Calculation of steady-state distributions of concentrations and potential controlled by diffusion and migration of ions

1991 ◽  
Vol 21 (6) ◽  
pp. 487-495 ◽  
Author(s):  
A. Katagiri
Keyword(s):  
Steady State ◽  
And Migration

scholarly journals Potential Anticancer Activity of Crude Ethanol, Ethyl Acetate, and Water Extracts of Ephedra foeminea on Human Osteosarcoma U2OS Cell Viability and Migration

2020 ◽  
Vol 2020 ◽  
pp. 1-16
Author(s):  
Eric Zadok Mpingirika ◽  
Ahmed El Hosseiny ◽  
Sheri Magdy Saleeb Bakheit ◽  
Rami Arafeh ◽  
Asma Amleh
Keyword(s):  
Steady State ◽  
Cell Viability ◽  
Ethyl Acetate ◽  
Anticancer Activity ◽  
Ethanol Extract ◽  
U2os Cell ◽  
Mrna Levels ◽  
Water Extracts ◽  
Human Osteosarcoma ◽  
And Migration

Medicinal plants are potential sources for a wide range of complex compounds with probable anticancer activity. Ephedra foeminea Forssk. (E. foeminea), a medicinal plant found in the Eastern Mediterranean, has recently been gaining popularity as a cancer remedy; there is, however, a paucity of empirical evidence supporting this claim. In this study, the effect of E. foeminea ethyl acetate, ethanol, and water crude extracts on viability, migratory ability, and the steady-state mRNA levels of genes involved in these processes was, respectively, examined using MTT assay, wound healing assay, and reverse transcriptase PCR (RT-PCR). The study concludes that all extracts significantly reduce human osteosarcoma U2OS percentage viability in a dose- and time-dependent manner, with varying potencies. The least half-maximal inhibitory concentration (IC50) was observed in the water extract after 48 h incubation (30.761±1.4 μg/mL) followed by the ethyl acetate extract after 72 h incubation (80.35±1.233 μg/mL) and finally the ethanol extract after 48 h incubation (97.499±1.188 μg/mL). Ethanol extract significantly reduced U2OS percentage wound closure. On the other hand, both ethanol and water extracts considerably reduced the steady-state mRNA expression of beta-catenin, promoting both cell proliferation and migration in osteosarcoma by regulating target genes. Additionally, E. foeminea showed no hemolytic activity. These effects suggest that E. foeminea decreases U2OS cell viability and migratory ability by modulating the expression of critical genes involved in regulating these processes and is likely cytocompatible with human erythrocytes.

FORCE ON A DROPLET IN ANOTHER LIQUID WITH ARBITRARY ARRANGEMENT OF THE GRAVITY AND THERMAL GRADIENT

2005 ◽  
Vol 19 (28n29) ◽  
pp. 1671-1674
Author(s):  
REN SUN
Keyword(s):  
Gravitational Field ◽  
Steady State ◽  
General Solution ◽  
Physical Properties ◽  
Thermal Gradient ◽  
Droplet Cluster ◽  
And Migration ◽  
State Force

The steady-state force on the droplet released in another liquid subjected to the gravitational field and imposed thermal gradient in the case of vanishingly small Re and Ma is derived using the general solution given by Lamb. A solution to a transitional thermocapillary-type droplet migration is thereby obtained for the case of constant physical properties, which corresponds to the well known YGB result as t → ∞. These can be employed to investigate the interactions between droplets in a host solution under the gravitational and thermal influences, and further to explore deposition and migration of a droplet cluster in the corresponding fields.

Hemodynamics in stenotic vessels of small diameter under steady state conditions: Effect of viscoelasticity and migration of red blood cells

Biorheology ◽  
2015 ◽  
Vol 52 (3) ◽  
pp. 183-210 ◽  
Author(s):  
Yannis Dimakopoulos ◽  
George Kelesidis ◽  
Sophia Tsouka ◽  
Georgios C. Georgiou ◽  
John Tsamopoulos
Keyword(s):  
Steady State ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Small Diameter ◽  
And Migration

scholarly journals Neutrophils instruct homeostatic and pathological states in naive tissues

2018 ◽  
Vol 215 (11) ◽  
pp. 2778-2795 ◽  
Author(s):  
Maria Casanova-Acebes ◽  
José A. Nicolás-Ávila ◽  
Jackson LiangYao Li ◽  
Susana García-Silva ◽  
Akhila Balachander ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Steady State ◽  
Pulmonary Vasculature ◽  
Immune Protection ◽  
Organ Function ◽  
Tissue Specific ◽  
Diurnal Patterns ◽  
And Migration ◽  
Circadian Transcription ◽  
Bone Marrow Niches

Immune protection relies on the capacity of neutrophils to infiltrate challenged tissues. Naive tissues, in contrast, are believed to remain free of these cells and protected from their toxic cargo. Here, we show that neutrophils are endowed with the capacity to infiltrate multiple tissues in the steady-state, a process that follows tissue-specific dynamics. By focusing in two particular tissues, the intestine and the lungs, we find that neutrophils infiltrating the intestine are engulfed by resident macrophages, resulting in repression of Il23 transcription, reduced G-CSF in plasma, and reinforced activity of distant bone marrow niches. In contrast, diurnal accumulation of neutrophils within the pulmonary vasculature influenced circadian transcription in the lungs. Neutrophil-influenced transcripts in this organ were associated with carcinogenesis and migration. Consistently, we found that neutrophils dictated the diurnal patterns of lung invasion by melanoma cells. Homeostatic infiltration of tissues unveils a facet of neutrophil biology that supports organ function, but can also instigate pathological states.

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