scholarly journals Sex related diurnal variations in venous blood glucose and plasma insulin levels effects of estrogens in men

Diabetologia ◽  
1974 ◽  
Vol 10 (6) ◽  
pp. 725-730 ◽  
Author(s):  
M. Hautecouverture ◽  
G. Slama ◽  
R. Assan ◽  
G. Tchobroutsky
Keyword(s):  
Blood Glucose ◽  
Plasma Insulin ◽  
Venous Blood ◽  
Diurnal Variations ◽  
Insulin Levels ◽  
Plasma Insulin Levels

scholarly journals Blood glucose, plasma insulin and sensory responses to guar-containing wheat breads: effects of molecular weight and particle size of guar gum

1991 ◽  
Vol 66 (3) ◽  
pp. 363-379 ◽  
Author(s):  
Peter R. Ellis ◽  
Fathy M. Dawoud ◽  
Edwin R. Morris
Keyword(s):  
Molecular Weight ◽  
Particle Size ◽  
Blood Glucose ◽  
Rheological Properties ◽  
Plasma Insulin ◽  
Guar Gum ◽  
Insulin Levels ◽  
Sensory Qualities ◽  
Plasma Insulin Levels

The effectiveness of guar gum in reducing post-prandial blood glucose and plasma insulin levels in human subjects seems to depend mainly on its ability to increase the viscosity of digesta in the small intestine. However, the precise relationship between the rheological properties of guar gum (either in vitro or in vivo) and the changes in blood metabolites and hormones is unknown. The aim of the present study, therefore, was to investigate the effects of wheat breads containing guar gum samples varying in molecular weight (Mw) and particle size (characteristics that strongly influence the rheological properties of guar gum) on post-prandial blood glucose and plasma insulin levels in healthy subjects. The sensory qualities of breads containing guar-gum flours of different Mw were also evaluated using a hedonic scoring technique. No significant differences in the post-prandial blood glucose responses were found between the control and guar breads. However, all the guar breads elicited significant (P < 0.05) decreases in the post-prandial rise in plasma insulin, an effect that did not appear to be influenced by large variations in Mw or particle size of guar gum. Moreover, the sensory qualities of guar bread were markedly improved by using low Mw grades of guar gum.

The effect of capsaicin on blood glucose, plasma insulin levels and insulin binding in dog models

2001 ◽  
Vol 15 (5) ◽  
pp. 391-394 ◽  
Author(s):  
I. Tolan ◽  
D. Ragoobirsingh ◽  
E. Y. St. A. Morrison
Keyword(s):  
Blood Glucose ◽  
Plasma Insulin ◽  
Insulin Binding ◽  
Insulin Levels ◽  
Plasma Insulin Levels ◽  
Glucose Plasma

scholarly journals Evidence that GLUT-2 mRNA and protein concentrations are decreased by hyperinsulinaemia and increased by hyperglycaemia in liver of diabetic rats

1992 ◽  
Vol 288 (2) ◽  
pp. 675-679 ◽  
Author(s):  
R Burcelin ◽  
M Eddouks ◽  
J Kande ◽  
R Assan ◽  
J Girard
Keyword(s):  
Blood Glucose ◽  
Plasma Insulin ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Insulin Infusion ◽  
Pancreatic Beta Cell ◽  
Diabetic Rats ◽  
Mrna Levels ◽  
Insulin Levels ◽  
Portal Plasma ◽  
Plasma Insulin Levels

GLUT-2, glucokinase (GK) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression was studied in the liver of chronically catheterized diabetic rats during the 3 days after an intravenous injection of 65 mg of streptozotocin (STZ)/kg. At 6 h after the STZ injection, portal plasma insulin levels were 270 +/- 32 mu-units/ml and blood glucose was 1.4 +/- 0.4 mmol/l, owing to pancreatic beta-cell destruction. GLUT-2 and PEPCK mRNA concentrations were rapidly and dramatically decreased (> 90%), whereas GK mRNA was increased. After 30 h, plasma insulin concentrations were lower than 5 mu-units/ml and blood glucose was > 20 mmol/l. GLUT-2 and PEPCK mRNA concentrations increased 2-fold and GK mRNA disappeared progressively. In order to assess the relative roles of hyperglycaemia and insulinopenia, blood glucose was clamped at 6.4 +/- 0.5 mmol/l from 18 to 72 h after STZ injection by phlorizin infusion (0.5-2 g/day per kg) or at 6.6 +/- 0.3 mmol/l from 18 to 48 h after STZ injection by insulin infusion (0.25 unit/min per kg). GLUT-2 mRNA concentrations were 50% lower in phlorizin-infused than in untreated diabetic rats. The low levels of GK mRNA and the high levels of PEPCK mRNA were unaffected by normalization of hyperglycaemia in phlorizin-infused diabetic rats. In insulin-infused rats (portal plasma insulin levels of 40 mu-units/ml) GLUT-2 mRNA levels were 25% of those in untreated diabetic rats, and they increased rapidly 6 h after insulin infusion was stopped. Liver GLUT-2 protein concentration showed similar changes in response to STZ injection and to phlorizin or insulin treatment, but after a delay of several hours. From this work we conclude that GLUT-2 gene expression is dramatically and rapidly (< 6 h) decreased by portal hyperinsulinaemia and increased by hyperglycaemia.

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