Interrelationships among hydrologic-budget components of a northern Wisconsin seepage lake and implications for acid-deposition modeling

Dogwood anthracnose, caused by Discula destructiva (1), is another new catastrophic tree disease that has ravaged natural populations of the flowering dogwood (Cornus florida) in the Appalachians over the past 15 years, and the epidemic is prognosticated to continue (2). An estimated 9.5 million acres have been affected, primarily in the Appalachian Mountains, from VA southwards, alone, and an estimated 50% of all dogwoods in PA have been killed. Since acid deposition has been linked experimentally with disease induction, and since the disease incidence and severity are more pronounced at higher elevations where lower pH precipitation events occur, we investigated the effect of acidic foliar sprays on moiphologic changes in the foliar cuticle and trichomes (3), the initial sites of infection and foci of Discula sporulation.

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Identifying Sources of Sulfate Aerosols Reaching Whiteface Mountain, NY

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100117546 ◽

1985 ◽

Vol 43 ◽

pp. 98-101

Author(s):

James S. Webber

Keyword(s):

Trace Metals ◽

Acid Deposition ◽

Surface Waters ◽

Dry Deposition ◽

Coal Combustion ◽

Public Awareness ◽

Sulfate Aerosols ◽

Wet And Dry Deposition ◽

Whiteface Mountain ◽

Toxic Trace Metals

INTRODUCTION“Acid rain” and “acid deposition” are terms no longer confined to the lexicon of atmospheric scientists and 1imnologists. Public awareness of and concern over this phenomenon, particularly as it affects acid-sensitive regions of North America, have increased dramatically in the last five years. Temperate ecosystems are suffering from decreased pH caused by acid deposition. Human health may be directly affected by respirable sulfates and by the increased solubility of toxic trace metals in acidified waters. Even man's monuments are deteriorating as airborne acids etch metal and stone features.Sulfates account for about two thirds of airborne acids with wet and dry deposition contributing equally to acids reaching surface waters or ground. The industrial Midwest is widely assumed to be the source of most sulfates reaching the acid-sensitive Northeast since S02 emitted as a byproduct of coal combustion in the Midwest dwarfs S02 emitted from all sources in the Northeast.

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Two-Compartment Capsular Devices for Oral Pulsatile Delivery 3D-Printed by Fused Deposition Modeling

10.26226/morressier.57d6b2b6d462b8028d88d9d6 ◽

2016 ◽

Author(s):

Federica Casati

Keyword(s):

Fused Deposition Modeling ◽

Fused Deposition ◽

Deposition Modeling ◽

3D Printed ◽

Pulsatile Delivery

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Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

10.26434/chemrxiv.5851950.v1 ◽

2018 ◽

Cited By ~ 1

Author(s):

Michael A. Luzuriaga ◽

Danielle R. Berry ◽

John C. Reagan ◽

Ronald A. Smaldone ◽

Jeremiah J. Gassensmith

Keyword(s):

Drug Delivery ◽

3D Printing ◽

Transdermal Drug Delivery ◽

Fused Deposition Modeling ◽

Fused Deposition ◽

Modeling Software ◽

Deposition Modeling ◽

3D Printed ◽

Microfabrication Technique ◽

Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

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