Calcitonin receptors on neoplastic mononuclear cells cultured from a human giant-cell tumor of the sacrum

1994 ◽  
Vol 120 (5) ◽  
pp. 272-278 ◽  
Author(s):  
Akio Maeda ◽  
Hisao Matsui ◽  
Masahiko Kanamori ◽  
Kazuo Yudoh ◽  
Haruo Tsuji
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Mononuclear Cells ◽  
Cell Tumor ◽  
Calcitonin Receptors ◽  
Cells Cultured

scholarly journals Response of mononuclear cells cultured from giant cell tumor of bone to hyperthermia.

1989 ◽  
Vol 38 (2) ◽  
pp. 770-774
Author(s):  
Setsuro Komiya ◽  
Masanori Nakashima ◽  
Saburo Yamamoto ◽  
Iwao Yanagida ◽  
Akio Inoue ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Mononuclear Cells ◽  
Cell Tumor ◽  
Cells Cultured

Giant Cell Poor Extra-Articular Diffuse-Type Tenosynovial Giant Cell Tumor With Extensive Desmin Expression: A Potential Diagnostic Pitfall With Cytogenetic Confirmation

2018 ◽  
Vol 27 (1) ◽  
pp. 59-61
Author(s):  
Liurka Lopez ◽  
Karen Schoedel ◽  
Ivy John
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Mononuclear Cells ◽  
Giant Cells ◽  
Cell Tumor ◽  
Diffuse Type ◽  
Tenosynovial Giant Cell Tumor ◽  
Diagnostic Pitfall

Diffuse-type tenosynovial giant cell tumor can rarely present as an entirely extra-articular mass, which can be misdiagnosed as a sarcoma especially when giant cells are absent, dominated by large dendritic mononuclear cells, and desmin expression is extensive.

Giant Cell Tumor of Tendon Sheath: Immunohistochemical Study of 20 Cases

1997 ◽  
Vol 83 (5) ◽  
pp. 841-846 ◽  
Author(s):  
Antonio Cavaliere ◽  
Angelo Sidoni ◽  
Emilio Bucciarelli
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Mononuclear Cells ◽  
Neuron Specific Enolase ◽  
Synovial Cell ◽  
Tendon Sheath ◽  
Giant Cells ◽  
Cell Tumor ◽  
Electron Microscopic ◽  
Filament Bundles

Aims and background Giant cell tumor of tendon sheath (GCTTS) is a common tumor occurring on the tendon sheaths of the fingers. The nature of this lesion is still controversial: some researchers consider it a reactive process arising from chronic inflammation while others regard it as a tumor of presumed synovial cell or monocytic macrophage system origin. In an effort to clarify the histogenesis we decided to further investigate the immunophenotypic profile of this tumor. Study design We studied 20 GCTTS of the fingers using a panel of 18 antibodies, 13 monoclonal and 5 polyclonal. Results The immunohistochemical investigation revealed that the mononuclear cells of this lesion can be divided into two groups. The cells of the first and more numerous group were positive for vimentin, PG-M1 and KP1 but also for muscle actin (HHF35 monoclonal antibody) and neuron-specific enolase. A second population of mononuclear cells, usually arranged around the giant cells, were positive for PG-M1, KP1, LCA and occasionally for alpha-1-antitrypsin and alpha-1-antichymotrypsin. Multinucleated giant cells were also positive for KP1, PG-M1 and LCA monoclonal antibodies. A variable but usually weak positivity for al-pha-1-antitrypsin, alpha-1-antichymotrypsin and lysozyme was also observed. Conclusions Our results suggest a synovial cell origin for GCTTS and do not support the hypothesis that it could be a neoplasm with a true histiocytic origin. The positivity of some cells for the HHF35 antibody, together with electron microscopic evidence of filament bundles with focal dense bodies, suggests that at least part of the mononuclear cells may have a myofibroblastic differentiation.

Histomorphometric Analysis of Pre- and Post-Denosumab–Treated Giant Cell Tumor of Bone

2020 ◽  
Vol 28 (8) ◽  
pp. 859-867
Author(s):  
Nasir Ud Din ◽  
Masood Umer ◽  
Yong-Koo Park
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Stromal Cells ◽  
Mononuclear Cells ◽  
Giant Cells ◽  
Cell Tumor ◽  
P Value ◽  
Osteoblastic Activity ◽  
Woven Bone ◽  
Hematoxylin And Eosin

