Absence of effect of 16,16-dimethyl prostaglandin E2 on reduction of gastric mucosal blood flow caused by indomethacin in rats

1989 ◽  
Vol 34 (9) ◽  
pp. 1369-1373 ◽  
Author(s):  
Tetsuo Arakawa ◽  
Hajime Nakamura ◽  
Shinji Chono ◽  
Hiroshi Satoh ◽  
Takashi Fukuda ◽  
...  
Keyword(s):  
Blood Flow ◽  
Prostaglandin E2 ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow

Central neurotensin affects rat gastric integrity, prostaglandin E2, and blood flow

1989 ◽  
Vol 256 (1) ◽  
pp. G226-G232 ◽  
Author(s):  
L. Zhang ◽  
P. C. Colony ◽  
J. H. Washington ◽  
J. F. Seaton ◽  
G. L. Kauffman
Keyword(s):  
Blood Flow ◽  
Gastric Mucosa ◽  
Prostaglandin E2 ◽  
Cold Water ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Protective Role ◽  
Mucosal Integrity ◽  
Microscopic Damage ◽  
Dose Dependent

The aim of this study is to define the effect(s) of centrally administered neurotensin (NT) on gastric mucosal integrity, prostaglandin E2 (PGE2) generation, and blood flow during stress induced by cold-water restraint (CWR) in rats. Intracerebroventricular (icv) NT reduced macroscopic and microscopic damage. The former effect was dose dependent and was totally blocked by indomethacin pretreatment. Gastric mucosal PGE2 increased 27 and 30% at 30 and 60 min, respectively, in nonrestrained rats given icv NT. PGE2 generation was reduced in control rats during CWR but was maintained in CWR rats treated with icv NT. Gastric mucosal blood flow (GMBF) was significantly reduced in control rats during CWR. Mucosal blood flow was maintained at nonrestraint levels in the presence of icv NT during CWR; however, this effect was abolished by parenteral indomethacin pretreatment. Similarly, intravenous 16,16-dimethyl-PGE2 (200 micrograms.kg-1.h-1) maintained GMBF of non-CWR levels as well as preventing the macroscopic damage normally associated with CWR. These data suggest a protective role for central NT on the gastric mucosa, mediated, at least in part, by PGE2 generation and gastric mucosal blood flow.

An autoradiographic study of regional distribution of gastric mucosal blood flow

1988 ◽  
Vol 254 (4) ◽  
pp. G566-G574
Author(s):  
W. J. Angerson ◽  
J. G. Geraghty ◽  
D. C. Carter
Keyword(s):  
Blood Flow ◽  
Regional Distribution ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Autoradiographic Study ◽  
Acute Injury ◽  
Antral Mucosa ◽  
Blood Flows ◽  
Greater Curvature ◽  
Mucosal Folds

Iodo[14C]antipyrine autoradiography was used to measure gastric mucosal blood flow in anesthetized rats and to study regional distribution. Blood flows of 61 +/- 8 ml.100 g-1.min-1 (means +/- SE) in corpus and 84 +/- 9 ml.100 g-1.min-1 in antral mucosa compared well with previously reported measurements by hydrogen clearance. Blood flow in the crests of corpus mucosal folds was significantly higher than in the valleys between folds, indicating that the greater susceptibility of the former areas to acute injury, documented in several studies, is not associated with a perfusion defect in the resting stomach. Corpus mucosal blood flow was also higher in the side walls of the stomach than in the greater curvature region, and in distal than in proximal locations. No systematic regional variations within antral mucosa were demonstrated.

Gastric Mucosal Blood Flow Before and After TAE

1991 ◽  
Vol 3 (4) ◽  
pp. 513-518 ◽  
Author(s):  
Tadatoshi TSUCHIGAME ◽  
Kohshiro ITOH ◽  
Masafumi HAR ◽  
Okimitsu WATANABE ◽  
Youichi OHYAMA ◽  
...  
Keyword(s):  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Before And After

Endoscopic measurements of gastric mucosal blood flow in dogs

1985 ◽  
Vol 38 (5) ◽  
pp. 416-423 ◽  
Author(s):  
Stanley W. Ashley ◽  
Zhong-Yu Yan ◽  
David I. Soybel ◽  
Laurence Y. Cheung
Keyword(s):  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow

Gastric Mucosal Blood Flow Response to Stimulation and Inhibition of Gastric Acid Secretion

1988 ◽  
Vol 95 (3) ◽  
pp. 642-650 ◽  
Author(s):  
Josep M. Pique ◽  
Felix W. Leung ◽  
Heck W. Tan ◽  
Edward Livingston ◽  
Oscar U. Scremin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Blood Flow Response ◽  
Flow Response

Effect of Irsogladine Maleate on NSAID-Induced Reduction of Gastric Mucosal Blood Flow in Anesthetized Dogs

Digestion ◽  
2009 ◽  
Vol 79 (2) ◽  
pp. 73-78 ◽  
Author(s):  
Motonori Sato ◽  
Noriaki Manabe ◽  
Jiro Hata ◽  
Manabu Ishii ◽  
Tomoari Kamada ◽  
...  
Keyword(s):  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Irsogladine Maleate ◽  
Anesthetized Dogs

scholarly journals Neural Control of Gastric Mucosal Blood Flow in the Rat

1975 ◽  
Vol 69 (4) ◽  
pp. 935-940 ◽  
Author(s):  
Paul H. Guth ◽  
Esther Smith
Keyword(s):  
Blood Flow ◽  
Neural Control ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow

scholarly journals Focal Gastric Mucosal Blood Flow in Aspirin-induced Ulceration

1987 ◽  
Vol 205 (4) ◽  
pp. 399-403 ◽  
Author(s):  
THEOPHILUS J. GANA ◽  
ROMAN HUHLEWYCH ◽  
JARLEY KOO
Keyword(s):  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow
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