scholarly journals Blood glucose regulation using an open-loop insulin delivery system in pancreatectomized dogs given glucose infusions

Diabetologia ◽  
1979 ◽  
Vol 16 (2) ◽  
pp. 129-133 ◽  
Author(s):  
A. M. Albisser ◽  
C. K. Botz ◽  
B. S. Leibel
Keyword(s):  
Blood Glucose ◽  
Delivery System ◽  
Insulin Delivery ◽  
Open Loop ◽  
Glucose Regulation ◽  
Blood Glucose Regulation ◽  
Insulin Delivery System ◽  
Pancreatectomized Dogs

scholarly journals Blood glucose regulation using closed- and open-loop insulin delivery systems

Diabetologia ◽  
1979 ◽  
Vol 17 (1) ◽  
pp. 45-49 ◽  
Author(s):  
C. K. Botz ◽  
E. B. Marliss ◽  
A. M. Albisser
Keyword(s):  
Blood Glucose ◽  
Insulin Delivery ◽  
Delivery Systems ◽  
Open Loop ◽  
Glucose Regulation ◽  
Blood Glucose Regulation

scholarly journals An Intelligent Nanoscale Insulin Delivery System

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2945 ◽  
Author(s):  
Wei Wang ◽  
Ling Liao ◽  
Xiaobing Zhang ◽  
Fan Lei ◽  
Yaou Zhang ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Delivery System ◽  
Glucose Monitoring ◽  
Insulin Delivery ◽  
Insulin Injection ◽  
The Body ◽  
Blood Glucose Monitoring ◽  
Nanoscale Material ◽  
Insulin Delivery System

Insulin injection relies on strict blood glucose monitoring. However, existing techniques and algorithms for blood glucose monitoring cannot be completed in a timely way. In this study, we have developed a new intelligent glucose-sensitive insulin delivery system to stabilize blood glucose levels in the body. This system does not require real-time detection of blood glucose. First, we successfully synthesized a nanoscale material called PAM-PAspPBA-b-PEG by using chemical methods. We then conducted TEM, DLS, and 1H-NMR analyses to characterize the physicochemical properties, such as size, molecular composition, and configuration of the nanomaterial. We verified the glucose responsibility of the insulin loading nanoscale material in vitro and evaluated its safety and effect on mice in vivo. Results showed that insulin-loaded PAM-PAspPBA-b-PEG is glucose-sensitive, safer and more effective than regular insulin injection. This study provides a basis for future development of smart insulin delivery systems.

1065-P: The Effect of a Closed-Loop Insulin Delivery System on Glycemic Control in Type 1 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1065-P ◽  
Author(s):  
ANASTASIOS KOUTSOVASILIS ◽  
ALEXIOS SOTIROPOULOS ◽  
ANASTASIA ANTONIOU ◽  
VASILIOS KORDINAS ◽  
DESPINA PAPADAKI ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Delivery System ◽  
Closed Loop ◽  
Insulin Delivery ◽  
Insulin Delivery System
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