scholarly journals Hole of plasma free fatty acids in the control of insulin secretion in man

Diabetologia ◽  
1973 ◽  
Vol 9 (2) ◽  
pp. 145-151 ◽  
Author(s):  
E. O. Balasse ◽  
H. A. Ooms
Keyword(s):  
Fatty Acids ◽  
Insulin Secretion ◽  
Free Fatty Acids ◽  
Plasma Free Fatty Acids

Evidence for an Hepatic Anti-Ketogenic Effect of Insulin in Man

1978 ◽  
Vol 55 (5) ◽  
pp. 499-504 ◽  
Author(s):  
R. S. Elkeles ◽  
R. A. Chalmers ◽  
J. Hambley
Keyword(s):  
Fatty Acids ◽  
Insulin Secretion ◽  
Free Fatty Acids ◽  
Direct Effect ◽  
Normal Subjects ◽  
Oral Glucose ◽  
Plasma Free Fatty Acids ◽  
Sharp Fall ◽  
Plasma Ffa ◽  
Effect Of Glucose

1. Infusion of a triglyceride emulsion (Intralipid) into overnight fasted normal subjects produced a rise in plasma free fatty acids (FFA) and blood ketones. 2. Glucose given orally 60 min after the start of the Intralipid infusion produced a sharp fall in blood ketones without much change in plasma FFA. 3. An infusion of glucagon given together with Intralipid did not alter the reduction in blood ketones produced by oral glucose in normal subjects. 4. Oral glucose given 60 min after the start of the Intralipid infusion in three insulin-requiring diabetic subjects produced no fall in blood ketones. 5. The results suggest that glucose prevents the increase in blood ketones after Intralipid through an increase in insulin secretion rather than through a suppression of glucagon or as a direct effect of glucose. 6. It is most likely that the effect of insulin is to inhibit hepatic ketogenesis.

scholarly journals A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes

Diabetes ◽  
2003 ◽  
Vol 52 (10) ◽  
pp. 2461-2474 ◽  
Author(s):  
S. Kashyap ◽  
R. Belfort ◽  
A. Gastaldelli ◽  
T. Pratipanawatr ◽  
R. Berria ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Insulin Secretion ◽  
Free Fatty Acids ◽  
Plasma Free Fatty Acids ◽  
Develop Type ◽  
Sustained Increase

scholarly journals Associations of Free Fatty Acids With Insulin Secretion and Action Among African-American and European-American Girls and Women

Obesity ◽  
2010 ◽  
Vol 18 (2) ◽  
pp. 247-253 ◽  
Author(s):  
Laura Lee T. Goree ◽  
Betty E. Darnell ◽  
Robert A. Oster ◽  
Marian A. Brown ◽  
Barbara A. Gower
Keyword(s):  
Fatty Acids ◽  
African American ◽  
Insulin Secretion ◽  
Free Fatty Acids ◽  
European American

Source of plasma free fatty acids in dogs receiving fat emulsion and heparin

1963 ◽  
Vol 204 (4) ◽  
pp. 691-695 ◽  
Author(s):  
H. C. Meng ◽  
B. Edgren
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Lipolytic Activity ◽  
Blocking Agent ◽  
Fat Emulsion ◽  
Similar Reduction ◽  
Plasma Free Fatty Acids ◽  
Fat Infusion ◽  
Plasma Ffa ◽  
Slight Rise

Unanesthetized dogs were given either 3.0 g fat/kg as a 20% fat emulsion or heparin (2 mg/kg) intravenously or both. Plasma free fatty acids (FFA) and lipolytic activity were determined at intervals. In some experiments hexamethonium (5 mg/kg), a sympathetic ganglionic blocking agent, was administered intravenously either before or after fat or heparin. In fasting dogs fat infusion produced a moderate and heparin caused a slight rise in plasma FFA. Heparin given during lipemia produced a marked elevation of plasma FFA. The plasma lipolytic activity was increased after fat emulsion or heparin. Hexamethonium reduced the fasting plasma FFA about 70% or 0.40–0.6 mEq/liter. A similar reduction of plasma FFA also was observed when hexamethonium was administered during fat infusion or after heparin. Hexamethonium did not affect the increase in plasma lipolytic activity following the administration of fat emulsion or heparin. It seems probable that the increase in plasma FFA observed after intravenous infusion of fat emulsion or heparin is mainly due to the result of intravascular lipolysis.

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