Sugar absorption by small bowel biopsy samples from patients with primary lactase deficiency and with adult celiac disease

1976 ◽  
Vol 21 (11) ◽  
pp. 946-952 ◽  
Author(s):  
I. T. Beck ◽  
P. K. Dinda ◽  
L. R. Costa ◽  
M. Beck
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Lactase Deficiency ◽  
Small Bowel Biopsy ◽  
Sugar Absorption ◽  
Adult Celiac Disease

scholarly journals Serological Testing in Screening for Adult Celiac Disease

1999 ◽  
Vol 13 (3) ◽  
pp. 265-269 ◽  
Author(s):  
Helen Rachel Gillett ◽  
Hugh James Freeman
Keyword(s):  
Celiac Disease ◽  
High Risk ◽  
Small Bowel ◽  
Clinical Use ◽  
Serological Testing ◽  
First Line ◽  
Small Bowel Biopsy ◽  
Atypical Symptoms ◽  
Adult Celiac Disease ◽  
Antibody Tests

Assays for celiac-related antibodies are becoming widely available, and the present review aims to clarify the use of these investigations in the diagnosis of, management of and screening for adult celiac disease. The sensitivities and specificities of various antibody tests are discussed, along with their clinical use as an adjunct to small bowel biopsy, and as a first-line investigation for patients with atypical symptoms of celiac disease or patients at high risk of developing sprue.

scholarly journals Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis

2000 ◽  
Vol 14 (11) ◽  
pp. 919-921 ◽  
Author(s):  
Helen Rachel Gillett ◽  
Hugh James Freeman
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Tissue Transglutaminase ◽  
Immunoglobulin A ◽  
Collagenous Colitis ◽  
Lymphocytic Colitis ◽  
Small Bowel Biopsy ◽  
Major Antigen ◽  
Immunofluorescent Technique ◽  
Endomysium Antibody

Both collagenous and lymphocytic colitis have been described in patients with celiac disease, suggesting an association between the conditions. Over the past few years, the availability, sensitivity and specificity of serological markers for celiac disease have improved - the most recent advancement being the description of tissue transglutaminase as the major antigen for endomysium antibody. A quantitative ELISA was used to measure titres of immunoglobulin A (IgA) antibody to tissue transglutaminase (tTG) along with an immunofluorescent technique for IgA endomysium antibody (EmA) in 15 patients with lymphocytic colitis and eight with collagenous colitis to determine whether celiac disease latency could be detected. One patient with lymphocytic colitis demonstrated both elevated titres of tTG antibody and positive EmA, and small bowel biopsy confirmed celiac disease. One patient with collagenous colitis had a slightly elevated titre of tTG antibody with a negative EmA, and results of a small bowel biopsy were normal. Three other patients with lymphocytic colitis were already treated for previously diagnosed celiac disease. The prevalence of celiac disease occurring in lymphocytic colitis was found to be 27%, but no cases of celiac disease in association with collagenous colitis were found.

Celiac Disease and Sensitization to Wheat, Rye, and Barley: Should We Be Concerned?

2020 ◽  
pp. 1-7
Author(s):  
Camila Marques de Valois Lanzarin ◽  
Natalia de Oliveira e Silva ◽  
Maissara Obara Venturieri ◽  
Dirceu Solé ◽  
Ricardo Palmero Oliveira ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Case Reports ◽  
Serum Levels ◽  
Specific Ige ◽  
Age At Diagnosis ◽  
Gluten Free ◽  
Small Bowel Biopsy ◽  
History Of ◽  
Ige Mediated