Context. Denosumab is a monoclonal antibody against RANK ligand. Its administration in giant cell tumor of bone (GCTB) cases results in elimination of giant cells and new bone formation. Neoplastic stromal cells of GCTB harbor mutation of histone 3.3 and have pre-osteoblastic properties and thus express SATB2. Objectives. To (1) analyze histological changes in post-denosumab–treated GCTB, (2) analyze expression of H3.3G34W and SATB2 in pre- and post-denosumab–treated samples, and (3) to discuss why changes occur in the expression of not only H3.3G34W but also SATB2. Materials and Methods. Hematoxylin and eosin slides of 19 cases of denosumab-treated GCTB were reviewed. Immunohistochemical stains H3.3G34W and SATB2 were performed. The number of positive mononuclear cells were counted and graded. Results. Complete absence of osteoclast-like giant cells (OCLGCs) was noted in most cases along with a fibro-osseous component merging with peripheral shell of reactive bone. Irregular trabeculae of woven bone and osteoid with focal osteoblastic rimming was seen. Spindle cells were arranged predominantly in fascicular pattern. Morphometric analysis of H3.3G34W showed a mean of 68.8% positive stromal cells in pretreatment and a mean of 26.9% positive stromal cells in posttreated specimens with a statistically significant P value (.001). Mean percentage of SATB2-positive stromal cells in the pre- and posttreatment specimens was 36.46% and 20.8%, respectively. Conclusions. Our study validates that denosumab treatment results in marked reduction of OCLGCs with increased osteoblastic activity. Decreased expression of H3.3G34W in posttreatment may be a result of decreased antigenicity of neoplastic mononuclear cells. No significant change in SATB2 expression was noted.

Giant Cell Tumor of Soft Tissue with Pulmonary Metastases: Pathologic and Cytogenetic Study

2005 ◽  
Vol 8 (6) ◽  
pp. 718-724 ◽  
Author(s):  
Hua Guo ◽  
Roberto A. Garcia ◽  
Mary Ann Perle ◽  
John Amodio ◽  
M. Alba Greco
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Mononuclear Cells ◽  
Chromosomal Abnormalities ◽  
Cytogenetic Study ◽  
Giant Cells ◽  
Cell Tumor ◽  
General Acceptance ◽  
Telomeric Association

Giant cell tumor of soft tissue (GCTST) has gained general acceptance as an uncommon but distinct primary soft tissue tumor since it was first described in 1972. GCTST is predominantly seen in adults and typically shows uniformly dispersed osteoclast-like giant cells admixed with oval to polygonal mononuclear cells. It usually follows a benign clinical course, although the malignant variant has been described in cases in which the mononuclear cells demonstrate obvious dysplastic features. It is still not clear whether the two variants belong to the spectrum of the same tumor. No cytogenetic chromosomal abnormalities have been reported in the literature of GCTST. Interestingly, the osseous counterpart of giant cell tumor, which shares similar histologic features, quite often displays a telomeric association at the cytogenetic level, a finding that has never been reported in GCTST. We report the case of a 12-year-old girl with GCTST of the right leg that metastasized to the lung. Cytogenetic studies from the primary tumor showed the phenomenon of telomeric association involving multiple chromosomes.

scholarly journals Primary mediastinal giant cell tumor

Rare Tumors ◽  
2009 ◽  
Vol 1 (2) ◽  
pp. 141-142
Author(s):  
Judd Goldberg ◽  
Shameen Azizad ◽  
Jela Bandovic ◽  
Arfa Khan
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Mononuclear Cells ◽  
English Literature ◽  
Giant Cells ◽  
Posterior Mediastinum ◽  
Cell Tumor ◽  
Distinct Entity ◽  
Posterior Mediastinal

Giant cell tumor of soft tissue is a rare tumor first described by Salm and Sissons in 1972 as being a distinct entity. 1 Histologically, it is composed of multinucleated giant cells dispersed among mononuclear cells, and is indistinguishable from its bone equivalent. 2 The majority of these tumors have been reported to occur in the lower extremity. 2 , 3 We describe a case of giant cell tumor of soft tissue within the posterior mediastinum. The only other report of a primary mediastinal giant cell tumor of soft tissue in the English literature was published by Fu et al. in 2002, in which they described two patients with posterior mediastinal masses. 4

scholarly journals Stromal Cell-Derived CCL20 Promotes Tumor Progression and Osteolysis in Giant Cell Tumor of Bone

2018 ◽  
Vol 51 (5) ◽  
pp. 2472-2483 ◽  
Author(s):  
Chenglong Zhao ◽  
Dongsheng Wang ◽  
Liang Tang ◽  
Zhichao Zhang ◽  
Song Li ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Mononuclear Cells ◽  
Bone Destruction ◽  
Cell Tumor ◽  
Migration Ability ◽  
And Migration ◽  
Proliferation And Migration

