Antineuraminidase antibody response to vaccination of chickens with intact virus and different subunit preparations of the influenza virus strains A/Sing/1/57 (H2N2), A/Hong Kong/1/68 (H3N2) and A/Port Chalmers/1/73 (H3N2)

1980 ◽  
Vol 64 (3) ◽  
pp. 235-246 ◽  
Author(s):  
J. Drescher ◽  
U. Desselberger
Keyword(s):  
Influenza Virus ◽  
Hong Kong ◽  
Antibody Response ◽  
Intact Virus ◽  
Virus Strains

scholarly journals Haemagglutination-inhibiting (HI) antibodies against four prototype strains of influenza A virus in different age groups

1979 ◽  
Vol 82 (2) ◽  
pp. 225-230 ◽  
Author(s):  
A. L. Terzin ◽  
S. Djurišić ◽  
B. Vuković ◽  
V. Vujkov
Keyword(s):  
Influenza Virus ◽  
Hong Kong ◽  
New Jersey ◽  
Antibody Response ◽  
Influenza A ◽  
Geometric Mean ◽  
Age Groups ◽  
The Other ◽  
Younger Age ◽  
Lower Antibody Response

SUMMARYSera of 197 apparently well persons were tested for residual haemagglutination-inhibiting antibodies against live Hong Kong/68, A/FM/47 and A/PR/34 strains. Sera of 62 well persons, regularly exposed to contacts with swine, were tested against an inactivated A/New Jersey/76 antigen.Those born some time before and during a certain influenza era showed a significantly greater proportion of homologous residual titres against the subtype prevailing in that influenza era, than those born after the termination of the same era.In each of the seven age groups tested both the percentage of positives and the geometric mean titres were usually highest against the Hong Kong strain (representing the most recent era); the next highest were those against the FM1 strain and the lowest were those against the PR8 strain (representing the most distant of these three influenza eras).The serological involvement of donors exposed to regular contacts with swine was relatively stronger against the New Jersey antigen than the response of other serum donors shown against the other three, more recent, prototypes of influenza virus A. The oldest age groups showed significantly lower antibody response against the PR8, FM1 and Hong Kong strains (but not against the New Jersey antigen) than the next one or two of the younger age groups.

Caractères biologiques de souches du virus de l'influenza adaptées à 29 °C et à 41 °C

1968 ◽  
Vol 14 (8) ◽  
pp. 867-874 ◽  
Author(s):  
A. Boudreault ◽  
G. Lussier ◽  
V. Pavilanis
Keyword(s):  
Influenza Virus ◽  
Chick Embryo ◽  
Antibody Response ◽  
Marked Reduction ◽  
Pathological Response ◽  
Mouse Lung ◽  
Live Virus ◽  
Live Virus Vaccine ◽  
Significant Difference ◽  
Virus Strains

Two mouse-adapted influenza virus strains were adapted to growth at 29 °C by a gradual lowering of the temperature of incubation in embryonated eggs. The growth of these two cold variants was completely inhibited at 41 °C. The cold and hot variants showed no significant difference in rise in the infectious titer in the mouse lung but a marked reduction in mortality and pathological response was observed with the cold variants, while good antibody response was stimulated in both cases. The cold variants were better interferon inducers in chick embryo. However, neither cold nor hot variants induced more than detectable amounts of interferon in blood, spleen, or lungs of infected mice. These cold variants possess many characteristics suitable for an effective live virus vaccine.

scholarly journals Characterization of the Influenza A Virus Gene Pool in Avian Species in Southern China: Was H6N1 a Derivative or a Precursor of H5N1?

2000 ◽  
Vol 74 (14) ◽  
pp. 6309-6315 ◽  
Author(s):  
Erich Hoffmann ◽  
Juergen Stech ◽  
Irina Leneva ◽  
Scott Krauss ◽  
Christoph Scholtissek ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Hong Kong ◽  
Amino Acid ◽  
Influenza A ◽  
Southern China ◽  
Bird Species ◽  
Limited Information ◽  
H5n1 Influenza ◽  
Nucleotide Homology ◽  
Virus Strains

ABSTRACT In 1997, an H5N1 influenza virus outbreak occurred in chickens in Hong Kong, and the virus was transmitted directly to humans. Because there is limited information about the avian influenza virus reservoir in that region, we genetically characterized virus strains isolated in Hong Kong during the 1997 outbreak. We sequenced the gene segments of a heterogeneous group of viruses of seven different serotypes (H3N8, H4N8, H6N1, H6N9, H11N1, H11N9, and H11N8) isolated from various bird species. The phylogenetic relationships divided these viruses into several subgroups. An H6N1 virus isolated from teal (A/teal/Hong Kong/W312/97 [H6N1]) showed very high (>98%) nucleotide homology to the human influenza virus A/Hong Kong/156/97 (H5N1) in the six internal genes. The N1 neuraminidase sequence showed 97% nucleotide homology to that of the human H5N1 virus, and the N1 protein of both viruses had the same 19-amino-acid deletion in the stalk region. The deduced hemagglutinin amino acid sequence of the H6N1 virus was most similar to that of A/shearwater/Australia/1/72 (H6N5). The H6N1 virus is the first known isolate with seven H5N1-like segments and may have been the donor of the neuraminidase and the internal genes of the H5N1 viruses. The high homology between the internal genes of H9N2, H6N1, and the H5N1 isolates indicates that these subtypes are able to exchange their internal genes and are therefore a potential source of new pathogenic influenza virus strains. Our analysis suggests that surveillance for influenza A viruses should be conducted for wild aquatic birds as well as for poultry, pigs, and humans and that H6 isolates should be further characterized.

