Influence of Plasma Free Fatty Acids on Lipoprotein Synthesis and Diabetic Dyslipidemia

2003 ◽  
Vol 111 (05) ◽  
pp. 246-250 ◽  
Author(s):  
U. Julius
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Diabetic Dyslipidemia ◽  
Plasma Free Fatty Acids ◽  
Lipoprotein Synthesis

Source of plasma free fatty acids in dogs receiving fat emulsion and heparin

1963 ◽  
Vol 204 (4) ◽  
pp. 691-695 ◽  
Author(s):  
H. C. Meng ◽  
B. Edgren
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Lipolytic Activity ◽  
Blocking Agent ◽  
Fat Emulsion ◽  
Similar Reduction ◽  
Plasma Free Fatty Acids ◽  
Fat Infusion ◽  
Plasma Ffa ◽  
Slight Rise

Unanesthetized dogs were given either 3.0 g fat/kg as a 20% fat emulsion or heparin (2 mg/kg) intravenously or both. Plasma free fatty acids (FFA) and lipolytic activity were determined at intervals. In some experiments hexamethonium (5 mg/kg), a sympathetic ganglionic blocking agent, was administered intravenously either before or after fat or heparin. In fasting dogs fat infusion produced a moderate and heparin caused a slight rise in plasma FFA. Heparin given during lipemia produced a marked elevation of plasma FFA. The plasma lipolytic activity was increased after fat emulsion or heparin. Hexamethonium reduced the fasting plasma FFA about 70% or 0.40–0.6 mEq/liter. A similar reduction of plasma FFA also was observed when hexamethonium was administered during fat infusion or after heparin. Hexamethonium did not affect the increase in plasma lipolytic activity following the administration of fat emulsion or heparin. It seems probable that the increase in plasma FFA observed after intravenous infusion of fat emulsion or heparin is mainly due to the result of intravascular lipolysis.

Small Doses of Subcutaneous Heparin, Plasma Free-Fatty-Acids, and the Incidence of Ventricular Arrhythmias in Patients with Acute Myocardial Infarction

1979 ◽  
Author(s):  
H. Arnesen ◽  
Ø. Skjæggestad ◽  
N. Wik
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Ventricular Arrhythmias ◽  
Prospective Trial ◽  
Plasma Free Fatty Acids ◽  
Vein Thrombosis ◽  
Subcutaneous Heparin ◽  
Small Doses

The frequency of deep vein thrombosis (DVT) diagnosed with the 125I-fibrinogen technique in patients with acute myocardial infarction (AMI) has been found to be reduced frcm about 20% without anticoagulation to about 5% with warfarin or small doses of subcutaneous heparin.A somewhat higher incidence of ventricular tachycardia in patients with AMI treated with small doses of subcutaneous heparin has been reported. A possible mechanism might be heparin-induced activation of lipoprotein lipase with consequent increase of plasma free-fatty-acids (FFA), which have been found to be arrhythmogenic in patients with AMI.In the present prospective trial, 99 patients with AMI and a history of less than 12 hours were allocated at random to treatment with subcutaneous heparin 5000 IU twice daily, or warfarin. In a randomized subsample of 21 patients fasting FFA analyses were performed before and 2 hours after the administration of anticoagulants on day 1 and 2.No measurable increase in FFA concentrations was demonstrated in the heparin-treated patients, in spite of a significant influence on the thrombin clotting time.The frequency of ventricular arrhythmias as detected by continous tape recordings was equal in the two treatment groups.It is concluded that subcutaneous heparin 5 000 IU every 12 hours seems to be a safe measures of prophylaxis against venous thromboembolic ccmplications in patients with AMI.

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