Content of dopamine in the nigrostriatal system during electrical stimulation of the caudate nucleus head

1981 ◽  
Vol 11 (4) ◽  
pp. 323-327
Author(s):  
S. I. Bazhenova ◽  
N. B. Saul'skaya
Keyword(s):  
Electrical Stimulation ◽  
Caudate Nucleus ◽  
Nigrostriatal System ◽  
Caudate Nucleus Head ◽  
Stimulation Of

Effects of Anticonvulsant Drugs upon Patterns of Seizure Discharge and Brain Thresholds: Some Implications for Memory Mechanisms

1968 ◽  
Vol 23 (3) ◽  
pp. 843-850 ◽  
Author(s):  
Harold C. Nielson ◽  
Don R. Justesen ◽  
Paul B. Porter
Keyword(s):  
Electrical Stimulation ◽  
Caudate Nucleus ◽  
Nerve Impulse ◽  
Anticonvulsant Drugs ◽  
Leg Flexion ◽  
Dissociation Of Learning ◽  
Stimulation Of

10 cats were trained to perform an avoidance leg flexion at a signal: electrical stimulation of the caudate nucleus or the centre median. Thresholds were found to be elevated by anticonvulsants. In 3 of these cats, seizure discharges were induced by stimulation of the hippocampus and recorded on an EEG. The data are interpreted as indicating alteration of nerve impulse pathways. It is argued that such alteration may underlie dissociation of learning produced by various drugs and states.

scholarly journals Evoked Neuronal Activity Accompanied by Transmitter Release Increases Oxygen Concentration in Rat Striatum in vivo but Not in vitro

1992 ◽  
Vol 12 (4) ◽  
pp. 629-637 ◽  
Author(s):  
Jayne B. Zimmerman ◽  
Robert T. Kennedy ◽  
R. Mark Wightman
Keyword(s):  
Electrical Stimulation ◽  
Caudate Nucleus ◽  
Neuronal Activity ◽  
Brain Slices ◽  
Rat Striatum ◽  
Initial Increase ◽  
Striatal Slices ◽  
Carbon Fiber Microelectrode ◽  
Stimulation Of

Dopamine and oxygen (O2) were measured in the caudate nucleus of anesthetized rats and in striatal slices during electrical stimulation. Simultaneous electrochemical detection of dopamine and O2 was accomplished with fast-scan cyclic voltammetry at a Nafion-coated carbon-fiber microelectrode. Stimulation of the medial forebrain bundle resulted in synaptic overflow of dopamine in the caudate nucleus. At the same time, O2 concentration increased in the extracellular fluid with two separate phases. The amplitude of the initial increase directly correlated with the frequency of the stimulus, with the time of maximum concentration reproducible across a range of frequencies. The second increase occurred at later times with a more random amplitude and with a broad, variable shape. Agents which blocked vasodilation affected both phases: Atropine attenuated the initial increase, while the second feature was nearly absent after theophylline. Yohimbine and α-methyl- p-tyrosine did not affect the O2 responses. Local electrical stimulation of the slice preparation also resulted in dopamine overflow, but a prolonged decrease in O2 concentration accompanied this event. Striatal field stimulation in vivo produced changes in O2 concentration dependent on the relative position of the stimulating and working electrodes, but none of the responses resembled that seen in the caudate slice. Thus, while measurements in brain slices show O2 consumption as a result of stimulated neuronal activity, an apparent elevation of local cerebral blood flow during and after stimulation dominate the in vivo response.

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