Inhibitory effects by oral administration of ginsenoside Rh2 on the growth of human ovarian cancer cells in nude mice

1993 ◽  
Vol 120 (1-2) ◽  
pp. 24-26 ◽  
Author(s):  
T. Tode ◽  
Y. Kikuchi ◽  
T. Kita ◽  
J. Hirata ◽  
E. Imaizumi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Oral Administration ◽  
Cancer Cells ◽  
Nude Mice ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Ginsenoside Rh2 ◽  
Inhibitory Effects

scholarly journals Inhibitory Effects of Ginsenoside Rh2on Tumor Growth in Nude Mice Bearing Human Ovarian Cancer Cells

1998 ◽  
Vol 89 (7) ◽  
pp. 733-740 ◽  
Author(s):  
Hideyuki Nakata ◽  
Yoshihiro Kikuchi ◽  
Takehiko Tode ◽  
Junko Hirata ◽  
Tsunekazu Kita ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Nude Mice ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Inhibitory Effects

Synthetic Naphthoflavonoids Showing Inhibitory Effects on Clonogenicity against Cisplatin-Resistant A2780/Cis Human Ovarian Cancer Cells

2015 ◽  
Vol 12 (8) ◽  
pp. 628-639
Author(s):  
Yearam Jung ◽  
Soon Young Shin ◽  
Yeonjoong Yong ◽  
Hyuk Yoon ◽  
Seunghyun Ahn ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Inhibitory Effects

Adjuvant effects of antineoplastic prostaglandins to cisplatin in nude mice bearing human ovarian cancer cells

1992 ◽  
Vol 118 (6) ◽  
pp. 453-457 ◽  
Author(s):  
Y. Kikuchi ◽  
T. Kita ◽  
M. Miyauchi ◽  
J. Hirata ◽  
H. Sasa ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Nude Mice ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Adjuvant Effects

scholarly journals A novel small molecule LLL12B inhibits STAT3 signaling and sensitizes ovarian cancer cell to paclitaxel and cisplatin

2020 ◽  
Author(s):  
Ruijie Zhang ◽  
Xiaozhi Yang ◽  
Dana M. Roque ◽  
Chenglong Li ◽  
Jiayuh Lin
Keyword(s):  
Ovarian Cancer ◽  
Cell Viability ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Small Molecule ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Inhibitory Effects ◽  
Stat3 Signaling ◽  
Stat3 Phosphorylation

AbstractOvarian cancer is the fifth most common cause of cancer deaths among American women. Platinum and taxane combination chemotherapy represents the first-line approach for ovarian cancer, but treatment success is often limited by chemoresistance. Therefore, it is necessary to find new drugs to sensitize ovarian cancer cells to chemotherapy. Persistent activation of Signal Transducer and Activator of Transcription 3 (STAT3) signaling plays an important role in oncogenesis. Using a novel approach called advanced multiple ligand simultaneous docking (AMLSD), we developed a novel nonpeptide small molecule, LLL12B, which targets the STAT3 pathway. In this study, LLL12B inhibited STAT3 phosphorylation (tyrosine 705) and the expression of its downstream targets, which are associated with cancer cell proliferation and survival. We showed that LLL12B also inhibits cell viability, migration, and proliferation in human ovarian cancer cells. LLL12B combined with either paclitaxel or with cisplatin demonstrated synergistic inhibitory effects relative to monotherapy in inhibiting cell viability and LLL12B-paclitaxel or LLL12B-cisplatin combination exhibited greater inhibitory effects than cisplatin- paclitaxel combination in ovarian cancer cells. Furthermore, LLL12B-paclitaxel or LLL12B-cisplatin combination showed more significant in inhibiting cell migration and growth than monotherapy in ovarian cancer cells. In summary, our results support the novel small molecule LLL12B as a potent STAT3 inhibitor in human ovarian cancer cellsand suggest that LLL12B in combination with the current front-line chemotherapeutic drugs cisplatin and paclitaxel may represent a promising approach for ovarian cancer therapy.

Antitumor effect of monoclonal antibody-carboplatin conjugates in nude mice bearing human ovarian cancer cells

1999 ◽  
Vol 4 (4) ◽  
pp. 236-240 ◽  
Author(s):  
Y. Ota ◽  
Ichio Fukasawa ◽  
Hisashi Tokita ◽  
Tomohisa Yamaguchi ◽  
Haruo Yoshino ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Monoclonal Antibody ◽  
Cancer Cells ◽  
Nude Mice ◽  
Antitumor Effect ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer

Antitumor efficacy induced by human ovarian cancer cells secreting IL-21 alone or combination with GM-CSF cytokines in nude mice model

Immunobiology ◽  
2009 ◽  
Vol 214 (6) ◽  
pp. 483-492 ◽  
Author(s):  
Jun Dou ◽  
Yongfang Wang ◽  
Jing Wang ◽  
Fengshu Zhao ◽  
Yating Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Nude Mice ◽  
Antitumor Efficacy ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Mice Model ◽  
Gm Csf ◽  
Nude Mice Model
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