Simultaneous double-isotope autoradiographic measurement of local cerebral glucose metabolic rate and acid-base status in rat brain

1987 ◽  
Vol 2 (1) ◽  
pp. 47-60 ◽  
Author(s):  
Alan H. Lockwood ◽  
Kathryn E. Peek ◽  
Marc Berridge ◽  
Linda Bogue ◽  
Eddy Yap
Keyword(s):  
Metabolic Rate ◽  
Rat Brain ◽  
Acid Base ◽  
Glucose Metabolic Rate ◽  
Acid Base Status ◽  
Double Isotope

scholarly journals Recovery from Anaerobiosis in the Intertidal Worm Sipunculus Nudus: II. Gas Exchange and Changes in the Intra- and Extracellular Acid-Base Status

1986 ◽  
Vol 122 (1) ◽  
pp. 51-64
Author(s):  
H. O. PÖRTNER ◽  
S. VOGELER ◽  
M. K. GRIESHABER
Keyword(s):  
Gas Exchange ◽  
Metabolic Rate ◽  
Time Course ◽  
The Body ◽  
Coelomic Fluid ◽  
Acid Base ◽  
Extracellular Acidosis ◽  
Sipunculus Nudus ◽  
Acid Base Status ◽  
Negative Base

Intra- and extracellular acid-base status and changes of coelomic PCOCO2 were investigated during recovery following 24 h of anaerobiosis in Sipunculus nudus L. Metabolism, gas exchange and acid-base status were compared in animals collected during March and October. Anaerobiosis led to an uncompensated metabolic acidosis, the degree of the acidosis depending on the metabolic rate of the animals. During initial recovery in March animals, the acidosis was transiently aggravated in the extracellular, but not in the intracellular, compartment, indicating an efficient regulation of intracellular pH as soon as oxygen was available in the coelomic fluid. The extracellular acidosis was predominantly of non-respiratory origin. The non-respiratory part of the acidosis is attributed to the repletion of the phospho-l-arginine pool. The proton yield calculated from phosphagen resynthesis was highly correlated in time and in quantity to the observed negative base excess in the extracellular compartment. In October animals, strombine accumulation may have contributed to the acidosis that develops during recovery. The amount of succinate, propionate, and acetate in the coelomic plasma had already decreased when the acidosis developed. This discrepancy supports the conclusion that protons move between the body compartments independent of the distribution of anionic metabolites. The respiratory part of the acidosis is attributed to the repayment of an oxygen debt. The increase of PCOCO2 is higher in October than in March animals, probably because of differences in metabolic rate The time course of acid-base disturbances and their compensation is discussed in relation to the time course of metabolic events during recovery and to the priorities of the different processes observed.

To Manage Infantile Hypertrophic Pyloric Stenosis by "Double-Y Pyloromyotomy" is a better Surgical Approach

2014 ◽  
Vol 1 (2) ◽  
pp. 143-147
Author(s):  
Md. Ansar Ali ◽  
Kaniz Hasina ◽  
Shahnoor Islam ◽  
Md. Ashraf Ul Huq ◽  
Md. Mahbub-Ul Alam ◽  
...  
Keyword(s):  
Weight Gain ◽  
Pyloric Stenosis ◽  
Hypertrophic Pyloric Stenosis ◽  
Treatment Modalities ◽  
Infantile Hypertrophic Pyloric Stenosis ◽  
Postoperative Vomiting ◽  
Acid Base ◽  
Feeding Regimes ◽  
Acid Base Status ◽  
Postoperative Feeding

Background: Different treatment modalities and procedures have been tried for the management of infantile hypertrophic pyloric stenosis. But surgery remains the mainstay for management of IHPS. Ramstedt’s pyloromyotomy was described almost over a hundred years ago and to date remains the surgical technique of choice. An alternative and better technique is the double-Y pyloromyotomy, which offer better results for management of this common condition.Methods: A prospective comparative interventional study of 40 patients with IHPS was carried out over a period of 2 years from July 2008 to July 2010. The patients were divided into 2 equal groups of 20 patients in each. The study was designed that all patients selected for study were optimized preoperatively regarding to hydration, acid-base status and electrolytes imbalance. All surgeries were performed after obtaining informed consent. Standard preoperative preparation and postoperative feeding regimes were used. The patients were operated on an alternate basis, i.e., one patient by Double-Y Pyloromyotomy(DY) and the next by aRamstedt’s Pyloromyotomy (RP). Data on patient demographics, operative time, anesthesia complications, postoperative complications including vomiting and weight gain were collected. Patients were followed up for a period of 3 months postoperatively. Statistical assessments were done by using t test.Results: From July 2008 through July 2010, fourty patients were finally analyzed for this study. Any statistical differences were observed in patient population regarding age, sex, weight at presentation, symptoms and clinical condition including electrolytes imbalance and acid-base status were recorded. Significant differences were found in postoperative vomiting and weight gain. Data of post operative vomiting and weight gain in both groups were collected. Vomiting in double-Y(DY) pyloromyotomy group (1.21 ± 0.45days) vs Ramstedt’s pyloromyotomy (RP) group(3.03 ± 0.37days) p= 0.0001.Weight gain after 1st 10 days DY vs RP is ( 298 ± 57.94 gm vs193±19.8 gm p=0.0014), after 1 month (676.67±149.84 gm vs 466.67 ± 127.71 gm, p=0.0001), after 2months (741.33± 278.74 gm vs 490±80.62 gm, p=0.002) and after 3 months (582±36.01gm vs 453.33±51.64 gm, p=0.0001).No long-term complications were reported and no re-do yloromyotomy was needed.Conclusion: The double-Y pyloromyotomy seems to be a better technique for the surgical management of IHPS. It may offer a better functional outcome in term of postoperative vomiting and weight gain.DOI: http://dx.doi.org/10.3329/jpsb.v1i2.19532

The oxygen- and acid-base status during hypothermic cardiopulmonary bypass

1988 ◽  
Vol 48 ◽  
pp. 63-71 ◽  
Author(s):  
Ivar Gøthgen ◽  
Ole Siggaard-Andersen ◽  
Jens Rasmussen ◽  
Peter Wimberley ◽  
Niels Fogh. Andersen
Keyword(s):  
Cardiopulmonary Bypass ◽  
Acid Base ◽  
Hypothermic Cardiopulmonary Bypass ◽  
Acid Base Status
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