Hepatocanalicular injury associated with vitamin A derivative etretinate

1987 ◽  
Vol 32 (10) ◽  
pp. 1207-1211 ◽  
Author(s):  
Margaret R. Khouri ◽  
Scott H. Saul ◽  
Andrzej A. Dlugosz ◽  
Roger D. Soloway
Keyword(s):  
Vitamin A ◽  
Vitamin A Derivative

Multiple Congenital Malformations Associated with Maternal Isotretinoin Therapy

PEDIATRICS ◽  
1984 ◽  
Vol 74 (3) ◽  
pp. 428-430
Author(s):  
ELIZABETH DE LA CRUZ ◽  
SHYAN SUN ◽  
KAMTORN VANGVANICHYAKORN ◽  
FRANKIN DESPOSITO
Keyword(s):  
Vitamin A ◽  
Congenital Malformations ◽  
Cardiac Anomaly ◽  
Teratogenic Effects ◽  
Experimental Animals ◽  
Synthetic Vitamin ◽  
Extensive Information ◽  
Few Data ◽  
Vitamin A Derivative ◽  
Isotretinoin Therapy

Isotretinoin (Accutane), an oral synthetic vitamin A derivative, introduced in September 1982 by Roche Laboratories has been widely used in the treatment of recalcitrant cystic acne. Although there is extensive information regarding the teratogenic effects of excessive vitamin A in experimental animals,1 there are few data available on its possible effects in humans. We report a case of a preterm infant with microcephaly, microphthalmia, rudimentary pinnae, cardiac anomaly, and hepatocellular derangement born to a mother on isotretinoin therapy. This constellation of abnormalities mimicks the type of malformations seen in the animal models and is strongly suggestive of the teratogenicity of this drug to the human fetus.

Teratogenic Potential of Isotretinoin

1986 ◽  
Vol 8 (3) ◽  
pp. 68-94
Keyword(s):  
Animal Models ◽  
Vitamin A ◽  
Premature Infant ◽  
Congenital Anomalies ◽  
Pharmacologic Therapy ◽  
Multiple Congenital Anomalies ◽  
Keratolytic Agents ◽  
Teratogenic Potential ◽  
Vitamin A Derivative ◽  
Systemic Antibiotics

Pharmacologic therapy for acne, for the most part, consists of topical keratolytic agents and systemic antibiotics, but these modalities have had very little success in the treatment of cystic acne. In September 1982, isotretinoin, a Vitamin A derivative, was marketed for the treatment of recalcitrant acne and has proven to be efficacious. Because of the known teratogenicity of vitamin A in animal models, a manufacturer's warning was issued advising patients not to take this medication if they were pregnant or intended to become pregnant. Despite these warnings, there are reported cases of multiple congenital anomalies in infants born to mothers who took isotretinoin during the first half of pregnancy. Among the reported cases is a premature infant of 30 weeks' gestation born to a 22-year-old woman who used isotretinoin during her first 2 months of pregnancy.

scholarly journals Modulation of spectral properties and pump activity of proteorhodopsins by retinal analogues

2015 ◽  
Vol 467 (2) ◽  
pp. 333-343 ◽  
Author(s):  
Srividya Ganapathy ◽  
Odette Bécheau ◽  
Hanka Venselaar ◽  
Siebren Frölich ◽  
Jeroen B. van der Steen ◽  
...  
Keyword(s):  
Vitamin A ◽  
Spectral Properties ◽  
Proton Pumps ◽  
Pump Activity ◽  
Retinal Analogues ◽  
Vitamin A Derivative ◽  
Absorbance Band

Microbial proteorhodopsins are light-driven proton pumps, using the vitamin A derivative retinal as chromophore. We show that retinal analogues can shift their absorbance band with preservation of functionality. This may provide attractive opportunities in biotechnology, optogenetics and as potential sensors.

scholarly journals Retinoic acid controls the homeostasis of pre-cDC–derived splenic and intestinal dendritic cells

2013 ◽  
Vol 210 (10) ◽  
pp. 1961-1976 ◽  
Author(s):  
Christopher A. Klebanoff ◽  
Sean P. Spencer ◽  
Parizad Torabi-Parizi ◽  
John R. Grainger ◽  
Rahul Roychoudhuri ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Retinoic Acid ◽  
Vitamin A ◽  
Critical Role ◽  
Mucosal Injury ◽  
Immune Deficiencies ◽  
Radiation Induced ◽  
Essential Nutrient ◽  
Vitamin A Derivative ◽  
Regulatory Functions

Dendritic cells (DCs) comprise distinct populations with specialized immune-regulatory functions. However, the environmental factors that determine the differentiation of these subsets remain poorly defined. Here, we report that retinoic acid (RA), a vitamin A derivative, controls the homeostasis of pre-DC (precursor of DC)–derived splenic CD11b+CD8α−Esamhigh DCs and the developmentally related CD11b+CD103+ subset within the gut. Whereas mice deprived of RA signaling significantly lost both of these populations, neither pre-DC–derived CD11b−CD8α+ and CD11b−CD103+ nor monocyte-derived CD11b+CD8α−Esamlow or CD11b+CD103− DC populations were deficient. In fate-tracking experiments, transfer of pre-DCs into RA-supplemented hosts resulted in near complete conversion of these cells into the CD11b+CD8α− subset, whereas transfer into vitamin A–deficient (VAD) hosts caused diversion to the CD11b−CD8α+ lineage. As vitamin A is an essential nutrient, we evaluated retinoid levels in mice and humans after radiation-induced mucosal injury and found this conditioning led to an acute VAD state. Consequently, radiation led to a selective loss of both RA-dependent DC subsets and impaired class II–restricted auto and antitumor immunity that could be rescued by supplemental RA. These findings establish a critical role for RA in regulating the homeostasis of pre-DC–derived DC subsets and have implications for the management of patients with immune deficiencies resulting from malnutrition and irradiation.

The Vitamin A derivative etretinate improves skin sclerosis in patients with systemic sclerosis

2004 ◽  
Vol 34 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Takaharu Ikeda ◽  
Koji Uede ◽  
Hideo Hashizume ◽  
Fukumi Furukawa
Keyword(s):  
Systemic Sclerosis ◽  
Vitamin A ◽  
Skin Sclerosis ◽  
Vitamin A Derivative

A sporadic elder case of erythrokeratodermia variabilis with a single base-pair transversion in GJB3 gene successfully treated with systemic vitamin A derivative

2014 ◽  
pp. n/a-n/a
Author(s):  
Risako Otaguchi ◽  
Tamihiro Kawakami ◽  
Maya Matsuoka ◽  
Satoko Kimura ◽  
Yoshinao Soma ◽  
...  
Keyword(s):  
Vitamin A ◽  
Base Pair ◽  
Single Base ◽  
Single Base Pair ◽  
Vitamin A Derivative

In vivo confocal Raman spectroscopy study of the vitamin A derivative perfusion through human skin

2016 ◽  
Author(s):  
Laurita dos Santos ◽  
Claudio A. Téllez Soto ◽  
Priscila P. Favero ◽  
Airton A. Martin
Keyword(s):  
Raman Spectroscopy ◽  
Vitamin A ◽  
Human Skin ◽  
Spectroscopy Study ◽  
Confocal Raman Spectroscopy ◽  
Confocal Raman ◽  
Vitamin A Derivative
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