Background/Aims: Giant cell tumor of bone (GCTB), one of the most common primary bone tumors, leads to extensive bone destruction. However, the mechanisms underlying GCTB progression remain elusive and prognostic factors and treatment targets are required. In the current study, we explored the function of the chemokine family member CCL20 in GCTB progression. Methods: We explored the expression of CCL20 in stromal cells (GCTSCs) using microarray. Clinical analyses of the role of CCL20 in tumor progression were performed based on the patient cohort of our institution. The role of CCL20 in tumor proliferation was evaluated by MTS assay, migration ability was measured by a Transwell assay, and osteoclastogenesis was induced by CCL20 or GCTSC-conditioned medium. Quantitative PCR and western blot were used to measure the expression levels of mRNAs and proteins related to tumor progression. Results: CCL20 was upregulated in GCTSCs and correlated with tumor progression and prognosis. CCL20 induced GCTSC proliferation and migration in an autocrine manner. In addition, CCL20 recruited mononuclear cells and induced osteoclastogenesis by overactivating the AKT and NF-κB signaling pathways. Antibody blockade of CCL20 abolished the exacerbated osteoclastogenesis. Conclusion: Taken together, our data indicate that GCTSC secretion of CCL20 acts as a key modulator in the pathological progression of GCTB. It can promote GCTSC proliferation and migration in an autocrine manner and can recruit bone marrow monocytes to the tumor microenvironment and enhance osteoclastogenesis in a paracrine manner. These findings strongly indicate the potential prognostic and therapeutic value of CCL20 in GCTB.

Giant cell tumor of soft tissue originating from the thyroid: a case report and literature review

2020 ◽  
Author(s):  
Jianrong Chen ◽  
Haiyong Zhang ◽  
Xiufang Li ◽  
Mengjun Hu ◽  
Huan Lei ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Soft Tissues ◽  
Mononuclear Cells ◽  
Giant Cells ◽  
Cell Tumor ◽  
Case Presentation ◽  
Uncommon Neoplasm ◽  
Atypical Mitosis

Abstract Background: Giant cell tumor of soft tissues (GCT-ST) is a low malignant uncommon neoplasm, with is histological and immunophenotype similar to that of GCT of bone. Primary giant cell tumor of soft tissue arising in the thyroid is exceedingly rare. Case presentation: We reported a new case of GCT-ST originating from the thyroid occurring in 69-year-old woman. Histologically, the tumor was composed of two morphological components, mononuclear cells admixed with multinucleated osteoclast-like giant cells. Tumor is devoid of atypia, pleomorphism, and atypical mitosis. Immunohistochemically, the tumor cells showed strongly positivity with antibodies to CD68, but were negative for AE1/AE3, EMA and additional muscle markers. Conclusions: Due to its rare occurrence, we analyzed the clinical features of patients with primary thyroid GCT-ST to summarize some of our experiences and conduct a literature. The interest of this case lies in the rarity of this entity, the difficulty in preoperative diagnosis, and the confusion with other malignancies.

scholarly journals Giant Cell Tumor of Lower End of Tibia

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Monish Bami ◽  
Ashok R. Nayak ◽  
Shreepad Kulkarni ◽  
Avinash Kulkarni ◽  
Rupali Gupta
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Ankle Joint ◽  
Mononuclear Cells ◽  
Full Range ◽  
Cell Tumor ◽  
Lytic Lesion ◽  
Primary Tumors ◽  
Vesicular Nucleus ◽  
Left Ankle

Introduction. Giant cell tumor of bones is an unusual neoplasm that accounts for 4% of all primary tumors of bone, and it represents about 10% of malignant primary bone tumors with its different grades from borderline to high grade malignancy.Case Report. A 35-year-old patient presented with complains of pain and swelling in left ankle since 1 year following a twisting injury to his left ankle. On examination, swelling was present over the distal and anterior part of leg and movements of ankle joint were normal. All routine blood investigations were normal. X-ray and CT ankle showed morphology of subarticular well-defined expansile lytic lesion in lower end of left tibia suggestive of giant cell tumor. Histopathology of the tissue shows multinucleated giant cells with uniform vesicular nucleus and mononuclear cells which are spindle shaped with uniform vesicular nucleus suggestive of GCT. The patient was treated by excision, curettage, and bone cement to fill the defect.Conclusion. The patient at 12-month followup is doing well and walking without any pain comfortably and with full range of motion at ankle joint with articular congruity maintained and no signs of recurrences.

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