scholarly journals Topical Application of a Vitamin A Derivative and Its Combination With Non-ablative Fractional Laser Potentiates Cutaneous Influenza Vaccination

2018 ◽  
Vol 9 ◽  
Author(s):  
Peiyu Li ◽  
Ji Wang ◽  
Miao Cao ◽  
Qiwen Deng ◽  
Shibo Jiang ◽  
...  
Keyword(s):  
Vitamin A ◽  
Influenza Vaccination ◽  
Topical Application ◽  
Fractional Laser ◽  
Ablative Fractional Laser ◽  
Vitamin A Derivative

scholarly journals Ablative fractional laser‐assisted photodynamic therapy for lentigo maligna: a prospective pilot study

2019 ◽  
Vol 34 (3) ◽  
pp. 510-517
Author(s):  
J.E. Räsänen ◽  
N. Neittaanmäki ◽  
L. Jeskanen ◽  
I. Pölönen ◽  
E. Snellman ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Pilot Study ◽  
Fractional Laser ◽  
Lentigo Maligna ◽  
Prospective Pilot Study ◽  
Ablative Fractional Laser

Multiple Congenital Malformations Associated with Maternal Isotretinoin Therapy

PEDIATRICS ◽  
1984 ◽  
Vol 74 (3) ◽  
pp. 428-430
Author(s):  
ELIZABETH DE LA CRUZ ◽  
SHYAN SUN ◽  
KAMTORN VANGVANICHYAKORN ◽  
FRANKIN DESPOSITO
Keyword(s):  
Vitamin A ◽  
Congenital Malformations ◽  
Cardiac Anomaly ◽  
Teratogenic Effects ◽  
Experimental Animals ◽  
Synthetic Vitamin ◽  
Extensive Information ◽  
Few Data ◽  
Vitamin A Derivative ◽  
Isotretinoin Therapy

Isotretinoin (Accutane), an oral synthetic vitamin A derivative, introduced in September 1982 by Roche Laboratories has been widely used in the treatment of recalcitrant cystic acne. Although there is extensive information regarding the teratogenic effects of excessive vitamin A in experimental animals,1 there are few data available on its possible effects in humans. We report a case of a preterm infant with microcephaly, microphthalmia, rudimentary pinnae, cardiac anomaly, and hepatocellular derangement born to a mother on isotretinoin therapy. This constellation of abnormalities mimicks the type of malformations seen in the animal models and is strongly suggestive of the teratogenicity of this drug to the human fetus.

Teratogenic Potential of Isotretinoin

1986 ◽  
Vol 8 (3) ◽  
pp. 68-94
Keyword(s):  
Animal Models ◽  
Vitamin A ◽  
Premature Infant ◽  
Congenital Anomalies ◽  
Pharmacologic Therapy ◽  
Multiple Congenital Anomalies ◽  
Keratolytic Agents ◽  
Teratogenic Potential ◽  
Vitamin A Derivative ◽  
Systemic Antibiotics

Pharmacologic therapy for acne, for the most part, consists of topical keratolytic agents and systemic antibiotics, but these modalities have had very little success in the treatment of cystic acne. In September 1982, isotretinoin, a Vitamin A derivative, was marketed for the treatment of recalcitrant acne and has proven to be efficacious. Because of the known teratogenicity of vitamin A in animal models, a manufacturer's warning was issued advising patients not to take this medication if they were pregnant or intended to become pregnant. Despite these warnings, there are reported cases of multiple congenital anomalies in infants born to mothers who took isotretinoin during the first half of pregnancy. Among the reported cases is a premature infant of 30 weeks' gestation born to a 22-year-old woman who used isotretinoin during her first 2 months of pregnancy.

The Effect of Topical Application of Vitamin A with Special Reference to the Senile Skin

Dermatology ◽  
1954 ◽  
Vol 108 (2) ◽  
pp. 121-128 ◽  
Author(s):  
Frederick Reiss ◽  
Ross M. Campbell
Keyword(s):  
Vitamin A ◽  
Special Reference ◽  
Topical Application

Topical Application of Vitamin A Acid in Acne Vulgaris

1974 ◽  
Vol 67 (6) ◽  
pp. 683-687 ◽  
Author(s):  
LINWOOD G. BRADFORD ◽  
LEOPOLDO F. MONTES
Keyword(s):  
Vitamin A ◽  
Topical Application ◽  
Acne Vulgaris ◽  
Vitamin A Acid
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