Anticoagulant therapy in patients with non-cirrhotic portal vein thrombosis: effect on new thrombotic events and gastrointestinal bleeding

2013 ◽  
Vol 11 (3) ◽  
pp. 452-459 ◽  
Author(s):  
M. C. W. Spaander ◽  
J. Hoekstra ◽  
B. E. Hansen ◽  
H. R. Van Buuren ◽  
F. W. G. Leebeek ◽  
...  
Keyword(s):  
Gastrointestinal Bleeding ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Anticoagulant Therapy ◽  
Vein Thrombosis

scholarly journals Safety of variceal band ligation in patients with cirrhosis and portal vein thrombosis treated with anticoagulant therapy

2020 ◽  
Vol 32 (3) ◽  
pp. 395-400
Author(s):  
Simon Ponthus ◽  
Laurent Spahr ◽  
Alessandro Casini ◽  
Thierry Berney ◽  
Jean-Louis Frossard ◽  
...  
Keyword(s):  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Anticoagulant Therapy ◽  
Band Ligation ◽  
Vein Thrombosis

scholarly journals Refractory bleeding from ectopic varices stopped by percutaneous transhepatic portal vein recanalization and stenting

2016 ◽  
Vol 3 (3) ◽  
pp. 52
Author(s):  
Guido Poggi ◽  
Cesare Massa Saluzzo ◽  
Benedetta Montagna ◽  
Chiara Picchi ◽  
Francesco Salerno
Keyword(s):  
Gastrointestinal Bleeding ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Stent Placement ◽  
Severe Bleeding ◽  
Jejunal Varices ◽  
Vein Thrombosis ◽  
Ectopic Varices

Ectopic varices is an uncommon cause of gastrointestinal bleeding. We reported a case of severe bleeding due to jejunal varices which arose as a complication of extrahepatic portal vein thrombosis. The patient was successfully treated by portal vein recanalization and  percutaneous transhepatic stent placement.

Current outcome of portal vein thrombosis in adults: Risk and benefit of anticoagulant therapy

2001 ◽  
Vol 120 (2) ◽  
pp. 490-497 ◽  
Author(s):  
Bertrand Condat ◽  
Fabienne Pessione ◽  
Sophie Hillaire ◽  
Marie-Helene Denninger ◽  
Marie-Claude Guillin ◽  
...  
Keyword(s):  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Anticoagulant Therapy ◽  
Vein Thrombosis ◽  
Risk And Benefit

scholarly journals Non Cirrhotic Portal Vein Thrombosis: Diagnostic and Therapeutic Challenge

2021 ◽  
Vol 22 (1) ◽  
pp. 79-83
Author(s):  
Syifa Mustika ◽  
Pratista Adi Krisna
Keyword(s):  
Gastrointestinal Bleeding ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Upper Gastrointestinal Bleeding ◽  
Recurrent Thrombosis ◽  
Common Cause ◽  
Vein Thrombosis ◽  
Physical Laboratory ◽  
Prevention And Treatment ◽  
Upper Gastrointestinal

Portal vein thrombosis (PVT), the second most common cause of portal hypertension, can be found in cirrhosis and non-cirrhosis patients. Various factors can cause non-cirrhosis PVT, such as biliary infection. Upper gastrointestinal bleeding without sign of liver failure, must be considered as non-cirrhosis PVT manifestation. Combining physical, laboratory, endoscopic and radiological examination is needed to establish the diagnosis of PVT. The principle of PVT management consists of 3 keypoints. They are prevention and treatment of gastrointestinal bleeding, prevention of recurrent thrombosis and portal cholangiopathy therapy. Many aspect should be considered regarding the administration of anticoagulants in PVT patients, especially chronic PVT with cavernomas.

scholarly journals Efficacy and safety of anticoagulant therapy in patients with chronic cirrhosis complicated with portal vein thrombosis: what should we expert from a meta-analysis?

2020 ◽  
Author(s):  
Yalin Liu ◽  
Wanwei Chen ◽  
Liangbi Xu ◽  
Haoyi Yang ◽  
Chenhong Duan ◽  
...  
Keyword(s):  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Anticoagulant Therapy ◽  
Meta Analysis ◽  
Anticoagulation Therapy ◽  
Cochrane Library ◽  
Efficacy And Safety ◽  
Bleeding Events ◽  
Vein Thrombosis ◽  
The Difference

Abstract Background: Systematic review and meta-analysis were performed to evaluate efficacy and safety of anticoagulant therapy in patients with chronic cirrhosis complicated with portal vein thrombosis (PVT). Methods: The PubMed, The Cochrane Library and Web of Science databases were searched. The odds ratio (OR) and risks ratio(RR) with 95% CI was pooled to calculate the difference in the rate of portal vein recanalization and occurrence of bleeding events between patients who received anticoagulation and those who did not. All meta-analysis were conducted by using a random-effects model. Results: 8 studies with a total of 559 patients published between 2005 and 2019 were finally enrolled in our meta-analysis . The rate of portal vein recanalization was significantly higher with PVT who received anticoagulation and those who did not (OR = 4.689, 95% (95% CI = 3.274–6.716, P=0.000). And the pooled risk ratio of bleeding between the two groups was 0.828 (95% CI = 0.511–1.343, P=0.444). The heterogeneity was not statistically significant among studies, Begg’s funnel plot and Egger’s linear regression test were performed to evaluate publicantion bias. Conclusion: Anticoagulation therapy can significantly improve the recanalization rate of PVT patients with cirrhosis, and the bleeding related events caused by anticoagulation are relatively low, which is worthy of clinical promotion. However, more prospective trials are needed to know how to use anticoagulants.

Non tumoral portal vein thrombosis during cirrhosis: Should anticoagulation be proposed?

2018 ◽  
Keyword(s):  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Anticoagulant Therapy ◽  
Control Group ◽  
Case Group ◽  
Early Introduction ◽  
Vein Thrombosis ◽  
History Of ◽  
One Year ◽  
The Impact

Background: Portal vein thrombosis (PVT) is considered as infrequent and pejorative event in cirrhosis. Up to date, many questions remain about therapeutic management. Aim: The objectives of this study were to assess the impact of the PVT on the progression of liver disease, to review the indications for anticoagulation and its repercussions. Materials and methods: A case-control study was conducted over a period of 12 years (2002-2013). It included 484 cases of cirrhosis. Among these patients, 41 had non tumoral portal vein thrombosis (case group). The control group included the remaining 443 patients. Results: In our study, there was no impact of PVT on the natural history of cirrhosis both in terms of complications or survival. Only the early introduction of anticoagulant therapy was associated with a re-permeabilization of portal vein at one year (OR1.6; 95% CI [1.10-2.01]). Prolonged anticoagulation was inversely correlated with recurrent PVT after treatment. However, obtaining a portal vein re-permeabilization was not correlated to a significant gain in terms of prevention of complication related to cirrhosis and survival. Conclusions: results suggest that portal vein thrombosis in patients with cirrhosis is not a formal indication for anticoagulant therapy. It should be reserved for candidates of liver transplantation, those with an extension of the PVT to mesenteric vessels or with severe prothrombotic status. Key words: portal vein thrombosis, cirrhosis, anticoagulation.

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