Determination of tranexamic acid (AMCA) and fibrin/fibrinogen degradation products in cerebrospinal fluid after aneurysmal subarachnoid haemorrhage

1981 ◽  
Vol 58 (1-2) ◽  
pp. 1-13 ◽  
Author(s):  
H. Fodstad ◽  
A. Pilbrant ◽  
M. Schannonǵ ◽  
S. Strömberǵ
Keyword(s):  
Cerebrospinal Fluid ◽  
Subarachnoid Haemorrhage ◽  
Tranexamic Acid ◽  
Degradation Products ◽  
Aneurysmal Subarachnoid Haemorrhage ◽  
Fibrinogen Degradation Products

Source of fibrin/fibrinogen degradation products in the CSF after subarachnoid hemorrhage

1985 ◽  
Vol 63 (4) ◽  
pp. 573-577 ◽  
Author(s):  
Marinus Vermeulen ◽  
Huub H. D. M. van Vliet ◽  
Kenneth W. Lindsay ◽  
Albert Hijdra ◽  
Jan van Gijn
Keyword(s):  
Cerebrospinal Fluid ◽  
Subarachnoid Hemorrhage ◽  
Tranexamic Acid ◽  
Degradation Products ◽  
Control Group ◽  
Content Type ◽  
Fibrinogen Degradation Products ◽  
Level Of Consciousness ◽  
Local Fibrinolysis ◽  
Fine Print

✓ In 48 patients with a subarachnoid hemorrhage, levels of fibrin/fibrinogen degradation products (FDP's), total protein, and plasminogen were measured in the cerebrospinal fluid (CSF) between Days 9 and 15 after the bleed. Of these 48 patients, 22 received tranexamic acid. Despite a significant reduction in the incidence of rebleeding in patients taking tranexamic acid, no difference in FDP levels was found between patients receiving tranexamic acid and a control group of patients who were not; nor was any relationship evident between FDP levels and rebleeding. In patients with detectable levels of FDP's, CSF protein and plasminogen values were also increased, and FDP's were found more frequently in the CSF of patients with an impaired level of consciousness or with a neurological deficit. These findings suggest that in the 2nd week after subarachnoid hemorrhage, the presence of FDP's in the CSF reflects a damaged blood-CSF barrier rather than ongoing local fibrinolysis in the subarachnoid space. A finding of FDP's in the CSF is, therefore, an unreliable monitor of antifibrinolytic treatment in subarachnoid hemorrhage and cannot be used for selecting patients at high risk of rebleeding.

Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: a pattern-recognition1H NMR study

2005 ◽  
Vol 18 (1) ◽  
pp. 24-33 ◽  
Author(s):  
Victoria G. Dunne ◽  
Shermina Bhattachayya ◽  
Michael Besser ◽  
Caroline Rae ◽  
Julian L. Griffin
Keyword(s):  
Cerebrospinal Fluid ◽  
Clinical Outcome ◽  
Subarachnoid Haemorrhage ◽  
Aneurysmal Subarachnoid Haemorrhage ◽  
Nmr Study

HPLC method for measurement of purine nucleotide degradation products in cerebrospinal fluid

1996 ◽  
Vol 42 (5) ◽  
pp. 756-760 ◽  
Author(s):  
L Kuracka ◽  
T Kalnovicová ◽  
B Líska ◽  
P Turcáni
Keyword(s):  
Cerebrospinal Fluid ◽  
Uric Acid ◽  
Neurological Disorders ◽  
Limit Of Detection ◽  
Degradation Products ◽  
Potassium Phosphate ◽  
Hplc Method ◽  
Potassium Phosphate Buffer ◽  
Nucleotide Degradation

Abstract We describe a convenient method for the separation and quantification of xanthine, hypoxanthine, and uric acid in 20 microL of cerebrospinal fluid (CSF) with use of HPLC and ultraviolet detection. The analysis is performed on a Sepharon SGX C18 column and the elution system consists of potassium phosphate buffer, pH 5.1, with 20 mL/L methanol. The lower limit of detection was 4 pmol for hypoxanthine and xanthine and 6 pmol for uric acid. Analytical recoveries of purine metabolites ranged from 98.6% to 102.9%. The intra- and interassay CVs were <3%. The applicability of the method is illustrated with the determination of micromolar concentrations of xanthine, hypoxanthine, and uric acid in CSF samples obtained from 113 patients with various neurological disorders.

Superoxide dismutase activity in cisternal cerebrospinal fluid after aneurysmal subarachnoid haemorrhage

1997 ◽  
Vol 139 (11) ◽  
pp. 1033-1037 ◽  
Author(s):  
P. Gaetani ◽  
C. Cafe ◽  
R. Rodriguez y Baena ◽  
F. Tancioni ◽  
C. Torri ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Superoxide Dismutase ◽  
Subarachnoid Haemorrhage ◽  
Superoxide Dismutase Activity ◽  
Aneurysmal Subarachnoid Haemorrhage

Determination of Urinary Fibrin/Fibrinogen Degradation Products by Radioimmunoassay

1976 ◽  
Vol 36 (5) ◽  
pp. 453-459 ◽  
Author(s):  
M. Ekberg ◽  
Ulla Hedner ◽  
I. Larsson ◽  
Inga Marie Nilsson ◽  
B. Nosslin
Keyword(s):  
Degradation Products ◽  
Fibrinogen Degradation Products

scholarly journals Correction: Soluble Toll-Like Receptors 2 and 4 in Cerebrospinal Fluid of Patients with Acute Hydrocephalus following Aneurysmal Subarachnoid Haemorrhage

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0157853
Author(s):  
Bartosz Sokół ◽  
Norbert Wąsik ◽  
Roman Jankowski ◽  
Marcin Hołysz ◽  
Barbara Więckowska ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Subarachnoid Haemorrhage ◽  
Aneurysmal Subarachnoid Haemorrhage ◽  
Toll Like Receptors ◽  
Acute Hydrocephalus
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