<b><i>Background:</i></b> Concomitance of celiac disease (CD) and IgE-mediated wheat allergy is described in some case reports. The objective was to evaluate the frequency of sensitization to wheat, rye, barley, and malt in children and adolescents with CD. <b><i>Methods:</i></b> Measurement of serum levels of specific IgE to wheat, rye, barley, and malt (ImmunoCAP; sensitization IgE ≥0.35 kUA/L) in CD patients followed in specialized clinics to verify allergy history, general characteristics, small bowel biopsy characteristics, compliance with gluten-free diet (GFD), and occurrence of symptoms in case of noncompliance. <b><i>Results:</i></b> We evaluated 74 patients; the median of age and age at diagnosis of CD were 8.6 years (5.0–12.8) and 3.6 years (1.6–7.0), respectively. Median time of GFD was 3.5 years (1.4–5.8). History of asthma occurred in 17.3% of subjects, allergic rhinitis in 13.5%, and AD in 5.4%. Frequency of sensitization was 4% for wheat, 10.8% for rye, 5.4% for barley, and 2.7% for malt. There was no association between wheat sensitization and age at diagnosis, time of GFD, small bowel biopsy characteristics, allergy history, and gluten consumption. There was no relationship between sensitization to wheat and occurrence of immediate symptoms when not complying with GFD. <b><i>Conclusion:</i></b> In conclusion, the frequency of sensitization to wheat, rye, barley, and malt in CD patients was 4, 10.8, 5.4, and 2.7%, respectively. Therefore, to ensure that cutaneous and respiratory contact with wheat is safe, we advise patients with CD to investigate their sensitivity to wheat, rye, and barley because not all patients with CD are allergic to these cereals.

Radiographic indicants of adult celiac disease assessed by double-contrast small bowel enteroclysis

1992 ◽  
Vol 15 (2) ◽  
pp. 157-162 ◽  
Author(s):  
Francesco La Seta ◽  
Giuseppe Salerno ◽  
Antonio Buccellato ◽  
Fabio Tine' ◽  
Grazia Furnari
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Double Contrast ◽  
Adult Celiac Disease

P0432 CAN TTG REPLACE SMALL BOWEL BIOPSY TO DIAGNOSE CELIAC DISEASE IN SELECT PEDIATRIC POPULATIONS?

2004 ◽  
Vol 39 (Supplement 1) ◽  
pp. S220
Author(s):  
Collin C. Barker ◽  
Gareth Jevon ◽  
Cheng-Han Lee ◽  
Thomas Mock
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Small Bowel Biopsy ◽  
Pediatric Populations

Symptomatic small bowel intussusception: a surgical opportunity to diagnose adult celiac disease?

2004 ◽  
Vol 59 (1) ◽  
pp. 161-162 ◽  
Author(s):  
David S. Sanders ◽  
Iman A.F. Azmy ◽  
San C. Kong ◽  
Frederick K.T. Lee
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Adult Celiac Disease ◽  
Small Bowel Intussusception

scholarly journals Comparison of IgA Endomysium Antibody and IgA Tissue Transglutaminase Antibody in Celiac Disease

2000 ◽  
Vol 14 (8) ◽  
pp. 668-671 ◽  
Author(s):  
Helen R Gillett ◽  
Hugh J Freeman
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Disease Control ◽  
Predictive Value ◽  
Tissue Transglutaminase ◽  
Control Group ◽  
Human Umbilical Cord ◽  
Predictive Values ◽  
Small Bowel Biopsy ◽  
Control Subjects

The antigen for immunoglobulin (Ig)Aendomysium antibody (EmA), a sensitive and specific serological marker for celiac disease, has recently been described as tissue transglutaminase (tTG). The aim of this study was to compare the assays used to measure IgAEmAand IgA tTG antibody in patients with celiac disease and disease control subjects. Sera from 21 patients with untreated celiac disease, 48 patients with treated celiac disease and 128 disease control subjects were tested both for IgA EmA with the use of indirect immunofluorescence against human umbilical cord and for IgA tTG antibody with the use of ELISA. Titres of IgA tTG antibody were significantly higher in both the untreated and treated celiac groups than in the disease control group. Titres in the treated group were, however, significantly lower than in the untreated group. A reference range was calculated to include 99.8% of the disease control group in whom small bowel biopsy showed no evidence of celiac disease. One patient from the disease control group with raised IgA tTG antibody titres and positive IgA EmA was found to have celiac disease on small bowel biopsy. The sensitivity, specificity, and positive and negative predictive values of the IgA EmA assay were all 100%. The sensitivity of the IgA tTG antibody assay was 95%, specificity 100%, positive predictive value 100% and negative predictive value 97.7%. An ELISA used to measure IgA tTG antibody is an excellent tool to screen for celiac disease and may prove useful for monitoring response to treatment.

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