Stress-induced changes in respiratory quotient, energy expenditure and locomotor activity in rats: effects of midazolam

1994 ◽  
Vol 116 (4) ◽  
pp. 475-482 ◽  
Author(s):  
Iain S. McGregor ◽  
Andrew M. Lee ◽  
R. F. Westbrook
Keyword(s):  
Locomotor Activity ◽  
Energy Expenditure ◽  
Respiratory Quotient ◽  
Induced Changes

scholarly journals Effect of raw and encapsulated policosanol on lipid profiles, blood biochemistry, activity, energy expenditure and macronutrient metabolism of adult cats

2021 ◽  
pp. 1098612X2110137
Author(s):  
James R Templeman ◽  
Kylie Hogan ◽  
Alexandra Blanchard ◽  
Christopher PF Marinangeli ◽  
Alexandra Camara ◽  
...  
Keyword(s):  
Body Weight ◽  
Energy Expenditure ◽  
Indirect Calorimetry ◽  
Respiratory Quotient ◽  
Blood Count ◽  
Complete Blood Count ◽  
Serum Biochemistry ◽  
Blood Collection ◽  
Adult Cats ◽  
Activity Energy

Objectives The objective of this study was to verify the safety of policosanol supplementation for domestic cats. The effects of raw and encapsulated policosanol were compared with positive (L-carnitine) and negative (no supplementation) controls on outcomes of complete blood count, serum biochemistry, energy expenditure, respiratory quotient and physical activity in healthy young adult cats. Methods The study was a replicated 4 × 4 complete Latin square design. Eight cats (four castrated males, four spayed females; mean age 3.0 ± 1.0 years; mean weight 4.36 ± 1.08 kg; mean body condition score 5.4 ± 1.4) were blocked by sex and body weight then randomized to treatment groups: raw policosanol (10 mg/kg body weight), encapsulated policosanol (50 mg/kg body weight), L-carnitine (200 mg/kg body weight) or no supplementation. Treatments were supplemented to a basal diet for 28 days with a 1-week washout between periods. Food was distributed equally between two offerings to ensure complete supplement consumption (first offering) and measure consumption time (second offering). Blood collection (lipid profile, complete blood count, serum biochemistry) and indirect calorimetry (energy expenditure, respiratory quotient) were conducted at days 0, 14 and 28 of each period. Activity monitors were worn 7 days prior to indirect calorimetry and blood collection. Data were analyzed using a repeated measures mixed model (SAS, v.9.4). Results Food intake and body weight were similar among treatments. There was no effect of treatment on lipid profile, serum biochemistry, activity, energy expenditure or respiratory quotient ( P >0.05); however, time to consume a second meal was greatest in cats fed raw policosanol ( P <0.05). Conclusions and relevance These data suggest that policosanol is safe for feline consumption. Further studies with cats demonstrating cardiometabolic risk factors are warranted to confirm whether policosanol therapy is an efficacious treatment for hyperlipidemia and obesity.

scholarly journals Effects of photoperiod on daily locomotor activity, energy expenditure, and feeding behavior in a seasonal mammal

2010 ◽  
Vol 298 (5) ◽  
pp. R1409-R1416 ◽  
Author(s):  
Amy Warner ◽  
Preeti H. Jethwa ◽  
Catherine A. Wyse ◽  
Helen I'Anson ◽  
John M. Brameld ◽  
...  
Keyword(s):  
Body Weight ◽  
Locomotor Activity ◽  
Energy Expenditure ◽  
Feeding Behavior ◽  
Heat Production ◽  
Prolonged Exposure ◽  
Dark Phase ◽  
Daily Rhythms ◽  
Dark Cycle ◽  
Activity Energy

The objective of this study was to determine whether the previously observed effects of photoperiod on body weight in Siberian hamsters were due to changes in the daily patterns of locomotor activity, energy expenditure, and/or feeding behavior. Adult males were monitored through a seasonal cycle using an automated comprehensive laboratory animal monitoring system (CLAMS). Exposure to a short-day photoperiod (SD; 8:16-h light-dark cycle) induced a significant decline in body weight, and oxygen consumption (V̇o2), carbon dioxide production (V̇co2), and heat production all decreased reaching a nadir by 16 wk of SD. Clear daily rhythms in locomotor activity, V̇o2, and V̇co2 were observed at the start of the study, but these all progressively diminished after prolonged exposure to SD. Rhythms in feeding behavior were also detected initially, reflecting an increase in meal frequency but not duration during the dark phase. This rhythm was lost by 8 wk of SD exposure such that food intake was relatively constant across dark and light phases. After 18 wk in SD, hamsters were transferred to a long-day photoperiod (LD; 16:8-h light-dark cycle), which induced significant weight gain. This was associated with an increase in energy intake within 2 wk, while V̇o2, V̇co2, and heat production all increased back to basal levels. Rhythmicity was reestablished within 4 wk of reexposure to long days. These results demonstrate that photoperiod impacts on body weight via complex changes in locomotor activity, energy expenditure, and feeding behavior, with a striking loss of daily rhythms during SD exposure.

