scholarly journals Direct commissural connections to the basket cells of the hippocampal dentate gyrus: anatomical evidence for feed-forward inhibition

1984 ◽  
Vol 13 (2) ◽  
pp. 215-225 ◽  
Author(s):  
L�szl� Seress ◽  
Charles E. Ribak
Keyword(s):  
Dentate Gyrus ◽  
Hippocampal Dentate Gyrus ◽  
Feed Forward ◽  
Basket Cells ◽  
Anatomical Evidence ◽  
Feed Forward Inhibition ◽  
Commissural Connections

scholarly journals Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus

2013 ◽  
Vol 110 (22) ◽  
pp. 9106-9111 ◽  
Author(s):  
Y. Li ◽  
F. J. Stam ◽  
J. B. Aimone ◽  
M. Goulding ◽  
E. M. Callaway ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Molecular Layer ◽  
Perforant Path ◽  
Feed Forward ◽  
Feed Forward Inhibition

Field potential evidence for long-term potentiation of feed-forward inhibition in the rat dentate gyrus

1987 ◽  
Vol 401 (1) ◽  
pp. 87-94 ◽  
Author(s):  
Edward W. Kairiss ◽  
Wickliffe C. Abraham ◽  
David K. Bilkey ◽  
Graham V. Goddard
Keyword(s):  
Dentate Gyrus ◽  
Field Potential ◽  
Long Term Potentiation ◽  
Feed Forward ◽  
Term Potentiation ◽  
Feed Forward Inhibition

Malfunctional Reorganization in the Developing Limbo-Prefrontal System in Animals: Implications for Human Psychoses?

2001 ◽  
Vol 12 (1) ◽  
pp. 8-14
Author(s):  
Gertraud Teuchert-Noodt ◽  
Ralf R. Dawirs
Keyword(s):  
Prefrontal Cortex ◽  
Mental Disorders ◽  
Dentate Gyrus ◽  
Cognitive Functions ◽  
Experimental Approach ◽  
Regulatory Mechanisms ◽  
Hippocampal Dentate Gyrus ◽  
Non Invasive ◽  
Invasive Method ◽  
Activity Dependent

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.

Increase in extracellular dopamine levels during clozapine-induced potentiation in the hippocampal dentate gyrus of chronically prepared rabbits

2008 ◽  
Vol 86 (5) ◽  
pp. 249-256 ◽  
Author(s):  
Takashi Kubota ◽  
Itsuki Jibiki ◽  
Akira Ishikawa ◽  
Tomomi Kawamura ◽  
Sonoko Kurokawa ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Nmda Receptor ◽  
Dentate Gyrus ◽  
Negative Symptoms ◽  
Clinical Effect ◽  
Perforant Path ◽  
Hippocampal Dentate Gyrus ◽  
Extracellular Dopamine ◽  
Stimulation Of ◽  
Synaptic Responses

We previously found that 20 mg/kg clozapine i.p. potentiated the excitatory synaptic responses elicited in the dentate gyrus by single electrical stimulation of the perforant path in chronically prepared rabbits. We called this phenomenon clozapine-induced potentiation and proved that it was an NMDA receptor-mediated event. This potentiation is presumably related to clozapine’s clinical effect on negative symptoms and cognitive dysfunctions in schizophrenia. In the present study, to investigate the mechanisms underlying clozapine-induced potentiation, we examined whether extracellular dopamine and 5-HT levels changed during the potentiation by using a microdialysis technique in the dentate gyrus. The extracellular concentrations of dopamine and 5-HT levels were measured every 5 min during all experiments. Extracellular 5-HT levels did not change, but dopamine levels eventually increased significantly during clozapine-induced potentiation. The increase in the dopamine levels occurred almost simultaneously with the induction of clozapine-induced potentiation. These results suggest that clozapine-induced potentiation is at least partly attributable to a dopamine-mediated potentiation of excitatory synaptic transmission. The present study implies that such phenomena occur also in the perforant path–dentate gyrus pathway.

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