Mediators of inflammation in inflammatory bowel disease

1988 ◽  
Vol 33 (S3) ◽  
pp. 4S-5S ◽  
Author(s):  
Robert D. Zipser
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Mediators Of Inflammation ◽  
Inflammatory Bowel

scholarly journals Cellular and Molecular Connections between Autophagy and Inflammation

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Pierre Lapaquette ◽  
Jean Guzzo ◽  
Lionel Bretillon ◽  
Marie-Agnès Bringer
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Unique Feature ◽  
Adaptive Immune Response ◽  
Adaptive Immune ◽  
Mediators Of Inflammation ◽  
Wide Range ◽  
Inflammatory Bowel ◽  
Diabetes And Obesity ◽  
Autophagy Activity

Autophagy is an intracellular catabolic pathway essential for the recycling of proteins and larger substrates such as aggregates, apoptotic corpses, or long-lived and superfluous organelles whose accumulation could be toxic for cells. Because of its unique feature to engulf part of cytoplasm in double-membrane cup-shaped structures, which further fuses with lysosomes, autophagy is also involved in the elimination of host cell invaders and takes an active part of the innate and adaptive immune response. Its pivotal role in maintenance of the inflammatory balance makes dysfunctions of the autophagy process having important pathological consequences. Indeed, defects in autophagy are associated with a wide range of human diseases including metabolic disorders (diabetes and obesity), inflammatory bowel disease (IBD), and cancer. In this review, we will focus on interrelations that exist between inflammation and autophagy. We will discuss in particular how mediators of inflammation can regulate autophagy activity and, conversely, how autophagy shapes the inflammatory response. Impact of genetic polymorphisms in autophagy-related gene on inflammatory bowel disease will be also discussed.

scholarly journals Mediators of Inflammation in Children with Inflammatory Bowel Disease

2003 ◽  
Vol 1 (2) ◽  
pp. 65-71 ◽  
Author(s):  
M. Hatzistilianou-Sidiropoulou ◽  
S. Nousia-Arvanitakis ◽  
A. Galli-Tsinopoulou ◽  
C. Agguridaki ◽  
M. Xefteri ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cell Activation ◽  
Inflammatory Mediators ◽  
Bowel Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Parent Molecule ◽  
Mediators Of Inflammation ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) in children remains a challenging problem. Crohn disease and ulcerative colitis are characterized by an activation of intestinal mononuclear cells and T-cells within the inflammed lesions. In the present study, we determined whether circulating inflammatory mediators, such as interleukins and adhesion molecules, may represent useful markers of immune activation in vivo. Serum concentrations of IL-2, IL-6, IL-8, IL-10, sIL-2R, sICAM-1 and sVCAM-1 were measured by a quantitative enzyme-linked immunosorbent assay (ELISA) in 18 patients with IBD and 25 healthy subjects matched for age and sex (control group). According to our results, all the inflammatory mediators are significantly increased in patients with IBD as compared to the control group. Pro-inflammatory mediators (IL-6, IL-8, IL-10) are elevated in the serum of patients with active disease, suggesting that they act as naturally occuring initiators of the acute inflammatory process. Increased IL-2 and sIL-2R levels reflect T-cell activation. Increased circulating sICAM-1 and sVCAM-1 levels may reflect increased adhesiveness and signal transmission across cells, probably as a result of shedding of the parent molecule during local cellular immunoresponses in vivo. The measurement of inflammatory mediators may be a useful adjunct to the clinical assessment and to the routine laboratory testing of IBD pediatric patients.

scholarly journals Phytochemicals Targeting JAK–STAT Pathways in Inflammatory Bowel Disease: Insights from Animal Models

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2824
Author(s):  
Sun Young Moon ◽  
Kwang Dong Kim ◽  
Jiyun Yoo ◽  
Jeong-Hyung Lee ◽  
Cheol Hwangbo
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Janus Kinase ◽  
New Drugs ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Mediators Of Inflammation ◽  
Inflammatory Bowel ◽  
Stat Pathway

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that consists of Crohn’s disease (CD) and ulcerative colitis (UC). Cytokines are thought to be key mediators of inflammation-mediated pathological processes of IBD. These cytokines play a crucial role through the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signaling pathways. Several small molecules inhibiting JAK have been used in clinical trials, and one of them has been approved for IBD treatment. Many anti-inflammatory phytochemicals have been shown to have potential as new drugs for IBD treatment. This review describes the significance of the JAK–STAT pathway as a current therapeutic target for IBD and discusses the recent findings that phytochemicals can ameliorate disease symptoms by affecting the JAK–STAT pathway in vivo in IBD disease models. Thus, we suggest that phytochemicals modulating JAK–STAT pathways are potential candidates for developing new therapeutic drugs, alternative medicines, and nutraceutical agents for the treatment of IBD.

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