scholarly journals Postnatal development of the light and electron microscopic features of basket cells in the hippocampal dentate gyrus of the rat

1990 ◽  
Vol 181 (6) ◽  
Author(s):  
L�szl� Seress ◽  
CharlesE. Ribak
Keyword(s):  
Dentate Gyrus ◽  
Postnatal Development ◽  
Hippocampal Dentate Gyrus ◽  
Electron Microscopic ◽  
Basket Cells ◽  
Microscopic Features

scholarly journals Impaired postnatal development of hippocampal dentate gyrus in Sp4 null mutant mice

2007 ◽  
Vol 6 (3) ◽  
pp. 269-276 ◽  
Author(s):  
X. Zhou ◽  
Y. Qyang ◽  
J. R. Kelsoe ◽  
E. Masliah ◽  
M. A. Geyer
Keyword(s):  
Dentate Gyrus ◽  
Postnatal Development ◽  
Mutant Mice ◽  
Null Mutant ◽  
Hippocampal Dentate Gyrus ◽  
Null Mutant Mice

Fine Structural Classification of Chromophobe Adenomas of the Human Pituitary Gland

1975 ◽  
Vol 33 ◽  
pp. 378-379
Author(s):  
K. Kovacs ◽  
E. Horvath
Keyword(s):  
Pituitary Adenomas ◽  
Secretory Activity ◽  
Microscopic Investigation ◽  
Uranyl Acetate ◽  
Electron Microscopic Investigation ◽  
Electron Microscopic ◽  
Human Pituitary ◽  
Cytoplasmic Staining ◽  
Human Pituitary Gland ◽  
Microscopic Features

Chromophobe pituitary adenomas arise from adenohypophysial cells and fail to exhibit cytoplasmic staining with conventional acid or basic dyes by light microscopy. The aim of the present work was to study the electron microscopic features of these tumors, to separate them into distinct entities and to correlate their fine structural appearances with secretory activity.Among 48 surgically removed various pituitary adenomas 30 tumors were found which, based on the tinctorial characteristics of the cytoplasm, corresponded to chromophobe adenomas. For electron microscopic investigation pieces of these tumors were fixed in 2.5 per cent glutaraldehyde in Sorensen's buffer, post fixed in 1 per cent osmium tetroxide in Millonig's buffer, dehydrated in graded ethanol and embedded in Epon 812. Ultrathin sections were stained with uranyl acetate and lead citrate.By electron microscopy it was possible to separate chromophobe adenomas into 3 distinct entities: 1) adenomas consisting of sparsely granulated growth hormone cells (7 cases).

Ultrastructural Study of Apocrine Differentiation in Human Mammary Carcinoma: Correlation of Granule Content With Sex Steroid Binding

1980 ◽  
Vol 38 ◽  
pp. 742-743
Author(s):  
S. E. Levine ◽  
A. D. Brinkhous ◽  
K. S. McCarty ◽  
J. A. Mossier ◽  
K.S. McCarty
Keyword(s):  
Ultrastructural Study ◽  
Ductal Carcinoma ◽  
Apocrine Carcinoma ◽  
Electron Microscopic ◽  
Granular Eosinophilic Cytoplasm ◽  
Eosinophilic Cytoplasm ◽  
Apocrine Differentiation ◽  
Microscopic Features ◽  
Membrane Bound ◽  
Epithelial Lesions

A variant of ductal carcinoma of the human breast which has been designated apocrine carcinoma has distinctive light and electron microscopic features. Such tumors comprise approximately 0.5% of breast carcinomas. Abundant cytoplasmic membrane bound vesicles (400-600 nm) with dense homogeneous osmophilic cores characterize these tumors. These granules are also seen in apocrine metaplastic breast epithelial lesions1 and appear to be responsible for the finely granular eosinophilic cytoplasm observed by light microscopy. A high content of intermediate affinity non-saturable 4S progesteroneestrogen binding protein (PEBP) in apocrine carcinoma has been reported.2 The present ultrastructural study evaluates the presence of apocrine granules in infiltrating ductal carcinoma (NOS) to determine if a correlation exists between apocrine granule content and the quantity of PEBP present.

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