Effect of Irsogladine Maleate on NSAID-Induced Reduction of Gastric Mucosal Blood Flow in Anesthetized Dogs

Digestion ◽  
2009 ◽  
Vol 79 (2) ◽  
pp. 73-78 ◽  
Author(s):  
Motonori Sato ◽  
Noriaki Manabe ◽  
Jiro Hata ◽  
Manabu Ishii ◽  
Tomoari Kamada ◽  
...  
Keyword(s):  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Irsogladine Maleate ◽  
Anesthetized Dogs

Microsphere estimates of blood flow: methodological considerations

1988 ◽  
Vol 254 (2) ◽  
pp. G275-G279
Author(s):  
C. von Ritter ◽  
R. A. Hinder ◽  
W. Womack ◽  
P. Bauerfeind ◽  
C. J. Fimmel ◽  
...  
Keyword(s):  
Blood Flow ◽  
Reference Sample ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Volume Loss ◽  
Dextran 70 ◽  
Anesthetized Dogs ◽  
Methodological Considerations ◽  
Pentobarbital Sodium Anesthesia ◽  
Reference Samples

The microsphere technique is a standard method for measuring blood flow in experimental animals. Sporadic reports have appeared outlining the limitations of this method. In this study we have systematically assessed the effect of blood withdrawals for reference sampling, microsphere numbers, and anesthesia on blood flow estimates using radioactive microspheres in dogs. Experiments were performed on 18 conscious and 12 anesthetized dogs. Four blood flow estimates were performed over 120 min using 1 X 10(6) microspheres (15 microns) each time. The effects of excessive numbers of microspheres (13 million), pentobarbital sodium anesthesia (30 mg/kg), and replacement of volume loss for reference samples with dextran 70 were assessed. In both conscious and anesthetized dogs a progressive decrease in gastric mucosal blood flow and cardiac output was observed over 120 min. This was also observed in the pancreas in conscious dogs. The major factor responsible for these changes was the volume loss due to reference sample withdrawals. Replacement of the withdrawn blood with dextran 70 led to stable blood flows to all organs. The injection of excessive numbers of microspheres did not modify hemodynamics to a greater extent than did the injection of 4 million microspheres. Anesthesia exerted no influence on blood flow other than raising coronary flow. We conclude that although blood flow to the gastric mucosa and the pancreas is sensitive to the minor hemodynamic changes associated with the microsphere technique, replacement of volume loss for reference samples ensures stable blood flow to all organs over a 120-min period.

Dopamine-1 receptor stimulation impairs intestinal oxygen utilization during critical hypoperfusion

2003 ◽  
Vol 284 (2) ◽  
pp. H668-H675 ◽  
Author(s):  
Jorge A. Guzman ◽  
Ariosto E. Rosado ◽  
James A. Kruse
Keyword(s):  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Control Group ◽  
Oxygen Utilization ◽  
Hemorrhage Control ◽  
Receptor Stimulation ◽  
Anesthetized Dogs ◽  
Group 2 ◽  
Increased Susceptibility ◽  
Group 1

Effects of a dopamine-1 (DA-1) receptor agonist on systemic and intestinal oxygen delivery (D˙o 2)-uptake relationships were studied in anesthetized dogs during sequential hemorrhage. Control ( group 1) and experimental animals ( group 2) were treated similarly except for the addition of fenoldopam (1.0 μg · kg−1 · min−1) in group 2. Both groups had comparable systemic criticalD˙o 2(D˙o 2crit), but animals in group 2 had a higher gut D˙o 2crit(1.12 ± 1.13 vs. 0.80 ± 0.09 ml · kg−1 · min−1, P < 0.05). At the mucosal level, a clear biphasic delivery-uptake relationship was not observed in group 1; thus oxygen consumption by the mucosa may be supply dependent under physiological conditions. Group 2 demonstrated higher peak mucosal blood flow and lack of supply dependency at higher mucosalD˙o 2 levels. Fenoldopam resulted in a more conspicuous biphasic relationship at the mucosa and a rightward shift of overall splanchnic D˙o 2crit despite increased splanchnic blood flow. These findings suggest that DA-1 receptor stimulation results in increased gut perfusion heterogeneity and maldistribution of perfusion, resulting in increased susceptibility to ischemia.

An autoradiographic study of regional distribution of gastric mucosal blood flow

1988 ◽  
Vol 254 (4) ◽  
pp. G566-G574
Author(s):  
W. J. Angerson ◽  
J. G. Geraghty ◽  
D. C. Carter
Keyword(s):  
Blood Flow ◽  
Regional Distribution ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Autoradiographic Study ◽  
Acute Injury ◽  
Antral Mucosa ◽  
Blood Flows ◽  
Greater Curvature ◽  
Mucosal Folds

Iodo[14C]antipyrine autoradiography was used to measure gastric mucosal blood flow in anesthetized rats and to study regional distribution. Blood flows of 61 +/- 8 ml.100 g-1.min-1 (means +/- SE) in corpus and 84 +/- 9 ml.100 g-1.min-1 in antral mucosa compared well with previously reported measurements by hydrogen clearance. Blood flow in the crests of corpus mucosal folds was significantly higher than in the valleys between folds, indicating that the greater susceptibility of the former areas to acute injury, documented in several studies, is not associated with a perfusion defect in the resting stomach. Corpus mucosal blood flow was also higher in the side walls of the stomach than in the greater curvature region, and in distal than in proximal locations. No systematic regional variations within antral mucosa were demonstrated.

Gastric Mucosal Blood Flow Before and After TAE

1991 ◽  
Vol 3 (4) ◽  
pp. 513-518 ◽  
Author(s):  
Tadatoshi TSUCHIGAME ◽  
Kohshiro ITOH ◽  
Masafumi HAR ◽  
Okimitsu WATANABE ◽  
Youichi OHYAMA ◽  
...  
Keyword(s):  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Before And After

Endoscopic measurements of gastric mucosal blood flow in dogs

1985 ◽  
Vol 38 (5) ◽  
pp. 416-423 ◽  
Author(s):  
Stanley W. Ashley ◽  
Zhong-Yu Yan ◽  
David I. Soybel ◽  
Laurence Y. Cheung
Keyword(s):  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow

Gastric Mucosal Blood Flow Response to Stimulation and Inhibition of Gastric Acid Secretion

1988 ◽  
Vol 95 (3) ◽  
pp. 642-650 ◽  
Author(s):  
Josep M. Pique ◽  
Felix W. Leung ◽  
Heck W. Tan ◽  
Edward Livingston ◽  
Oscar U. Scremin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Blood Flow Response ◽  
Flow Response

scholarly journals Neural Control of Gastric Mucosal Blood Flow in the Rat

1975 ◽  
Vol 69 (4) ◽  
pp. 935-940 ◽  
Author(s):  
Paul H. Guth ◽  
Esther Smith
Keyword(s):  
Blood Flow ◽  
Neural Control ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow

scholarly journals Focal Gastric Mucosal Blood Flow in Aspirin-induced Ulceration

1987 ◽  
Vol 205 (4) ◽  
pp. 399-403 ◽  
Author(s):  
THEOPHILUS J. GANA ◽  
ROMAN HUHLEWYCH ◽  
JARLEY KOO
Keyword(s):  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow
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