Auditory suppression of the postsynaptic inhibition in photically evoked responses

V. G. Skrebitskii

doi:10.1007/bf01124390

Postsynaptic inhibition in photically evoked responses and its change during distraction of the animals

Brain Research ◽

10.1016/0006-8993(69)90126-7 ◽

1969 ◽

Vol 14 (2) ◽

pp. 510-512 ◽

Cited By ~ 5

Author(s):

V.G. Skrebitsky

Keyword(s):

Evoked Responses ◽

Postsynaptic Inhibition

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Pre- and postsynaptic inhibition by nociceptin in guinea pig small intestinal myenteric plexus in vitro

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.2001.281.1.g237 ◽

2001 ◽

Vol 281 (1) ◽

pp. G237-G246 ◽

Cited By ~ 13

Author(s):

Sumei Liu ◽

Hong-Zhen Hu ◽

Jun Ren ◽

Chuanyun Gao ◽

Na Gao ◽

...

Keyword(s):

Membrane Potential ◽

Guinea Pig ◽

Myenteric Plexus ◽

Inhibitory Action ◽

Partial Agonist ◽

Evoked Responses ◽

Postsynaptic Inhibition ◽

Synaptic Excitation ◽

Small Intestinal

Actions of nociceptin on electrical and synaptic behavior of morphologically and neurochemically identified neurons in the guinea pig duodenal myenteric plexus were studied with conventional techniques. Nociceptin hyperpolarized the membrane potential in 104 of 121 AH-type and 28 of 51 S-type neurons with an EC50 of 11.9 ± 1.2 nM. Increased K+ conductance accounted for the hyperpolarizing responses that were blocked by pertussis toxin and unaffected by naloxone. The selective opioid receptor-like (ORL)1 receptor antagonist [Phe1-psi(CH2-NH)-Gly2]nociceptin(1–13)-NH2suppressed the nociceptin-evoked responses while behaving like a partial agonist. The nonselective ORL1 antagonist naloxone benzoylhydrazone competitively suppressed nociceptin actions with a pA2 value of 5.8. Nociceptin acted at presynaptic inhibitory receptors to suppress fast excitatory nicotinic postsynaptic potentials in 25 of 30 neurons (EC50 = 22.5 ± 4.4 nM) and slow synaptic excitation in 38 of 45 neurons (EC50 = 15.1 ± 1.6 nM). Presynaptic inhibitory action of nociceptin was unaffected by naloxone and was antagonized by [Phe1-psi(CH2-NH)-Gly2]nociceptin(1–13)-NH2or naloxone benzoylhydrazone. The results suggest that nociceptin acts both pre- and postsynaptically by activating an ORL1receptor that is distinct from typical naloxone-sensitive opioid receptors.

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Alterations of Interhippocampal Impulses in Man during Natural Sleep and Distraction

Perceptual and Motor Skills ◽

10.2466/pms.1965.21.2.591 ◽

1965 ◽

Vol 21 (2) ◽

pp. 591-594

Author(s):

R. Guerrero-Figueroa ◽

Robert G. Heath

Keyword(s):

Eye Movements ◽

Reticular Formation ◽

Slow Wave ◽

Mesencephalic Reticular Formation ◽

Evoked Responses ◽

Postsynaptic Inhibition ◽

Eeg Activity ◽

Natural Sleep ◽

Marked Diminution ◽

Mathematics Problem

Interhippocampal evoked responses (IHR) were studied in two fully conscious men during wakefulness (w), natural sleep associated with slow wave electroencephalographic (EEG) activity (SS), sleep associated with rapid EEG activity (RS) and with rapid eye movements (REM), or both, and during distraction or attention. Striking incremental changes in amplitude of pre- and postsynaptic components of the IHR appeared during SS, whereas there was marked diminution in the amplitude of all components of the IHR during RS and REM, and while Ss solved a mathematics problem. It was suggested that hippocampal pre- and postsynaptic inhibition during attention and dreaming is dependent upon inhibitory influences from mesencephalic reticular formation.

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Averaged Evoked Responses and Loudness: Analysis of Response Estimates

Journal of Speech and Hearing Research ◽

10.1044/jshr.1102.334 ◽

1968 ◽

Vol 11 (2) ◽

pp. 334-342 ◽

Cited By ~ 8

Author(s):

Gretchen B. Henry ◽

Donald C. Teas

Keyword(s):

Noise Burst ◽

Response Magnitude ◽

Evoked Responses ◽

Maximum Estimate

Averaged evoked responses to noise burst signals at six sensation levels were obtained in three experimental contexts and compared on the basis of response magnitude. No significant effects were found related to context; systematic differences were found, however, within the ensemble of responses making up the average. These differences suggest that the maximum estimate of response magnitude may be contained in the first few responses to a series of stimuli.

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