Effect of islet hormones on secretin-stimulated exocrine secretion in isolated perfused rat pancreas

1993 ◽  
Vol 38 (7) ◽  
pp. 1278-1283 ◽  
Author(s):  
Hiroshi Hasegawa ◽  
Yoshinori Okabayashi ◽  
Makoto Koide ◽  
Yoshiaki Kido ◽  
Toshio Okutani ◽  
...  
Keyword(s):  
Exocrine Secretion ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas ◽  
Islet Hormones

scholarly journals Age-associated changes in pancreatic exocrine secretion of the isolated perfused rat pancreas

2013 ◽  
Vol 29 (1) ◽  
pp. 19 ◽  
Author(s):  
Zheng-er Jiang ◽  
ChengZhe Jiang ◽  
Baihui Chen ◽  
Chin Su Koh ◽  
Jun-Hwan Yong ◽  
...  
Keyword(s):  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas ◽  
Pancreatic Exocrine

Proglumide Analogues CR 1409 and CR 1392 Inhibit Cholecystokinin-Stimulated Insulin Release More Potently Than Exocrine Secretion from the Isolated Perfused Rat Pancreas

Pancreas ◽  
1990 ◽  
Vol 5 (3) ◽  
pp. 291-297 ◽  
Author(s):  
Yoshinori Okabayashi ◽  
Makoto Otsuki ◽  
Takahiko Nakamura ◽  
Masatoshi Fujii ◽  
Satoshi Tani ◽  
...  
Keyword(s):  
Insulin Release ◽  
Exocrine Secretion ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas

Effects of porcine secretin on exocrine and endocrine function in the isolated perfused rat pancreas

1981 ◽  
Vol 241 (1) ◽  
pp. G43-G48
Author(s):  
M. Otsuki ◽  
C. Sakamoto ◽  
A. Ohki ◽  
H. Yuu ◽  
S. Morita ◽  
...  
Keyword(s):  
Pancreatic Juice ◽  
Exocrine Secretion ◽  
Endocrine Function ◽  
Immunoreactive Insulin ◽  
Amylase Secretion ◽  
Perfused Rat Pancreas ◽  
Amylase Release ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas ◽  
Amylase Output

The effects of both synthetic and pure natural porcine secretin on immunoreactive insulin (IRI) and immunoreactive glucagon (IRG) release and on pancreatic exocrine secretion were studied in the isolated perfused rat pancreas. Synthetic porcine secretin stimulated a significant increase in pancreatic juice flow and amylase output at concentrations as low as 0.01 and 0.1 ng/ml, respectively. The maximal peak rate of both juice flow and amylase output was observed at 1 microgram/ml synthetic secretin. Synthetic secretin at concentrations up to 2 micrograms/ml and pure natural porcine secretin at a concentration of 1 clinical unit/ml had no effect on IRI secretion regardless of the glucose concentration (50, 100, or 150 mg/100 ml) in the perfusate. Both types of secretin, however, elicited a concentration-dependent increase in IRG secretion in the presence of 50 mg/100 ml glucose. The lowest synthetic secretin concentration causing a significant increase in IRG release was 0.1 ng/ml, and maximal stimulation was observed at 1 microgram/ml. These concentrations were similar to those eliciting minimal and maximal amylase release. Thus, synthetic and pure natural porcine secretin have been shown to not only stimulate pancreatic juice flow and amylase secretion but also to elicit IRG release from the isolated perfused rat pancreas.

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