Destruction of myelin in the central nervous system of experimental animals by enzymatic activity of vaccinia virus

1953 ◽  
Vol 5 (2) ◽  
pp. 73-83 ◽  
Author(s):  
J. D. Verlinde ◽  
E. Vries ◽  
A. Kret
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Enzymatic Activity ◽  
Vaccinia Virus ◽  
Experimental Animals ◽  
The Central Nervous System

Letters to the Editor

PEDIATRICS ◽  
1982 ◽  
Vol 69 (1) ◽  
pp. 129-129
Author(s):  
John M. Graham
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Early Pregnancy ◽  
Letters To The Editor ◽  
Experimental Animals ◽  
The Central Nervous System ◽  
Predominant Effect

In general, I agree with the comments expressed above. We did not intend to imply that the pattern of neuromotor dysfunction was in any way specific to gestational hyperthermia. What we find provocative about our study is that the timing of gestational hyperthermia in the human, and the defects associated with such hyperthermia, are very similar to the timing and defects which are seen in experimental animals. In fact, the studies by Edwards (cited in our paper) would appear to suggest that the predominant effect of prolonged hyperthermia during early pregnancy is on the central nervous system.

Trichobilharzia regenti, a pathogen of the avian and mammalian central nervous systems

Parasitology ◽  
1999 ◽  
Vol 119 (6) ◽  
pp. 577-581 ◽  
Author(s):  
P. HORÁK ◽  
J. DVOŘÁK ◽  
L. KOLÁŘOVÁ ◽  
L. TREFIL
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Final Host ◽  
Host Factors ◽  
Experimental Animals ◽  
Central Nervous Systems ◽  
Avian Schistosomes ◽  
The Central Nervous System ◽  
Trichobilharzia Regenti

The development of nasal avian schistosomes of the genus Trichobilharzia in their final host is poorly known. Therefore, an experimental infection of ducklings (Anas platyrhynchos f. dom.) by T. regenti was performed. The infection resulted in leg paralysis and orientation/balance disorders of birds. The examination of the duck's spinal cord and brain confirmed the presence of developing parasites in pre-patent as well as patent periods. The absence of the worms in other tissues strongly supports our hypothesis that the parasite migrates through the central nervous system (CNS) to its final location in bird nasal mucosa. The injury level is probably dependent on number of parasites as well as yet unknown host factors. The affinity to the CNS seems to be high; also by exposure of experimental animals to low cercarial doses the growing worms in the CNS were found. In addition to the generally accepted view that bird schistosomes may cause cercarial dermatitis of mammals (including man), there is evidence of a partial development of T. regenti in mouse CNS; in certain cases leg paralysis was also recorded. Therefore, the pathogenesis spectrum caused by bird schistosomes in birds/mammals needs to be reconsidered.

scholarly journals ACTIONS OF DESOXYNUPHARIDINE HYDROCHLORIDE IN THE CENTRAL NERVOUS SYSTEM OF EXPERIMENTAL ANIMALS (I)

1981 ◽  
Vol 31 (3) ◽  
pp. 391-400
Author(s):  
Yukiko SUZUKI ◽  
Yukihiko HAGIWARA ◽  
Kyoji TAGUCHI ◽  
Kazuyo KAJIYAMA ◽  
Takato IKEDA
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Experimental Animals ◽  
The Central Nervous System

scholarly journals Histochemical demonstration of neurotoxic esterase.

1989 ◽  
Vol 37 (5) ◽  
pp. 589-596 ◽  
Author(s):  
G B Koelle ◽  
N S Thampi ◽  
M S Han ◽  
E J Olajos
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Enzymatic Activity ◽  
Histochemical Demonstration ◽  
The Other ◽  
Delayed Neurotoxicity ◽  
The Central Nervous System ◽  
Cryostat Sections ◽  
Insoluble Precipitate ◽  
Neurotoxic Esterase

We developed a histochemical method for localizing neurotoxic esterase (NTE), defined as the phenylvalerate (PV)-hydrolyzing esterase that is resistant to 40 microM paraoxon (A) but inactivated by paraoxon plus 50 microM mipafox (B). NTE is considered to be the target enzyme in the production of organophosphorus ester-induced delayed neurotoxicity (OPIDN). Cryostat sections were incubated in a medium containing alpha-naphthyl valerate and 6-benzamido-4-methoxy-m-toluidine diazonium chloride (fast violet B) after treatment with the above-mentioned inhibitors, leading to formation of an aqueous insoluble precipitate at sites of enzymatic activity. NTE activity was estimated as staining detectable in A but not in B. In the central nervous system (CNS) of chicken, NTE appeared to be present primarily in the somata of most neurons, but at sites indistinguishable from those of the other inhibitor-resistant and -sensitive alpha-naphthyl valerate-hydrolyzing esterases. It could not be distinguished in the CNS of cat, probably because it constitutes less than 3% of the total PV-hydrolyzing activity in the CNS of that species.

scholarly journals Effects of a new psychotropic agent, CS-430, on the central nervous system of experimental animals.

1978 ◽  
Vol 74 (7) ◽  
pp. 857-870
Author(s):  
Nobuyoshi IWATA ◽  
Kazuo KOBAYASHI ◽  
Takao HARA ◽  
Masako MATSUMURA ◽  
Naoji Mikuni ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Experimental Animals ◽  
Psychotropic Agent ◽  
The Central Nervous System

scholarly journals Magnetic resonance imaging, microscopy, and spectroscopy of the central nervous system in experimental animals

NeuroRx ◽  
2005 ◽  
Vol 2 (2) ◽  
pp. 250-264 ◽  
Author(s):  
Istvan Pirko ◽  
Stanley Thomas Fricke ◽  
Aaron J. Johnson ◽  
Moses Rodriguez ◽  
Slobodan I. Macura
Keyword(s):  
Magnetic Resonance Imaging ◽  
Central Nervous System ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Experimental Animals ◽  
The Central Nervous System
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