Recording the oscillatory potentials of the electroretinogram with the DTL electrode

1993 ◽  
Vol 83 (2) ◽  
pp. 119-130 ◽  
Author(s):  
Pierre Lachapelle ◽  
Julie Benoit ◽  
John M. Little ◽  
Beno�t Lachapelle
1999 ◽  
Vol 39 (6) ◽  
pp. 1069-1070 ◽  
Author(s):  
Marc Hébert ◽  
Vaegan ◽  
Pierre Lachapelle
Keyword(s):  

1991 ◽  
Vol 76 (4) ◽  
pp. 389-394 ◽  
Author(s):  
Xiao-Xin Li ◽  
Nin Yuan ◽  
Jie Hong ◽  
Pei Song

1991 ◽  
Vol 78 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Neal S Peachey ◽  
Kenneth R Alexander ◽  
Deborah J Derlacki ◽  
Phyllis Bobak ◽  
Gerald A Fishman

1993 ◽  
Vol 114 (2) ◽  
pp. 144-151 ◽  
Author(s):  
Nobuyoshi Nakatake ◽  
Aiko Hori ◽  
Akihiro Yasuhara ◽  
Hiroe Naito ◽  
Motohiro Yasuhara

2004 ◽  
Vol 91 (3) ◽  
pp. 1450-1454 ◽  
Author(s):  
P. Durante ◽  
C. G. Cardenas ◽  
J. A. Whittaker ◽  
S. T. Kitai ◽  
R. S. Scroggs

Ca2+ channel subtypes expressed by dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) were studied using whole cell patch-clamp recordings and blockers selective for different channel types (L, N, and P/Q). Nimodipine (Nim, 2 μM), ω-conotoxin GVIA (Ctx, 1 μM), or ω-agatoxin IVA (Atx, 50 nM) blocked 27, 36, and 37% of peak whole cell Ca2+ channel current, respectively, indicating the presence of L-, N-, and P-type channels. Nim blocked approximately twice as much Ca2+ channel current near activation threshold compared with Ctx or Atx, suggesting that small depolarizations preferentially opened L-type versus N- or P-type Ca2+ channels. N- and L-channels in DA neurons opened over a significantly more negative voltage range than those in rat dorsal root ganglion cells, recorded from using identical conditions. These data provide an explanation as to why Ca2+-dependent spontaneous oscillatory potentials and rhythmic firing in DA neurons are blocked by L-channel but not N-channel antagonists and suggest that pharmacologically similar Ca2+ channels may exhibit different thresholds for activation in different types of neurons.


2019 ◽  
Vol 4 (4) ◽  
pp. 91-95
Author(s):  
Yu. N. Savina ◽  
S. I. Zhukova ◽  
A. V. Korolenko ◽  
D. A. Averyanov

Arterial hypertension is a problem not only for adults, but also for children, but there are very few data on changes in the organ of vision under the influence of an elevated level of blood pressure in children.The aim of the work is to identify disturbances of the choroidal blood flow in children and adolescents with essential arterial hypertension.Methods. Fifty patients with essential arterial hypertension were examined. The age of patients ranged from 10 to 17 years, the duration of the disease ranged from 2 months to 8 years. All patients underwent color Doppler mapping of the orbital vessels, registration of the oscillatory potentials of the ERG.Results. It was revealed that increased arterial pressure causes retinal and choroidal ischemia, which is accompanied primarily by impaired blood flow in the orbital vessels and is reflected in a decrease in the amplitude and deformation of the peaks of the ERG oscillatory potentials.Conclusion. Hypertension causes and supports retinal and choroidal ischemia, which is accompanied primarily by impaired blood flow in the orbital vessels, functional depression of photoreceptors, ganglion cells and neuroglia of the retina, aggravating the identified changes as the experience of essential hypertension increases. A marker of chorioretinal ischemia is amplitude depression, a change in the shape of the teeth of the oscillatory potentials of the ERG, which indicates a decrease in the functional activity of the retinal ganglion complex.That is, these changes can be considered as a predictor of hypertensive angioretinopathy in children and adolescents with essential arterial hypertension.


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