scholarly journals Blood glucose control and insulin clearance in unrestrained diabetic dogs portally infused with a portable insulin delivery system

Diabetologia ◽  
1980 ◽  
Vol 19 (5) ◽  
pp. 452-457 ◽  
Author(s):  
Y. Goriya ◽  
A. Bahoric ◽  
E. B. Marliss ◽  
B. Zinman ◽  
A. M. Albisser
Keyword(s):  
Blood Glucose ◽  
Delivery System ◽  
Glucose Control ◽  
Blood Glucose Control ◽  
Insulin Delivery ◽  
Insulin Clearance ◽  
Insulin Delivery System ◽  
Diabetic Dogs

scholarly journals An Intelligent Nanoscale Insulin Delivery System

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2945 ◽  
Author(s):  
Wei Wang ◽  
Ling Liao ◽  
Xiaobing Zhang ◽  
Fan Lei ◽  
Yaou Zhang ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Delivery System ◽  
Glucose Monitoring ◽  
Insulin Delivery ◽  
Insulin Injection ◽  
The Body ◽  
Blood Glucose Monitoring ◽  
Nanoscale Material ◽  
Insulin Delivery System

Insulin injection relies on strict blood glucose monitoring. However, existing techniques and algorithms for blood glucose monitoring cannot be completed in a timely way. In this study, we have developed a new intelligent glucose-sensitive insulin delivery system to stabilize blood glucose levels in the body. This system does not require real-time detection of blood glucose. First, we successfully synthesized a nanoscale material called PAM-PAspPBA-b-PEG by using chemical methods. We then conducted TEM, DLS, and 1H-NMR analyses to characterize the physicochemical properties, such as size, molecular composition, and configuration of the nanomaterial. We verified the glucose responsibility of the insulin loading nanoscale material in vitro and evaluated its safety and effect on mice in vivo. Results showed that insulin-loaded PAM-PAspPBA-b-PEG is glucose-sensitive, safer and more effective than regular insulin injection. This study provides a basis for future development of smart insulin delivery systems.

scholarly journals Diabetic Chronic Hyperglycemia and Neurologic Outcome following Global Ischemia in Dogs

1996 ◽  
Vol 16 (6) ◽  
pp. 1230-1235 ◽  
Author(s):  
Frederick E. Sieber ◽  
Lee J. Martin ◽  
P. Randall Brown ◽  
Sally C. Palmon ◽  
Richard J. Traystman
Keyword(s):  
Blood Glucose ◽  
Glucose Control ◽  
Cell Damage ◽  
Recovery Period ◽  
Blood Glucose Control ◽  
Superior Temporal Gyrus ◽  
Global Ischemia ◽  
Global Brain Ischemia ◽  
Chronic Hyperglycemia ◽  
Diabetic Dogs

We tested the hypothesis that the neuropathologic outcome following recovery from incomplete ischemia is similar in normoglycemia and diabetes. Incomplete global ischemia was induced for 20 min in two groups of dogs: (a) normoglycemic, nondiabetic controls (n = 11) and (b) chronic (3 months), diabetic hyperglycemic subjects (n = 12). Animals were allowed to recover from surgery for 7 days after which they were perfusion-fixed for neuropathology. On paraffin processed tissue stained with hematoxylin and eosin (H&E), ischemic neurons were counted and the per cent of cell damage determined. All control animals survived for 7 days postischemia. Four of 12 diabetic animals survived for 7 days, with the remaining eight diabetic dogs dying within the first 3 days. On day 7, the percentage of neurons showing ischemic cell change in the four diabetic survivors and the 11 nondiabetic controls was similar in the cerebellum, CA1, superior temporal gyrus, and caudate. However, diabetic dogs that did not survive the 7-day recovery period showed cerebellar swelling, reduced Purkinje cell densities, and herniation. During the 3 months prior to ischemia, morning (10.7 ± 4.4 versus 11.2 ± 5.2 m M) and afternoon (8.8 ± 5.0 versus 9.4 ± 5.3 m M) blood glucose levels in the four surviving and eight nonsurviving diabetic animals, respectively, were similar. However, preischemic blood glucose was significantly elevated in animals that did not survive (7.8 ± 2.8 versus 15.8 ± 7.3 m M in survivors and nonsurvivors, respectively). This study shows that diabetic animals surviving 7 days postischemia and nondiabetic controls have similar neuropathology. However, diabetic animals in which glucose control deteriorated during the 24-h prior to ischemia did not survive, possibly due to severe hindbrain edema. These results show that in diabetes, blood glucose control immediately prior to incomplete global brain ischemia is an important determinant of morbidity and neuropathology.

Tight blood glucose control in T1DM via continuously adjusted insulin delivery based on frequent blood glucose sampling

2009 ◽  
Vol 33 (3) ◽  
pp. 295
Author(s):  
A.G. Gallardo-Hernandez ◽  
S.A. Islas-Andrade ◽  
M.C. Revilla-Monslave ◽  
L. Fridman ◽  
Y. Shtessel ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Control ◽  
Blood Glucose Control ◽  
Insulin Delivery

Automated insulin delivery - Continuous blood glucose control during ex situ liver perfusion

2020 ◽  
pp. 1-1 ◽  
Author(s):  
Dustin Becker ◽  
Dilmurodjon Eshmuminov ◽  
Roman Keller ◽  
Matteo Mueller ◽  
Lucia Bautista Borrego ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Control ◽  
Liver Perfusion ◽  
Blood Glucose Control ◽  
Insulin Delivery ◽  
Ex Situ
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