Effects of lymphokine-activated killer cells and interleukin-2 on the ascites formation and the survival time of nude mice bearing human ovarian cancer cells

1989 ◽  
Vol 115 (3) ◽  
pp. 217-220 ◽  
Author(s):  
Keibun Oomori ◽  
Yoshihiro Kikuchi ◽  
Munenori Miyauchi ◽  
Tsunekazu Kita ◽  
Ichiro Iwano ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Survival Time ◽  
Cancer Cells ◽  
Nude Mice ◽  
Interleukin 2 ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Lymphokine Activated Killer Cells ◽  
Killer Cells ◽  
Ascites Formation

Adjuvant effects of antineoplastic prostaglandins to cisplatin in nude mice bearing human ovarian cancer cells

1992 ◽  
Vol 118 (6) ◽  
pp. 453-457 ◽  
Author(s):  
Y. Kikuchi ◽  
T. Kita ◽  
M. Miyauchi ◽  
J. Hirata ◽  
H. Sasa ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Nude Mice ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Adjuvant Effects

Antitumor effect of monoclonal antibody-carboplatin conjugates in nude mice bearing human ovarian cancer cells

1999 ◽  
Vol 4 (4) ◽  
pp. 236-240 ◽  
Author(s):  
Y. Ota ◽  
Ichio Fukasawa ◽  
Hisashi Tokita ◽  
Tomohisa Yamaguchi ◽  
Haruo Yoshino ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Monoclonal Antibody ◽  
Cancer Cells ◽  
Nude Mice ◽  
Antitumor Effect ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer

scholarly journals Inhibitory Effects of Ginsenoside Rh2on Tumor Growth in Nude Mice Bearing Human Ovarian Cancer Cells

1998 ◽  
Vol 89 (7) ◽  
pp. 733-740 ◽  
Author(s):  
Hideyuki Nakata ◽  
Yoshihiro Kikuchi ◽  
Takehiko Tode ◽  
Junko Hirata ◽  
Tsunekazu Kita ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Nude Mice ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Inhibitory Effects

Antitumor efficacy induced by human ovarian cancer cells secreting IL-21 alone or combination with GM-CSF cytokines in nude mice model

Immunobiology ◽  
2009 ◽  
Vol 214 (6) ◽  
pp. 483-492 ◽  
Author(s):  
Jun Dou ◽  
Yongfang Wang ◽  
Jing Wang ◽  
Fengshu Zhao ◽  
Yating Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Nude Mice ◽  
Antitumor Efficacy ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Mice Model ◽  
Gm Csf ◽  
Nude Mice Model

scholarly journals CNDP2 Acts as an Activator for Human Ovarian Cancer Growth and Metastasis via the PI3K/AKT Pathway

2019 ◽  
Vol 18 ◽  
pp. 153303381987477
Author(s):  
Li Q. Zhang ◽  
Hua Q. Yang ◽  
Su Q. Yang ◽  
Ying Wang ◽  
Xian J. Chen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Nude Mice ◽  
Cancer Metastasis ◽  
Akt Pathway ◽  
Migration And Invasion ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Skov3 Cells ◽  
Cancer Tissues

Introduction: The mechanism of tumorigenesis and metastasis of ovarian cancer has not yet been elucidated. This study aimed to investigate the role and molecular mechanism of cytosolic nonspecific dipeptidase 2 in tumorigenesis and metastasis. Methods: Cytosolic nonspecific dipeptidase 2 expression in human ovarian cancer tissues and cell lines was assessed with methyl thiazolyl tetrazolium (MTT), clone formation, and transwell assays performed to evaluate the ability of ovarian cancer cells to proliferate and migrate. Nude mice tumor formation experiments were also performed by subcutaneously injecting cells with stable cytosolic nonspecific dipeptidase 2 knockdown and control SKOV3 cells into BALB/c female nude mice to detect changes in PI3K/AKT pathway-related proteins by Western blotting. Results: Cytosolic nonspecific dipeptidase 2 was highly expressed in human ovarian cancer tissues, with its expression associated with pathological data, including ovarian cancer metastasis. A cytosolic nonspecific dipeptidase 2 stable knockdown or ectopic expression ovarian cancer cell model was established and demonstrated that cytosolic nonspecific dipeptidase 2 could promote the proliferation of ovarian cancer cells. Transwell cell migration and invasion assays confirmed that cytosolic nonspecific dipeptidase 2 enhanced cell metastasis in ovarian cancer. Furthermore, in vivo xenograft experiments demonstrated that cytosolic nonspecific dipeptidase 2 can promote the development and progression of ovarian cancer, increasing the expression of phosphorylated PI3K and AKT. Conclusions: Cytosolic nonspecific dipeptidase 2 promotes the occurrence and development of ovarian cancer through the PI3K/AKT signaling pathway.

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