Unique approach for calculation of first-order absorption rate constants from blood or urine data

1980 ◽  
Vol 8 (2) ◽  
pp. 203-214 ◽  
Author(s):  
C. Pidgeon ◽  
W. H. Pitlick
Keyword(s):  
Rate Constants ◽  
Absorption Rate ◽  
First Order ◽  
Absorption Rate Constants ◽  
Unique Approach

Computational Prediction of Oral Drug Absorption Based on Absorption Rate Constants in Humans

2006 ◽  
Vol 49 (12) ◽  
pp. 3674-3681 ◽  
Author(s):  
Johanna Linnankoski ◽  
Johanna M Mäkelä ◽  
Veli-Pekka Ranta ◽  
Arto Urtti ◽  
Marjo Yliperttula
Keyword(s):  
Drug Absorption ◽  
Rate Constants ◽  
Absorption Rate ◽  
Computational Prediction ◽  
Oral Drug ◽  
Oral Drug Absorption ◽  
Absorption Rate Constants

scholarly journals Effects of Last Dosing Time on Population Pharmacokinetic Analysis of Tacrolimus Performed using Extracted Data from Electronic Health Records

2021 ◽  
Author(s):  
Michael L. Williams ◽  
Hannah L. Weeks ◽  
Cole Beck ◽  
Leena Choi
Keyword(s):  
Language Processing ◽  
Rate Constants ◽  
Absorption Rate ◽  
Processing System ◽  
Population Level ◽  
Pharmacokinetic Analysis ◽  
Population Pharmacokinetic ◽  
Parameter Estimates ◽  
Real World Data ◽  
Absorption Rate Constants

AbstractA tacrolimus population pharmacokinetic (PK) study with 440 subjects was performed using real world data extracted from electronic heath records (EHRs) to identify patient factors affecting variability in tacrolimus PK parameters. Using last-dose times extracted by our own natural language processing system, medExtractR, we assessed the effects of incorporating last-dose times in the data on tacrolimus PK parameter estimates. The estimates of population level PK parameters were Cl = 24.9 L/h [23.5, 26.3] and V = 6310 L [5461, 7159]. There was no appreciable difference in parameters estimates with vs. without last-dose time incorporated in the data. We also investigated the effects of absorption rate constants that are often fixed at a published value in tacrolimus population PK analysis. Our sensitivity analysis revealed little difference between parameters estimated assuming a range of absorption rate constants.

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