Excitation of cat spinal cord dorsal column fibers during stimulation of different fiber groups of cutaneous and somatic nerves

1993 ◽  
Vol 24 (5) ◽  
pp. 417-424
Author(s):  
V. L. Shaposhnikov
Keyword(s):  
Spinal Cord ◽  
Dorsal Column ◽  
Spinal Cord Dorsal ◽  
Stimulation Of

scholarly journals Leukoencephalopathy with brainstem and spinal cord involvement and high brain lactate: report of three brazilian patients

2007 ◽  
Vol 65 (2b) ◽  
pp. 506-511 ◽  
Author(s):  
Daniel Gurgel Fernandes Távora ◽  
Mauro Nakayama ◽  
Rômulo Lopes Gama ◽  
Thereza Cristina de Lara Alvim ◽  
Dalton Portugal ◽  
...  
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Magnetic Resonance ◽  
Autosomal Recessive Disorder ◽  
Dorsal Column ◽  
Resonance Spectroscopy ◽  
Motor Neuropathy ◽  
Spinal Cord Involvement ◽  
Spinal Cord Dorsal ◽  
Magnetic Resonance Imaging Mri

A novel leukoencephalopathy was recently identified based on magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (¹H-MRS) findings. Leukoencephalopathy with brainstem and spinal cord involvement and high lactate (LBSL) is an autosomal recessive disorder characterized by early onset of symptoms and slowly progressive cerebellar, pyramidal and spinal cord dorsal column dysfunction. MRI and ¹H-MRS typically show abnormalities within cerebral and cerebellar white matter, a characteristic involvement of brainstem and spinal cord tracts and elevated lactate in the abnormal white matter. We present three cases with characteristic clinical and neuroimaging findings of this disorder. Some additional unique findings of our patients are discussed, like distal motor neuropathy and elevated creatine kinase in the serum.

scholarly journals Spinal cord α-synuclein deposition associated with myoclonus in patients with MSA-C

Neurology ◽  
2019 ◽  
Vol 93 (7) ◽  
pp. 302-309 ◽  
Author(s):  
Jaeho Hwang ◽  
Anna M. Bank ◽  
Farzad Mortazavi ◽  
Derek H. Oakley ◽  
Matthew P. Frosch ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Massachusetts General Hospital ◽  
Multiple Linear Regression Model ◽  
Dorsal Column ◽  
Objective Lens ◽  
Mixed Effect ◽  
Corticospinal Tracts ◽  
Spinal Cord Dorsal ◽  
Left And Right ◽  
Imagej Software

ObjectiveTo test the hypothesis that myoclonus in patients with multiple system atrophy with predominant cerebellar ataxia (MSA-C) is associated with a heavier burden of α-synuclein deposition in the motor regions of the spinal cord, we compared the degree of α-synuclein deposition in spinal cords of 3 patients with MSA-C with myoclonus and 3 without myoclonus.MethodsAll human tissue was obtained by the Massachusetts General Hospital Department of Pathology with support from and according to neuropathology guidelines of the Massachusetts Alzheimer's Disease Research Center. Tissue was stained with Luxol fast blue and hematoxylin & eosin for morphologic evaluation, and with a mouse monoclonal antibody to α-synuclein and Vectastain DAB kit. Images of the spinal cord sections were digitized using a 10× objective lens. Grayscale versions of these images were transferred to ImageJ software for quantitative analysis of 8 different regions of interest (ROIs) in the spinal cord: dorsal column, anterior white column, left and right dorsal horns, left and right anterior horns, and left and right lateral corticospinal tracts. A mixed-effect, multiple linear regression model was constructed to determine if patients with and without myoclonus had significantly different distributions of α-synuclein deposition across the various ROIs.ResultsPatients with myoclonus had more α-synuclein in the anterior horns (p < 0.001) and lateral corticospinal tracts (p = 0.02) than those without myoclonus.ConclusionsIn MSA-C, myoclonus appears to be associated with a higher burden of α-synuclein deposition within spinal cord motor regions. Future studies with more patients will be needed to confirm these findings.

Delayed Glial Cell Death Following Wallerian Degeneration in White Matter Tracts after Spinal Cord Dorsal Column Cordotomy in Adult Rats

2001 ◽  
Vol 168 (2) ◽  
pp. 213-224 ◽  
Author(s):  
Patricia Warden ◽  
Norman I. Bamber ◽  
Huaying Li ◽  
Andrew Esposito ◽  
Kaashif A. Ahmad ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cell Death ◽  
White Matter ◽  
Glial Cell ◽  
Wallerian Degeneration ◽  
Dorsal Column ◽  
Adult Rats ◽  
White Matter Tracts ◽  
Spinal Cord Dorsal

