Gastrointestinal bleeding due to chronic portal vein thrombosis in ulcerative colitis

1979 ◽  
Vol 24 (3) ◽  
pp. 232-235 ◽  
Author(s):  
Jean-Pierre Capron ◽  
Alexandre Remond ◽  
Didier Lebrec ◽  
Jacques Delamarre ◽  
Jean-Louis Dupas ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Gastrointestinal Bleeding ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Vein Thrombosis

scholarly journals Refractory bleeding from ectopic varices stopped by percutaneous transhepatic portal vein recanalization and stenting

2016 ◽  
Vol 3 (3) ◽  
pp. 52
Author(s):  
Guido Poggi ◽  
Cesare Massa Saluzzo ◽  
Benedetta Montagna ◽  
Chiara Picchi ◽  
Francesco Salerno
Keyword(s):  
Gastrointestinal Bleeding ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Stent Placement ◽  
Severe Bleeding ◽  
Jejunal Varices ◽  
Vein Thrombosis ◽  
Ectopic Varices

Ectopic varices is an uncommon cause of gastrointestinal bleeding. We reported a case of severe bleeding due to jejunal varices which arose as a complication of extrahepatic portal vein thrombosis. The patient was successfully treated by portal vein recanalization and  percutaneous transhepatic stent placement.

scholarly journals Non Cirrhotic Portal Vein Thrombosis: Diagnostic and Therapeutic Challenge

2021 ◽  
Vol 22 (1) ◽  
pp. 79-83
Author(s):  
Syifa Mustika ◽  
Pratista Adi Krisna
Keyword(s):  
Gastrointestinal Bleeding ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Upper Gastrointestinal Bleeding ◽  
Recurrent Thrombosis ◽  
Common Cause ◽  
Vein Thrombosis ◽  
Physical Laboratory ◽  
Prevention And Treatment ◽  
Upper Gastrointestinal

Portal vein thrombosis (PVT), the second most common cause of portal hypertension, can be found in cirrhosis and non-cirrhosis patients. Various factors can cause non-cirrhosis PVT, such as biliary infection. Upper gastrointestinal bleeding without sign of liver failure, must be considered as non-cirrhosis PVT manifestation. Combining physical, laboratory, endoscopic and radiological examination is needed to establish the diagnosis of PVT. The principle of PVT management consists of 3 keypoints. They are prevention and treatment of gastrointestinal bleeding, prevention of recurrent thrombosis and portal cholangiopathy therapy. Many aspect should be considered regarding the administration of anticoagulants in PVT patients, especially chronic PVT with cavernomas.

scholarly journals Extrahepatic Portal Vein Thrombosis, an Important Cause of Portal Hypertension in Children

2021 ◽  
Vol 10 (12) ◽  
pp. 2703
Author(s):  
Alina Grama ◽  
Alexandru Pîrvan ◽  
Claudia Sîrbe ◽  
Lucia Burac ◽  
Horia Ştefănescu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Portal Hypertension ◽  
Gastrointestinal Bleeding ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Bacterial Infections ◽  
Umbilical Vein ◽  
Clinical Manifestations ◽  
Vein Thrombosis ◽  
Vein Catheterization

One of the most important causes of portal hypertension among children is extrahepatic portal vein thrombosis (EHPVT). The most common risk factors for EHPVT are neonatal umbilical vein catheterization, transfusions, bacterial infections, dehydration, and thrombophilia. Our study aimed to describe the clinical manifestations, treatment, evolution, and risk factors of children with EHPVT. Methods: We analyzed retrospectively all children admitted and followed in our hospital with EHPVT between January 2011–December 2020. The diagnosis was made by ultrasound or contrast magnetic resonance imaging. We evaluated the onset symptoms, complications, therapeutic methods, and risk factors. Results: A total of 63 children, mean age 5.14 ± 4.90 (33 boys, 52.38%), were evaluated for EHPVT during the study period. The first symptoms were upper gastrointestinal bleeding (31 children, 49.21%) and splenomegaly (22 children, 34.92%). Thrombocytopenia was present in 44 children (69.84%). The most frequent risk factors were umbilical vein catheterization (46 children, 73.02%) and bacterial infections during the neonatal period (30 children, 47.62%). Protein C, protein S, antithrombin III levels were decreased in 44 of the 48 patients tested. In 42 of these cases, mutations for thrombophilia were tested, and 37 were positive. Upper digestive endoscopy was performed in all cases, revealing esophageal varices in 56 children (88.89%). All children with gastrointestinal bleeding received an octreotide infusion. In 26 children (41.27%), variceal ligation was performed, and in 5 children (7.94%), sclerotherapy. Porto-systemic shunt was performed in 11 children (17.46%), and Meso-Rex shunt was done in 4 children (6.35%). The evolution was favorable in 62 cases (98.41%). Only one child died secondary to severe sepsis. Conclusions: EHPVT is frequently diagnosed in the last period in our region due to the increased use of umbilical vein catheterization. Furthermore, genetic predisposition, neonatal bacterial infections, and prematurity certainly play an important role in this condition. A proactive ultrasound assessment of children with risk factors for EHPVT should be encouraged for early diagnosis and treatment.

