Opposite effects of naloxone on substance P-induced changes in brain dopa synthesis and in locomotor activity in rats

1979 ◽  
Vol 45 (3) ◽  
pp. 185-193 ◽  
Author(s):  
J. A. Garcia-Sevilla ◽  
T. Magnusson ◽  
A. Carlsson
Keyword(s):  
Locomotor Activity ◽  
Substance P ◽  
Induced Changes

Stress-Induced Changes in Cholecystokinin and Substance P Concentrations in Discrete Regions of the Rat Hypothalamus

1987 ◽  
Vol 46 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Richard A. Siegel ◽  
Eva-Maria Düker ◽  
Ulrich Pahnke ◽  
Wolfgang Wuttke
Keyword(s):  
Substance P ◽  
Rat Hypothalamus ◽  
Induced Changes

scholarly journals Vortioxetine Differentially Modulates MK-801-Induced Changes in Visual Signal Detection Task Performance and Locomotor Activity

2018 ◽  
Vol 9 ◽  
Author(s):  
Todd M. Hillhouse ◽  
Christina R. Merritt ◽  
Douglas A. Smith ◽  
Manuel Cajina ◽  
Connie Sanchez ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Signal Detection ◽  
Task Performance ◽  
Detection Task ◽  
Visual Signal ◽  
Mk 801 ◽  
Signal Detection Task ◽  
Induced Changes

Neuropeptides degranulate serous cells of ferret tracheal glands

1986 ◽  
Vol 251 (2) ◽  
pp. C223-C229 ◽  
Author(s):  
A. A. Gashi ◽  
D. B. Borson ◽  
W. E. Finkbeiner ◽  
J. A. Nadel ◽  
C. B. Basbaum
Keyword(s):  
Substance P ◽  
Gland Cell ◽  
Secretory Granules ◽  
Light And Electron Microscopy ◽  
Base Line ◽  
Mucous Cells ◽  
Percent Change ◽  
Submucosal Glands ◽  
Muscarinic Cholinergic ◽  
Induced Changes

To determine whether serous or mucous cells in tracheal submucosal glands respond to the neuropeptides substance P (SP) and vasoactive intestinal peptide (VIP), we studied the peptide-induced changes in gland cell morphology accompanying release of 35SO4-labeled macromolecules from tracheal explants of ferrets. Explants were labeled for 1 h in medium containing 35SO4 and washed for 3.5 additional hours. Base-line secretion in the absence of drugs declined between 1.5 and 3.5 h after the pulse. Between 2.5 and 3.5 h, the average percent change in counts per minute recovered per sample period was not significantly different from zero (P greater than 0.3; n = 6). Substance P (10(-5) M) and VIP (2 X 10(-6) M) added 4 h after labeling each increased greatly the release of 35SO4-labeled macromolecules (SP, 219%; VIP, 180%) above base line. Bethanechol, a muscarinic-cholinergic agonist (10(-5) M), increased secretion by an average of 142% above base line (each effect, P less than 0.05; n = 6 each). Light and electron microscopy of the control tissues showed glands with narrow lumens and numerous secretory granules. Glands treated with SP or VIP had enlarged lumens and the serous cells were markedly degranulated. These phenomena were documented by morphometry and suggest that SP and VIP cause secretion from glands at least partially by stimulating exocytosis from serous cells.

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