chronic renal failure than in healthy subjects. Serum GH level was much higher in dialysed patients at 30 min after TRH injection compared with that in healthy subjects. These findings may indicate that the response of the pituitary to TRH is abnormal and that the turnover of TSH and GH is decreased in patients with chronic renal failure.

scholarly journals The Serum Analysis of Dampness Syndrome in Patients with Coronary Heart Disease and Chronic Renal Failure Based on the Theory of “Same Syndromes in Different Diseases”

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Yiming Hao ◽  
Xue Yuan ◽  
Peng Qian ◽  
Guanfeng Bai ◽  
Yiqin Wang
Keyword(s):  
Coronary Heart Disease ◽  
Renal Failure ◽  
Heart Disease ◽  
Chronic Renal Failure ◽  
Healthy Subjects ◽  
Principal Component ◽  
Serum Samples ◽  
Serum Metabolites ◽  
Underlying Basis ◽  
Patient Groups

Aim. To analyze the serum metabolites in patients with coronary heart disease (CHD) showing dampness syndrome and patients with chronic renal failure (CRF) showing dampness syndrome and to seek the substance that serves as the underlying basis of dampness syndrome in “same syndromes in different diseases.” Methods. Metabolic spectrum by GC-MS was performed using serum samples from 29 patients with CHD showing dampness syndrome and 32 patients with CRF showing dampness syndrome. The principal component analysis and statistical analysis of partial least squares were performed to detect the metabolites with different levels of expression in patients with CHD and CRF. Furthermore, by comparing the VIP value and data mining in METLIN and HMDB, we identified the common metabolites in both patient groups. Results. (1) Ten differential metabolites were found in patients with CHD showing dampness syndrome when compared to healthy subjects. Meanwhile, nine differential metabolites were found in patients with CRF showing dampness syndrome when compared to healthy subjects. (2) There were 9 differential metabolites identified when the serum metabolites of the CHD patients with dampness syndrome were compared to those of CRF patients with dampness syndrome. There were 4 common metabolites found in the serums of both patient groups.

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