Anticoagulant therapy in patients with non-cirrhotic portal vein thrombosis: effect on new thrombotic events and gastrointestinal bleeding

2013 ◽  
Vol 11 (3) ◽  
pp. 452-459 ◽  
Author(s):  
M. C. W. Spaander ◽  
J. Hoekstra ◽  
B. E. Hansen ◽  
H. R. Van Buuren ◽  
F. W. G. Leebeek ◽  
...  
Keyword(s):  
Gastrointestinal Bleeding ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Anticoagulant Therapy ◽  
Vein Thrombosis

scholarly journals Portal vein thrombosis in children and adolescents: 20 years experience of a pediatric hepatology reference center

2012 ◽  
Vol 49 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Priscila Menezes Ferri ◽  
Alexandre Rodrigues Ferreira ◽  
Eleonora Druve Tavares Fagundes ◽  
Shinfay Maximilian Liu ◽  
Mariza Leitão Valadares Roquete ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Gastrointestinal Bleeding ◽  
Portal Vein ◽  
Children And Adolescents ◽  
Portal Vein Thrombosis ◽  
Upper Gastrointestinal Bleeding ◽  
First Episode ◽  
High Morbidity ◽  
Vein Thrombosis ◽  
Upper Gastrointestinal

CONTEXT: Portal vein thrombosis refers to a total or partial obstruction of the blood flow in this vein due to a thrombus formation. It is an important cause of portal hypertension in the pediatric age group with high morbidity rates due to its main complication - the upper gastrointestinal bleeding. OBJECTIVE: To describe a group of patients with portal vein thrombosis without associated hepatic disease of the Pediatric Hepatology Clinic of the Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil with emphasis on diagnosis, presentation form and clinical complications, and the treatment of portal hypertension. METHODS: This is a descriptive study of a series of children and adolescents cases assisted from January 1990 to December 2010. The portal vein thrombosis diagnosis was established by ultrasound. RESULTS: Of the 55 studied patients, 30 (54.5%) were male. In 29 patients (52.7%), none of the risk factors for portal vein thrombosis was observed. The predominant form of presentation was the upper gastrointestinal bleeding (52.7%). In 20 patients (36.4%), the initial manifestation was splenomegaly. During the whole following period of the study, 39 patients (70.9%) showed at least one episode of upper gastrointestinal bleeding. The mean age of patients in the first episode was 4.6 ± 3.4 years old. The endoscopic procedure carried out in the urgency or electively for search of esophageal varices showed its presence in 84.9% of the evaluated patients. The prophylactic endoscopic treatment was performed with endoscopic band ligation of varices in 31.3% of patients. Only one died due to refractory bleeding. CONCLUSIONS: The portal vein thrombosis is one of the most important causes of upper gastrointestinal bleeding in children. In all non febrile children with splenomegaly and/or hematemesis and without hepatomegaly and with normal hepatic function tests, it should be suspect of portal vein thrombosis. Thus, an appropriate diagnostic and treatment approach is desirable in an attempt to reduce morbidity and mortality.

Portal Vein Thrombosis Associated with Fusobacterium Nucleatum Septicemia in a Patient with Ulcerative Colitis

2004 ◽  
Vol 38 (7) ◽  
pp. 611-612 ◽  
Author(s):  
Elizabeth C Verna ◽  
Alberto Larghi ◽  
Sami G Faddoul ◽  
Jeffrey A Stein ◽  
Howard J Worman
Keyword(s):  
Ulcerative Colitis ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Fusobacterium Nucleatum ◽  
Vein Thrombosis
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