Evoked Compound Action Potentials Reveal Spinal Cord Dorsal Column Neuroanatomy

2019 ◽  
Vol 23 (1) ◽  
pp. 82-95 ◽  
Author(s):  
John L. Parker ◽  
Milan Obradovic ◽  
Nastaran Hesam Shariati ◽  
Robert B. Gorman ◽  
Dean M. Karantonis ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Action Potentials ◽  
Dorsal Column ◽  
Compound Action Potentials ◽  
Spinal Cord Dorsal ◽  
Compound Action

Percutaneous epidural stimulation of the spinal cord for relief of pain

1978 ◽  
Vol 48 (3) ◽  
pp. 323-328 ◽  
Author(s):  
Bruno J. Urban ◽  
Blaine S. Nashold
Keyword(s):  
Spinal Cord ◽  
Dorsal Column ◽  
Long Term Results ◽  
Percutaneous Technique ◽  
Intractable Pain ◽  
Epidural Stimulation ◽  
Content Type ◽  
Major Operation ◽  
Stimulation Of

✓ Percutaneous epidural stimulation of the spinal cord was carried out in 20 patients with intractable pain. The procedure proved simple, and no major complications were encountered. The long-term results were comparable to the results obtained after a dorsal column stimulator implant by laminectomy. The percutaneous technique allowed extended trial stimulation without committing the patient to a major operation. Those patients in whom stimulation did not alleviate pain could be identified during a 2-week observation period, and the system could be removed easily. Seven patients were placed on chronic autostimulation and only one of those failed to experience continuing pain relief throughout the follow-up time of up to 2 years. It is concluded that percutaneous epidural stimulation constitutes a valid alternative to dorsal column stimulator implantation.

scholarly journals Second-order spinal cord pathway contributes to cortical responses after long recoveries from dorsal column injury in squirrel monkeys

2018 ◽  
Vol 115 (16) ◽  
pp. 4258-4263 ◽  
Author(s):  
Chia-Chi Liao ◽  
Jamie L. Reed ◽  
Hui-Xin Qi ◽  
Eva K. Sawyer ◽  
Jon H. Kaas
Keyword(s):  
Spinal Cord ◽  
Dorsal Column ◽  
Squirrel Monkeys ◽  
Second Order ◽  
Spinal Cord Neurons ◽  
Somatotopic Organization ◽  
Recovery Times ◽  
Spinal Cord Dorsal ◽  
Hand Region ◽  
Area 3B

Months after the occurrence of spinal cord dorsal column lesions (DCLs) at the cervical level, neural responses in the hand representation of somatosensory area 3b hand cortex recover, along with hand use. To examine whether the second-order spinal cord pathway contributes to this functional recovery, we injected cholera toxin subunit B (CTB) into the hand representation in the cuneate nucleus (Cu) to label the spinal cord neurons, and related results to cortical reactivation in four squirrel monkeys (Saimiri boliviensis) at least 7 months after DCL. In two monkeys with complete DCLs, few CTB-labeled neurons were present below the lesion, and few neurons in the affected hand region in area 3b responded to touch on the hand. In two other cases with large but incomplete DCLs, CTB-labeled neurons were abundant below the lesion, and the area 3b hand cortex responded well to tactile stimulation in a roughly somatotopic organization. The proportions of labeled neurons in the spinal cord hand region reflected the extent of cortical reactivation to the hand. Comparing monkeys with short and long recovery times suggests that the numbers of labeled neurons below the lesion increase with time following incomplete DCLs (<95%) but decrease with time after nearly complete DCLs (≥95%). Taken together, these results suggest that the second-order spinal cord pathway facilitates cortical reactivation, likely through the potentiation of persisting tactile inputs from the hand to the Cu over months of postlesion recovery.

Effects of Induced Hypothermia on Subcortical Evoked Potentials in the Cat

1958 ◽  
Vol 194 (2) ◽  
pp. 423-426 ◽  
Author(s):  
George C. Stevenson ◽  
William F. Collins ◽  
Clark T. Randt ◽  
Thomas D. Saurwein
Keyword(s):  
Spinal Cord ◽  
Evoked Potentials ◽  
Reticular Formation ◽  
Dorsal Column ◽  
Nerve Fibers ◽  
Induced Hypothermia ◽  
Conduction Time ◽  
Midbrain Reticular Formation ◽  
Spinal Cord Dorsal ◽  
Relay Nucleus

The effects of induced hypothermia in the unanesthetized immobilized cat on somatic afferent evoked potentials from the posteroventral lateral nucleus of the thalamus, periaqueductal midbrain reticular formation and dorsal column of the spinal cord were studied in 28 cats. At a rectal temperature of 23°C, marked depression of the responses recorded from all loci was demonstrable. The afferent midbrain reticular formation was demonstrated to be more sensitive to hypothermia than the thalamic relay nucleus. Augmentation of the spinal cord dorsal column evoked potentials was noted between 33°C and 25°C. Conduction time measurements indicated that between 37°C and 27°C the velocity of transmission along the nerve fibers is more affected than transmission across a synapse.

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