scholarly journals ANTIVIRAL EFFECT OF «KAGOCEL» SUBSTANCE IN VITRO ON INFLUENZA VIRUSES H1N1, H1N1PDM09 AND H3N2

2019 ◽  
Vol 64 (3) ◽  
pp. 125-131 ◽  
Author(s):  
I. T. Fediakina ◽  
M. V. Konopleva ◽  
E. S. Proshina ◽  
E. V. Linnik ◽  
N. I. Nikitina
Keyword(s):  
Influenza Virus ◽  
Puerto Rico ◽  
Hong Kong ◽  
Mdck Cells ◽  
Influenza Viruses ◽  
Viral Antigens ◽  
Antiviral Efficacy ◽  
2009 H1n1 ◽  
Virus Strains

Introduction. Active circulation of pandemic influenza and new variants of influenza H3N2 strains requires monitoring of antiviral efficacy of drugs permitted for influenza therapy in the Russian Federation. Purpose. Assessment of antiviral efficacy of «Kagocel» substance against influenza viruses H1N1, H1N1pdm09 and H3N2 in vitro. Material and methods. Cytotoxic effect of «Kagocel» substance on MDCK cells had been determined by stained with MTS. Antiviral efficacy of «Kagocel» substance against influenza infection has been studied in vitro in the culture of MDCK cells infected with influenza virus strains: A/Puerto Rico/8/34 (H1N1), А/California/7/2009 (H1N1)pdm09, А/Hong Kong/1/68 (H3N2) and А/Hong Kong/4801/2014 (H3N2). The antiviral activity of «Kagocel» substance was tested by its effect on the infectious titer of the influenza viruses and on its impact on the expression level of viral antigens in the enzyme immunoassay test system. Results. «Kagocel» substance had low toxicity for MDCK cells. «Kagocel» inhibited the infection titer of influenza virus strains A/Puerto Rico/8/34 (H1N1), А/California/7/2009 (H1N1)pdm09, А/Hong Kong/1/68 (H3N2) and А/ Hong Kong /4801/2014 (H3N2) in the MDCK cell culture with equal efficacy. Study of the impact of «Kagocel» substance on the expression level of viral antigens by ELISA also revealed its antiviral efficacy for all tested strains. Dose dependence was observed from concentration of substance and from infective dose of virus. Discussion. Effective suppression of the reproduction of influenza virus strains A(H1N1), A(Н1N1)pdm09 and A(H3N2) in the different sublines of MDCK cells with «Kagocel» was shown by the different methods. These results give the possibility to suggest that along with the ability to induce interferons, «Kagocel» can impact on the reproduction of influenza virus, but the further research is needed. Conclusion. «Kagocel» substance effectively inhibits the reproduction of influenza virus strains A(H1N1), A(Н1N1)pdm09 and A(H3N2) in vitro. At the same time, the selectivity index is quite high.

scholarly journals Changes in the antibody status of a population following epidemic infection by influenza virus A2/Hong Kong/1/68

1970 ◽  
Vol 68 (3) ◽  
pp. 497-504 ◽  
Author(s):  
S. J. Machin ◽  
C. W. Potter ◽  
J. S. Oxford
Keyword(s):  
Influenza Virus ◽  
Hong Kong ◽  
Influenza Viruses ◽  
Influenza Virus A ◽  
Anti Body ◽  
Antibody Tests ◽  
Virus Strains

SUMMARYThe haemagglutinin of influenza virus A 2/Hong Kong/1/68 was shown to be markedly different from that of previously isolated A 2 virus strains. No haemagglutination-inhibiting (HI) antibody to A 2/Hong Kong/1/68 virus was detected in serum specimens collected in 1966 from persons aged 60 years or less. In contrast, HI antibody tests with 270 sera collected in 1968 indicated that 9·6% had demonstrable HI antibody at low titres, and 35·2% of 454 postepidemic (1969) sera had demonstrable HI antibody at relatively high titres. Most sera from persons aged 80 years and more collected in 1968 and 1969 had demonstrable HI anti-body to influenza virus A 2/Hong Kong/1/68. No HI antibody to the Hong Kong virus was detected in pre-epidemic sera from children aged 6 months to 3 years, whereas 32 % of postepidemic sera had HI antibody. The acquisition of HI antibody to A 2/Hong Kong/1/68 was not accompanied by an increase hi the incidence or titres of HI antibody to heterotypic A 2 influenza viruses. For sera from children aged 4–11 years, an increase of HI titre to heterotypic A 2 influenza was found.

scholarly journals The follow-up study of swine and Hong Kong influenza virus infection among Japanese hogs.

1982 ◽  
Vol 136 (4) ◽  
pp. 353-358 ◽  
Author(s):  
JIRO ARIKAWA ◽  
NOBUHISA YAMANE ◽  
KIYOSHI TOTSUKAWA ◽  
NAKAO ISHIDA
Keyword(s):  
Influenza Virus ◽  
Hong Kong ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
Follow Up Study
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