Chromosome analysis of two rat tumor cell lines possible role of DMs and HSR in metastasis

1984 ◽  
Vol 107 (3) ◽  
pp. 172-177 ◽  
Author(s):  
H. O. Werling ◽  
S. Ghosh ◽  
E. Spiess
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Chromosome Analysis ◽  
Tumor Cell Lines ◽  
Rat Tumor

Abstract B113: Role of I‐TAC‐binding receptors CXCR3 and CXCR7 in biology of various tumor cell lines

2009 ◽  
Author(s):  
Katarzyna Miekus ◽  
Danuta Jarocha ◽  
Elzbieta Trzyna ◽  
Marcin Majka
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Tumor Cell Lines

scholarly journals The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings.

2002 ◽  
Vol 49 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Maria M Bontemps-Gracz ◽  
Agnieszka Kupiec ◽  
Ippolito Antonini ◽  
Edward Borowski
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cell ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Human Tumor ◽  
Heterocyclic Ring ◽  
Tumor Cell Lines ◽  
Human Tumor Cell Lines

Two recently synthesized groups of acridine cytostatics containing fused heterocyclic ring(s): pyrazoloacridines (PAC) and pyrazolopyrimidoacridines (PPAC) were tested in regard to their in vitro cytotoxic activity towards a panel of sensitive and resistant human tumor cell lines. The obtained results corroborate our earlier hypothesis on the essential role of heterocyclic ring fused to the acridine moiety in the ability of acridine cytostatics to overcome multidrug resistance of tumor cells. The presence, location and kind of substituents considerably influenced both the cytotoxic activity of the derivatives and their ability to overcome multidrug resistance. The same factors also affected the cytostatics ability to differentiate between tumor cell lines with various types of drug exporting pumps.

The Role of Mitochondrial Hexokinase Binding in the Abnormal Energy Metabolism of Tumor Cell Lines

1986 ◽  
Vol 488 (1 Membrane Path) ◽  
pp. 438-450 ◽  
Author(s):  
RICHARD A. NAKASHIMA ◽  
LAURA J. SCOTT ◽  
PETER L. PEDERSEN
Keyword(s):  
Energy Metabolism ◽  
Tumor Cell ◽  
Cell Lines ◽  
Tumor Cell Lines

Role of apoptosis and apoptosis-related proteins in the cisplatin-resistant phenotype of human tumor cell lines

APOPTOSIS ◽  
1997 ◽  
Vol 2 (6) ◽  
pp. 540-548 ◽  
Author(s):  
P. Perego ◽  
S. C. Righetti ◽  
R. Supino ◽  
D. Delia ◽  
C. Caserini ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Resistant Phenotype ◽  
Related Proteins

Role of thymidine kinase in the inhibitory activity of 5-substituted-2'-deoxyuridines on the growth of human and murine tumor cell lines

1982 ◽  
Vol 31 (6) ◽  
pp. 1089-1095 ◽  
Author(s):  
J. Balzarini ◽  
E. De Clercq ◽  
P.F. Torrenc ◽  
M.P. Mertes ◽  
J.S. Park ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Thymidine Kinase ◽  
Cell Lines ◽  
Inhibitory Activity ◽  
Tumor Cell Lines ◽  
Murine Tumor

scholarly journals Decreased tumor surveillance in perforin-deficient mice.

1996 ◽  
Vol 184 (5) ◽  
pp. 1781-1790 ◽  
Author(s):  
M E van den Broek ◽  
D Kägi ◽  
F Ossendorp ◽  
R Toes ◽  
S Vamvakas ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Nk Cells ◽  
Mhc Class I ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Tumor Surveillance ◽  
Induced Tumors ◽  
Deficient Mice

Immune surveillance against tumors usually depends on T cell recognition of tumor antigens presented by major histocompatibility complex (MHC) molecules, whereas MHC class I- tumors may be controlled by natural killer (NK) cells. Perforin-dependent cytotoxicity is a major effector function of CD8+ MHC class I-restricted T cells and of NK cells. Here, we used perforin-deficient C57BL/6 (PKO) mice to study involvement of perforin and Fas ligand in tumor surveillance in vivo. We induced tumors in PKO and normal C57BL/6 mice by (a) injection of different syngeneic tumor cell lines of different tissue origin in naive and primed mice; (b) administration of the chemical carcinogens methylcholanthrene (MCA) or 12-O-tetradecanoylphorbol-13-acetate (TPA) plus 7,12-dimethylbenzanthracene (DMBA), or (c) by injection of acutely oncogenic Moloney sarcoma virus. The first set of models analyzes the defense against a tumor load given at once, whereas the last two sets give information on immune defense against tumors at the very moment of their generation. Most of the tumor cell lines tested were eliminated 10-100-fold better by C57BL/6 mice in an unprimed situation; after priming, the differences were more pronounced. Lymphoma cells transfected with Fas were controlled 10-fold better by PKO and C57BL/6 mice when compared to untransfected control cells, indicating some role for FasL in tumor control. MCA-induced tumors arose more rapidly and with a higher incidence in PKO mice compared to C57BL/6 or CD8-deficient mice. DMBA+TPA-induced skin papillomas arose with similar high incidence and comparable kinetics in both mouse strains. C57BL/6 and PKO mice have a similar incidence of Moloney murine sarcoma and leukemia virus-induced sarcomas, but tumors are larger and regression is retarded in PKO mice. Thus, perforin-dependent cytotoxicity is not only a crucial mechanism of both cytotoxic T lymphocyte- and NK-dependent resistance to injected tumor cell lines, but also operates during viral and chemical carcinogenesis in vivo. Experiments addressing the role of Fas-dependent cytotoxicity by studying resistance to tumor cell lines that were stably transfected with Fas neither provided evidence for a major role of Fas nor excluded a minor contribution of Fas in tumor surveillance.

PO-57 Antineoplastic role of enoxaparin in neuroectodermal tumor cell lines

2007 ◽  
Vol 120 ◽  
pp. S163
Author(s):  
N. Crescenzio ◽  
N. Bertorello ◽  
A. Doria ◽  
L. Foglia ◽  
P. Angelini ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Neuroectodermal Tumor ◽  
Tumor Cell Lines

Role of heat treatment in childhood cancers: Distinct resistance profiles of solid tumor cell lines towards combined thermochemotherapy

2005 ◽  
Vol 45 (5) ◽  
pp. 663-669 ◽  
Author(s):  
Anette Debes ◽  
Reinhart Willers ◽  
Ulrich Göbel ◽  
Rüdiger Wessalowski
Keyword(s):  
Heat Treatment ◽  
Tumor Cell ◽  
Cell Lines ◽  
Solid Tumor ◽  
Tumor Cell Lines ◽  
Childhood Cancers
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