Vanadate inhibition of rat cerebral cortex Na+, K+-ATPase during postnatal development

1987 ◽  
Vol 12 (6) ◽  
pp. 537-540 ◽  
Author(s):  
Jaroslava Folbergrová ◽  
Pavel Mareš
Keyword(s):  
Cerebral Cortex ◽  
Postnatal Development ◽  
Rat Cerebral Cortex ◽  
Vanadate Inhibition

scholarly journals Postnatal changes in dolichol-pathway enzyme activities in cerebral cortex neurons

1982 ◽  
Vol 202 (1) ◽  
pp. 87-95 ◽  
Author(s):  
V Idoyaga-Vargas ◽  
H Carminatti
Keyword(s):  
Cerebral Cortex ◽  
Postnatal Development ◽  
Enzyme Activities ◽  
Synapse Formation ◽  
Adult Stage ◽  
Protein S ◽  
Rat Cerebral Cortex ◽  
Dolichyl Phosphate ◽  
Endogenous Protein ◽  
Dolichol Pathway

Neuronal perikarya were isolated from rat cerebral cortex at different stages of postnatal development. Membranes sedimenting at 100000 g were obtained from these neurons to study several glycosyltransferases of the dolichol pathway. Enzyme activities from stages before and during synapse formation were compared (days 5 and 15 respectively). Dolichyl diphosphate (Dol-P-P) N-acetylglucosamine, dolichyl phosphate mannose and dolichyl phosphate glucose synthases and the enzymes catalysing Dol-P-P-GlcNAc2Man9Glc3 formation were higher at day 15 of postnatal development. The glycosyl transfer of the latter compound to endogenous protein(s) as well as to a dinitrophenyl-heptapeptide was also measured. The activity was higher at day 15. Furthermore, the activity of dolichyl phosphate mannose synthase was also measured during the time when the number of synapses ceased to increase (day 36) and in the adult stage. The activity of dolichyl phosphate mannose synthase was higher at day 36 than at day 15, and declined in the adult stage. From these results it may be concluded that there is an increase in the glycosylation of asparagine-type glycoproteins during synapse formation in the neurons of the cerebral cortex.

scholarly journals Glutamatergic and GABAergic Neurotransmitter Cycling and Energy Metabolism in Rat Cerebral Cortex during Postnatal Development

2007 ◽  
Vol 27 (12) ◽  
pp. 1895-1907 ◽  
Author(s):  
Golam MI Chowdhury ◽  
Anant B Patel ◽  
Graeme F Mason ◽  
Douglas L Rothman ◽  
Kevin L Behar
Keyword(s):  
Cerebral Cortex ◽  
Energy Metabolism ◽  
Postnatal Development ◽  
Rat Cerebral Cortex
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