Effects of intrapancreatic neuronal activation on cholecystokinin-induced exocrine secretion of isolated perfused rat pancreas

1999 ◽  
Vol 437 (4) ◽  
pp. 511-516 ◽  
Author(s):  
Hyung Seo Park ◽  
In Sun Park ◽  
Yun Lyul Lee ◽  
Hyeok Yil Kwon ◽  
H. J. Park
Keyword(s):  
Exocrine Secretion ◽  
Neuronal Activation ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas

scholarly journals Age-associated changes in pancreatic exocrine secretion of the isolated perfused rat pancreas

2013 ◽  
Vol 29 (1) ◽  
pp. 19 ◽  
Author(s):  
Zheng-er Jiang ◽  
ChengZhe Jiang ◽  
Baihui Chen ◽  
Chin Su Koh ◽  
Jun-Hwan Yong ◽  
...  
Keyword(s):  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas ◽  
Pancreatic Exocrine

Proglumide Analogues CR 1409 and CR 1392 Inhibit Cholecystokinin-Stimulated Insulin Release More Potently Than Exocrine Secretion from the Isolated Perfused Rat Pancreas

Pancreas ◽  
1990 ◽  
Vol 5 (3) ◽  
pp. 291-297 ◽  
Author(s):  
Yoshinori Okabayashi ◽  
Makoto Otsuki ◽  
Takahiko Nakamura ◽  
Masatoshi Fujii ◽  
Satoshi Tani ◽  
...  
Keyword(s):  
Insulin Release ◽  
Exocrine Secretion ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas

Effects of porcine secretin on exocrine and endocrine function in the isolated perfused rat pancreas

1981 ◽  
Vol 241 (1) ◽  
pp. G43-G48
Author(s):  
M. Otsuki ◽  
C. Sakamoto ◽  
A. Ohki ◽  
H. Yuu ◽  
S. Morita ◽  
...  
Keyword(s):  
Pancreatic Juice ◽  
Exocrine Secretion ◽  
Endocrine Function ◽  
Immunoreactive Insulin ◽  
Amylase Secretion ◽  
Perfused Rat Pancreas ◽  
Amylase Release ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas ◽  
Amylase Output

The effects of both synthetic and pure natural porcine secretin on immunoreactive insulin (IRI) and immunoreactive glucagon (IRG) release and on pancreatic exocrine secretion were studied in the isolated perfused rat pancreas. Synthetic porcine secretin stimulated a significant increase in pancreatic juice flow and amylase output at concentrations as low as 0.01 and 0.1 ng/ml, respectively. The maximal peak rate of both juice flow and amylase output was observed at 1 microgram/ml synthetic secretin. Synthetic secretin at concentrations up to 2 micrograms/ml and pure natural porcine secretin at a concentration of 1 clinical unit/ml had no effect on IRI secretion regardless of the glucose concentration (50, 100, or 150 mg/100 ml) in the perfusate. Both types of secretin, however, elicited a concentration-dependent increase in IRG secretion in the presence of 50 mg/100 ml glucose. The lowest synthetic secretin concentration causing a significant increase in IRG release was 0.1 ng/ml, and maximal stimulation was observed at 1 microgram/ml. These concentrations were similar to those eliciting minimal and maximal amylase release. Thus, synthetic and pure natural porcine secretin have been shown to not only stimulate pancreatic juice flow and amylase secretion but also to elicit IRG release from the isolated perfused rat pancreas.

The Role of Insulin in the Interaction of Secretin and Cholecystokinin in Exocrine Secretion of the Isolated Perfused Rat Pancreas

Pancreas ◽  
1996 ◽  
Vol 12 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Yun Lyul Lee ◽  
Hyeok Yil Kwon ◽  
Hyung Seo Park ◽  
Tae Hyung Lee ◽  
Hyoung Jin Park
Keyword(s):  
Exocrine Secretion ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas

scholarly journals Effects of γ-aminobutyric acid on secretagogue-induced exocrine secretion of isolated, perfused rat pancreas

2000 ◽  
Vol 279 (4) ◽  
pp. G677-G682 ◽  
Author(s):  
Hyung Seo Park ◽  
Hyoung Jin Park
Keyword(s):  
Receptor Antagonist ◽  
Electrical Field Stimulation ◽  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Electrical Field ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas ◽  
Pancreatic Exocrine ◽  
Somatostatin Antagonist

Because GABA and its related enzymes have been determined in β-cells of pancreas islets, effects of GABA on pancreatic exocrine secretion were investigated in the isolated, perfused rat pancreas. GABA, given intra-arterially at concentrations of 3, 10, 30, and 100 μM, did not exert any influence on spontaneous or secretin (12 pM)-induced pancreatic exocrine secretion. However, GABA further elevated CCK (10 pM)-, gastrin-releasing peptide (100 pM)-, or electrical field stimulation-induced pancreatic secretions of fluid and amylase dose dependently. The GABA (30 μM)-enhanced CCK-induced pancreatic secretions were completely blocked by bicuculline (10 μM), a GABAA receptor antagonist, but were not affected by saclofen (10 μM), a GABAB receptor antagonist. The enhancing effects of GABA (30 μM) on CCK-induced pancreatic secretions were not changed by tetrodotoxin (1 μM) but were partially reduced by cyclo-(7-aminoheptanonyl-Phe-d-Trp-Lys-Thr[BZL]) (10 nM), a somatostatin antagonist. In conclusion, GABA enhances pancreatic exocrine secretion induced by secretagogues, which predominantly induce enzyme secretion, via GABAA receptors in the rat pancreas. The enhancing effect of GABA is partially mediated by inhibition of islet somatostatin release.

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