High liver lipoprotein lipase activity in hyperlipemic developing rats from undernourished pregnant mothers

1988 ◽  
Vol 8 (4) ◽  
pp. 309-314 ◽  
Author(s):  
D. López-Tejero ◽  
M. Llobera ◽  
E. Herrera
Keyword(s):  
Lipoprotein Lipase ◽  
Normal Control ◽  
Rat Liver ◽  
Lipase Activity ◽  
Hepatic Uptake ◽  
Lipoprotein Lipase Activity ◽  
Newborn Rat ◽  
Potential Relationship ◽  
High Liver ◽  
Pregnant Mothers

To study the potential relationship between circulating triacylglycerol (TAG) levels and lipoprotein lipase (LPL) activity in the newborn rat liver, pups from undernourished or normal control mothers were nursed by normal dams, and studied at 0, 1, 15 or 30 days of age. Plasma TAG levels and liver TAG concentration increased more in pups from undernourished mothers than they did in controls. At birth, liver LPL activity was similarly high in both groups but, whereas in controls it decreased progressively after birth, in pups from undernourished mothers it remained stable until 15 days of age. Results suggest that the hypertriglyceridemia present in pups from undernourished mothers may be responsible for the sustained high LPL activity in their liver which may enhance the hepatic uptake of circulating TAG.

Characterization of Lipoprotein Lipase Activity in the Newborn Rat Liver

Neonatology ◽  
1987 ◽  
Vol 51 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Manuel Reina ◽  
Senén Vilaró ◽  
Ignasi Ramirez ◽  
Miquel Llobera
Keyword(s):  
Lipoprotein Lipase ◽  
Rat Liver ◽  
Lipase Activity ◽  
Lipoprotein Lipase Activity ◽  
Newborn Rat

Starvation enhances lipoprotein lipase activity in the liver of the newborn rat

1985 ◽  
Vol 833 (2) ◽  
pp. 217-222 ◽  
Author(s):  
Daniel R. Grinberg ◽  
Ignasi Ramirez ◽  
Senén Vilaró ◽  
Manuel Reina ◽  
Miquel Llobera ◽  
...  
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Lipoprotein Lipase Activity ◽  
Newborn Rat

scholarly journals Heparin-binding apoproteins. Effects on lipoprotein lipase and hepatic uptake of remnants

1986 ◽  
Vol 233 (3) ◽  
pp. 909-912 ◽  
Author(s):  
J Borensztajn ◽  
T J Kotlar ◽  
C A Matza
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Hepatic Uptake ◽  
Heparin Binding ◽  
Lipoprotein Lipase Activity ◽  
Glycoprotein I ◽  
Apoprotein E ◽  
Beta 2 ◽  
No Activation

Apoprotein-free heparin-binding and non-binding chylomicrons were used as substrates to test the effects on lipoprotein lipase activity of (a) chylomicron protein I; (b) the mixture of proteins I, II and apoprotein E and (c) human beta 2-glycoprotein I. No activation of the enzyme was observed with any of those apoproteins. When rats were injected simultaneously with [3H]cholesterol-labelled heparin-binding chylomicrons (containing proteins I and II) and [14C]cholesterol-labelled non-binding chylomicrons, no differences were detected between the rates of removal from circulation of those two types of particles. Clearance of chylomicrons from circulation was accompanied by the incorporation of 3H and 14C labels into the livers at similar rates. It is concluded that proteins I, II and apoprotein E have no effect on the degradation of chylomicrons by lipoprotein lipase and that the hepatic recognition of remnants does not appear to be affected by proteins I and II.

scholarly journals Lipoprotein lipase activity in neonatal-rat liver cell types

1989 ◽  
Vol 259 (1) ◽  
pp. 159-166 ◽  
Author(s):  
F Burgaya ◽  
J Peinado ◽  
S Vilaró ◽  
M Llobera ◽  
I Ramírez
Keyword(s):  
Lipoprotein Lipase ◽  
Rat Liver ◽  
Lipase Activity ◽  
Cell Types ◽  
Total Activity ◽  
Time Dependent ◽  
Neonatal Rat ◽  
Lipoprotein Lipase Activity ◽  
Adult Rats ◽  
Fraction I

The lipoprotein lipase activity in the liver of neonatal (1 day old) rats was about 3 times that in the liver of adult rats. Perfusion of the neonatal liver with collagenase decreased the tissue-associated activity by 77%. When neonatal-rat liver cells were dispersed, hepatocyte-enriched (fraction I) and haemopoietic-cell-enriched (fraction II) populations were obtained. The lipoprotein lipase activity in fraction I was 7 times that in fraction II. On the basis of those activities and the proportion of both cell types in either fraction, it was estimated that hepatocytes contained most, if not all, the lipoprotein lipase activity detected in collagenase-perfused neonatal-rat livers. From those calculations it was also concluded that haemopoietic cells did not contain lipoprotein lipase activity. When the hepatocyte-enriched cell population was incubated at 25 degrees C for up to 3 h, a slow but progressive release of enzyme activity to the incubation medium was found. However, the total activity (cells + medium) did not significantly change through the incubation period. Cycloheximide produced a time-dependent decrease in the cell-associated activity. Heparin increased the amount of lipoprotein lipase activity released to the medium. Because the cell-associated activity was unchanged, heparin also produced a time-dependent increase in the total activity. In those cells incubated with heparin, cycloheximide did not affect the initial release of lipoprotein lipase activity to the medium, but blocked further release. The cell-associated activity was also decreased by the presence of cycloheximide in those cells. It is concluded that neonatal-rat hepatocytes synthesize active lipoprotein lipase.

scholarly journals Retention of glucose by N-linked oligosaccharide chains impedes expression of lipoprotein lipase activity: effect of castanospermine.

1992 ◽  
Vol 33 (9) ◽  
pp. 1343-1349
Author(s):  
H Masuno ◽  
EJ Blanchette-Mackie ◽  
CJ Schultz ◽  
AE Spaeth ◽  
RO Scow ◽  
...  
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Lipoprotein Lipase Activity ◽  
Activity Effect
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