scholarly journals Non-invasive stimulation of vagal afferents reduces gastric frequency

2019 ◽  
Author(s):  
Vanessa Teckentrup ◽  
Sandra Neubert ◽  
João C. P. Santiago ◽  
Manfred Hallschmid ◽  
Martin Walter ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Vagus Nerve ◽  
Energy Homeostasis ◽  
Resting Energy Expenditure ◽  
Vagal Afferents ◽  
Metabolic Effects ◽  
Net Energy ◽  
Non Invasive ◽  
Induced Changes ◽  
Stimulation Of

AbstractMetabolic feedback between the gut and the brain relayed via the vagus nerve contributes to energy homeostasis. We investigated in healthy adults whether non-invasive stimulation of vagal afferents impacts energy homeostasis via efferent effects on metabolism or digestion. In a randomized crossover design, we applied transcutaneous auricular vagus nerve stimulation (taVNS) while recording efferent metabolic effects using simultaneous electrogastrography (EGG) and indirect calorimetry. We found that taVNS reduced gastric myoelectric frequency (p =.008), but did not alter resting energy expenditure. We conclude that stimulating vagal afferents induces gastric slowing via vagal efferents without acutely affecting net energy expenditure at rest. Collectively, this highlights the potential of taVNS to modulate digestion by activating the dorsal vagal complex. Thus, taVNS-induced changes in gastric frequency are an important peripheral marker of brain stimulation effects.

Physical capacity, respiratory quotient and energy expenditure during exercise in male patients with schizophrenia compared with healthy controls

2012 ◽  
Vol 27 (3) ◽  
pp. 206-212 ◽  
Author(s):  
B.M. Nilsson ◽  
R.M. Olsson ◽  
A. Öman ◽  
F.-A. Wiesel ◽  
L. Ekselius ◽  
...  
Keyword(s):  
Weight Gain ◽  
Energy Expenditure ◽  
Oxygen Uptake ◽  
Maximal Oxygen Uptake ◽  
Respiratory Quotient ◽  
Physical Capacity ◽  
Healthy Controls ◽  
Uptake Capacity ◽  
Everyday Activity ◽  
Male Patients

AbstractBackgroundDespite massive research on weight gain and metabolic complications in schizophrenia there are few studies on energy expenditure and no current data on physical capacity.AimTo determine oxygen uptake capacity, respiratory quotient (RQ) and energy expenditure during a submaximal exercise test in patients with schizophrenia and healthy controls.MethodTen male patients and 10 controls were included. RQ and energy expenditure were investigated with indirect calorimetry during a cycle ergometer test. The submaximal work level was defined by heart rate and perceived exhaustion. Physical capacity was determined from predicted maximal oxygen uptake capacity (VO2-max).ResultsThe patients exhibited significantly higher RQ on submaximal workloads and lower physical capacity. A significant lower calculated VO2-max remained after correction for body weight and fat free mass (FFM). Energy expenditure did not differ on fixed workloads.ConclusionRQ was rapidly increasing in the patients during exercise indicating a faster transition to carbohydrate oxidation and anaerobic metabolism that also implies a performance closer to maximal oxygen uptake even at submaximal loads. This may restrict the capacity for everyday activity and exercise and thus contribute to the risk for weight gain. Physical capacity was consequently significantly lower in the patients.

