Differential susceptibility and resistance of immunocompetent and immunodeficient mice to fatal Hantaan virus infection

1985 ◽  
Vol 86 (1-2) ◽  
pp. 109-120 ◽  
Author(s):  
T. Nakamura ◽  
R. Yanagihara ◽  
C. J. Gibbs ◽  
H. L. Amyx ◽  
D. C. Gajdusek
Keyword(s):  
Virus Infection ◽  
Differential Susceptibility ◽  
Hantaan Virus ◽  
Immunodeficient Mice ◽  
Susceptibility And Resistance

scholarly journals A Case of Graves' Disease Combined with Hantaan Virus Infection

2009 ◽  
Vol 24 (1) ◽  
pp. 158 ◽  
Author(s):  
Heung Yong Jin ◽  
Seon Mee Kang ◽  
So Young Kim ◽  
Ji Hyun Park ◽  
Hong Sun Baek ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hantaan Virus ◽  
Graves Disease

Acute Appendicitis Associated with Hantaan Virus Infection

2021 ◽  
Author(s):  
Sung-Chul Lim ◽  
Young Min Lee ◽  
Choon-Mee Kim ◽  
Na Ra Yun ◽  
Dong-Min Kim
Keyword(s):  
Virus Infection ◽  
Peripheral Nerve ◽  
Hemorrhagic Fever ◽  
Hantaan Virus ◽  
Nerve Bundle ◽  
Rt Pcr ◽  
Antibody Assay ◽  
Immunofluorescent Antibody ◽  
Virus Antigens ◽  
Indirect Immunofluorescent

Hantaviruses are Bunyaviridae viruses that cause hemorrhagic fever with renal syndrome (HFRS). Appendicitis caused by Hantaan virus has not been reported previously. An 81-year-old man who underwent laparoscopic appendectomy for suspected appendicitis based on abdominal pain, fever, hypotension, and computed tomography findings. Based on a suspicion of hemorrhagic fever with renal syndrome, the patient’s plasma was simultaneously analyzed using an indirect immunofluorescent antibody assay and nested reverse transcription–polymerase chain reaction (RT-PCR). The appendix tissue was also analyzed using nested RT-PCR and immunohistochemical (IHC) staining to identify the presence of Hantaan virus. Nested RT-PCR detected the presence of Hantaan virus, and indirect immunofluorescent antibody assay results revealed the presence of elevated antibody levels. Furthermore, IHC staining of the appendix tissue confirmed Hantaan virus antigens in the peripheral nerve bundle. Based on these findings, we confirmed the nerve tropism of the Hantaan virus. Hantaan virus in plasma and appendix tissue samples was confirmed using PCR and phylogenetic tree analysis. Moreover, we detected hypertrophy of the submucosa and periappendiceal adipose tissue nerve bundle along with Hantaan virus antigens in peripheral nerve bundles using IHC staining. Hence, we report that Hantaan virus infection may be accompanied by appendicitis.

scholarly journals Constitutive Activation of U937 Promonocytic Cell Clones Selected for Their Resistance to Parvovirus H-1 Infection

Blood ◽  
1997 ◽  
Vol 89 (5) ◽  
pp. 1642-1653 ◽  
Author(s):  
José Antonio López-Guerrero ◽  
Béatrice Rayet ◽  
Marcel Tuynder ◽  
Jean Rommelaere ◽  
Christiane Dinsart
Keyword(s):  
Virus Infection ◽  
Active Oxygen Species ◽  
Membrane Surface ◽  
Nonspecific Esterase ◽  
Monocytic Differentiation ◽  
Immunodeficient Mice ◽  
Myc Oncogene ◽  
Cell Clones ◽  
A Cell ◽  
Constitutive Production

Abstract The human promonocytic cell line U937 is highly sensitive to the lytic effect of the autonomous parvovirus H-1. Rare cell variants that resisted H-1 virus infection could be isolated, of which four (RU1, RU2, RU3, and RU4) were further characterized. In contrast to parental cells, the RU clones sustained an abortive H-1 virus infection. Three of the clones showed a significant decrease in the accumulation levels of the c-Myc oncoprotein and in their capacity for forming tumors in immunodeficient mice. Surprisingly, all RU clones resisted the suppressing effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on c-myc oncogene expression and cell proliferation. In contrast, RU clones exhibited the TPA-induced changes in membrane surface antigens and nonspecific esterase activities that are characteristic of monocytic differentiation. Studies of the activation steady-state of RU cells demonstrated the constitutive production of significant amounts of nitric oxide (NO) and superoxide anion (O−2⋅ ). Inhibitors of NO and O−2⋅ . production sensitized all RU cells to the killing effect of parvovirus H-1 and increased the production of infectious viral particles. These data argue for the participation of active oxygen species in macrophage defence mechanisms against parvovirus infection. Moreover, the use of parvovirus H-1 as a selective agent in a cell-colony formation assay allowed us to show that expression of defined markers of monocytic differentiation can be uncoupled from suppression of proliferation.

Epidemiological Survey of Hantaan Virus Infection of Wild Rodents Trapped in Jeollanam-do, 2003~2004

2006 ◽  
Vol 36 (3) ◽  
pp. 205 ◽  
Author(s):  
Hyeon-Je Song ◽  
Dae-Yeon Lee ◽  
Choong-Mo Kim ◽  
Young-Hack Shin
Keyword(s):  
Virus Infection ◽  
Epidemiological Survey ◽  
Hantaan Virus ◽  
Wild Rodents

scholarly journals Serologic Diagnosis of Hantaan Virus Infection Based on a Peptide Antigen

2002 ◽  
Vol 48 (4) ◽  
pp. 645-647 ◽  
Author(s):  
Zheng Li ◽  
Xuefan Bai ◽  
Huijie Bian
Keyword(s):  
Virus Infection ◽  
Hantaan Virus ◽  
Peptide Antigen ◽  
Serologic Diagnosis
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