Developmental inhibition ofSpodoptera litura (Fab.) larvae by a novel caffeoylquinic acid from the wild groundnut,Arachis paraguariensis (Chod et Hassl.)

1993 ◽  
Vol 19 (12) ◽  
pp. 2917-2933 ◽  
Author(s):  
P. C. Stevenson ◽  
J. C. Anderson ◽  
W. M. Blaney ◽  
M. S. J. Simmonds
2008 ◽  
Vol 36 (4) ◽  
pp. 312-315 ◽  
Author(s):  
Suzana G. Leitão ◽  
Eduardo N. da Fonseca ◽  
Tereza Cristina dos Santos ◽  
Flavio França ◽  
Franco Delle Monache

2012 ◽  
Vol 60 (22) ◽  
pp. 5597-5603 ◽  
Author(s):  
Sang Min Kim ◽  
Je-Seung Jeon ◽  
Suk Woo Kang ◽  
Yu-Jin Jung ◽  
Lin Na Ly ◽  
...  
Keyword(s):  

2021 ◽  
pp. 138
Author(s):  
Ratu Wifaira Azzahra ◽  
Niky Murdaya ◽  
Adnan Aly Al Shofwan ◽  
Erlangga Ramadan ◽  
Savira Dwi Utami

Inflamasi merupakan reaksi alami tubuh untuk melindungi diri dari patogen menyebab penyakit. Interleukin-6 (IL-6) berperan sebagai sitokin pro-inflamasi dan antiinflamasi yang dikeluarkan oleh sel T dan makrofag untuk merangsang respon imun saat terjadi infeksi. Pada penelitian ini, dilakukan studi in silico ekstrak etanol daun kenikir (Cosmos caudatus) sebagai anti-inflamasi yang didasarkan pada afinitas terhadap Interleukin-6 (IL-6) dengan menggunakan metode molecular docking secara in silico. Penelitian ini meliputi simulasi penambatan molekuler kandungan senyawa ekstrak etanol daun kenikir terhadap reseptor IL-6 (PDB ID : 1ALU) dan prediksi profil farmakokinetik dan toksisitas menggunakan server Pre-ADMET. Hasil penelitian menunjukkan bahwa diperoleh empat senyawa potensial, yaitu C1 (Kaempferol), C2 (1-Caffeoylquinic acid, C3 (Procyanidin B1), dan C5 (Quercetin-3-O-pentoside).Keempat senyawa tersebut memiliki nilai ?G dan Ki yang lebih baik dibandingkan dengan ligan alami. Nilai ?G; Ki senyawa uji tersebut, yaitu berturut-turut (-5,29 Kkal/mol; 133,31 uM), (-6,02 Kkal/mol; 38,44 uM), (-5,38 Kkal/mol; 114,24 uM), dan (-5,46 Kkal/mol; 99,50 uM). Hasil PreADMET keempat senyawa tersebut memiliki daya adsorpsi yang baik sehingga dapat dipertimbangkan dalam pembuatan sediaan rute oral. Hasil ames test menunjukkan bahwa C1 dan C2 bersifat mutagenik, sedangkan C3 dan C4 non mutagenik.


2003 ◽  
Vol 128 (2) ◽  
pp. 182-187 ◽  
Author(s):  
Md. Shahidul Islam ◽  
Makoto Yoshimoto ◽  
Koji Ishiguro ◽  
Shigenori Okuno ◽  
Osamu Yamakawa

The phenolic content and the radical scavenging activity were compared in leaves of sweetpotato (Ipomoea batatas L.) cultivars Shimon-1, Kyushu-119 and Elegant Summer grown under different temperature and shading conditions. Compared to cultivar differences, there was less effect of temperature and shading on the total phenolic content in sweetpotato leaves, however certain polyphenolic components differed widely among the treatments. The positive correlation between the radical scavenging activity and the level of total phenolics (r = 0.62) suggests that phenolic compounds are important antioxidant components of sweetpotato leaves. All the reverse-phase high-performance liquid chromatography (RP-HPLC) profiles of the cultivars tested showed peaks at the same retention times but peak areas of individual phenolic compounds differed with respective temperature and shading treatments. The phenolic compounds identified in the sweetpotato leaf were caffeic acid, chlorogenic acid, 4,5-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, 3,4-di-O-caffeoylquinic acid, and 3,4,5-tri-O-caffeoylquinic acid. Most of the phenolic compounds were highest in leaves from plants grown at 20 °C without shading except 4,5-di-O-caffeoylquinic acid. The results indicate that growing leaves under moderately high temperatures and in full sun enhances the accumulation of phenolic components. These phenolic components have possible value in enhancing human health.


2012 ◽  
Vol 03 (05) ◽  
pp. 567-571 ◽  
Author(s):  
Olubunmi Aina ◽  
Kenneth Quesenberry ◽  
Maria Gallo

Planta Medica ◽  
1986 ◽  
Vol 52 (06) ◽  
pp. 529-530 ◽  
Author(s):  
M. Puigmaciá ◽  
T. Adzet ◽  
M Ruviralta ◽  
J. Iglesias

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