Introduction of adult cats to indirect calorimetry respiration chambers causes increased energy expenditure and respiratory quotient that decrease following acclimation

2022 ◽  
pp. 1-6
Author(s):  
Kylie Hogan ◽  
Nicholas Genova ◽  
James R. Templeman ◽  
Adronie Verbrugghe ◽  
Anna K. Shoveller
Keyword(s):  
Energy Expenditure ◽  
Home Environment ◽  
Indirect Calorimetry ◽  
Repeated Measures ◽  
Respiratory Quotient ◽  
Mixed Model ◽  
Significant Variable ◽  
Level Energy ◽  
Adult Cats ◽  
Space Restriction

Abstract OBJECTIVE To replicate a previously defined behavioral procedure to acclimate adult cats to temporary restriction in indirect calorimetry chambers and measure energy expenditure and respiratory quotient changes during acclimation. ANIMALS 8 healthy adult cats (4 spayed females, and 4 neutered males; mean ± SEM age, 2.5 ± 1.5 years; mean body weight, 4.8 ± 1.8 kg). PROCEDURES Cats underwent a 13-week incremental acclimation procedure whereby cats were acclimated to the chambers in their home environment (weeks 1 to 3), to the study room (weeks 4 to 6), and to increasing lengths of restriction within their home environment (weeks 7 to 8) and the chambers (weeks 9 to 13). Cat stress score, respiratory rate, fearfulness (assessed with a novel object test), energy expenditure, and respiratory quotient were measured. Data were analyzed by use of a repeated-measures mixed model. RESULTS Stress, based on cat stress scores, fearfulness, and respiration, peaked at weeks 4, 9, and 10 but returned to baseline levels by week 11. Energy expenditure and respiratory quotient peaked at weeks 10 and 11, respectively, but were reduced significantly by weeks 11 and 13, respectively. All cats returned to baseline by the end of the study and were deemed fully acclimated. CLINICAL RELEVANCE Changes in perceived stress level, energy expenditure, and respiratory quotient at various stages of the acclimation procedure suggest that stress should be considered a significant variable in energy balance measurements when indirect calorimetry is used in cats. An incremental acclimation procedure should therefore be used to prepare cats for the temporary space restriction necessary for indirect calorimetry studies.

scholarly journals Measuring Energy Expenditure Independent Of The Respiratory Quotient During Rest And Exercise

2020 ◽  
Vol 52 (7S) ◽  
pp. 35-35
Author(s):  
Seif A. Alshakah ◽  
John R. Macaulay ◽  
Paul Gerges ◽  
Stella Crall ◽  
Marshall D. McCue ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Respiratory Quotient ◽  
Rest And Exercise

scholarly journals A Single Dose of Goji Berries Does Not Affect Postprandial Energy Expenditure and Substrate Oxidation in Healthy, Overweight Men

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
José J. van den Driessche ◽  
Jogchum Plat ◽  
Guy Plasqui ◽  
Ronald P. Mensink
Keyword(s):  
Oxygen Consumption ◽  
Single Dose ◽  
Glucose Metabolism ◽  
Energy Expenditure ◽  
Respiratory Quotient ◽  
Substrate Oxidation ◽  
Caloric Content ◽  
Lycium Barbarum ◽  
Meal Intake ◽  
Postprandial Energy Expenditure

Background and Aim. Increasing energy expenditure is an effective strategy for the prevention of obesity. In this respect, Lycium barbarum (goji berry) is of interest, as it has been shown to increase postprandial oxygen consumption. Although this suggests that energy expenditure was also increased, energy expenditure and substrate oxidation can only be assessed accurately when both oxygen consumption and carbon dioxide production are measured. We therefore investigated the effects of a single dose of Lycium barbarum fruit on postprandial energy expenditure and substrate oxidation in a randomized, double-blind crossover trial. In addition, markers of lipid and glucose metabolism were measured. Methods. Seventeen healthy, overweight men received in a random order a meal containing 25 grams of dried Lycium barbarum fruit or a control meal matched for caloric content and macronutrient composition. Energy expenditure and the respiratory quotient were determined using indirect calorimetry before and up to 4 hours after meal intake. Blood was sampled before and after meal intake at regular intervals for analyses of plasma glucose, serum triacylglycerol, and free fatty acid concentrations. Results. Energy expenditure significantly increased after the Lycium barbarum and control meal, but no differences were found between the meals (p=0.217). Postprandial changes in respiratory quotient (p=0.719) and concentrations of glucose (p=0.663), triacylglycerol (p=0.391), and free fatty acids (p=0.287) were also not affected by Lycium barbarum intake. Conclusions. A single dose of Lycium barbarum does not affect postprandial energy expenditure, substrate oxidation, and markers for lipid and glucose metabolism in healthy, overweight men.

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