High-affinity [3H]inositol uptake by dissociated brain cells and cultured fibroblasts from fetal mice

1991 ◽  
Vol 16 (8) ◽  
pp. 913-918 ◽  
Author(s):  
B. R. Fruen ◽  
B. R. Lester
Keyword(s):  
Brain Cells ◽  
Cultured Fibroblasts ◽  
High Affinity ◽  
Fetal Mice ◽  
Dissociated Brain Cells ◽  
Inositol Uptake

Down-regulation of free intracellular calcium in dissociated brain cells of aged mice and rats

Life Sciences ◽  
1996 ◽  
Vol 59 (5-6) ◽  
pp. 435-449 ◽  
Author(s):  
Henrike Hartmann ◽  
Anne Eckert ◽  
Karsten Velbinger ◽  
Michael Rewsin ◽  
Walter E. Müller
Keyword(s):  
Intracellular Calcium ◽  
Brain Cells ◽  
Down Regulation ◽  
Aged Mice ◽  
Free Intracellular Calcium ◽  
Dissociated Brain Cells

Effects of lithium on morphological characteristics of dissociated brain cells in culture

1979 ◽  
Vol 46 (1-2) ◽  
pp. 117-121 ◽  
Author(s):  
Z. Janka ◽  
I. Szentistv�nyi ◽  
F. Joo ◽  
A. Juh�sz ◽  
�. Riman�czy
Keyword(s):  
Morphological Characteristics ◽  
Brain Cells ◽  
Cells In Culture ◽  
Dissociated Brain Cells

Steady-state distribution of lithium during cultivation of dissociated brain cells

1980 ◽  
Vol 36 (9) ◽  
pp. 1071-1072 ◽  
Author(s):  
Z. Janka ◽  
I. Szentistványi ◽  
A. Juhász ◽  
A. Rimanóczy
Keyword(s):  
Steady State ◽  
Brain Cells ◽  
Steady State Distribution ◽  
State Distribution ◽  
Dissociated Brain Cells

Investigations on myelination in vitro: Biochemical and morphological changes in cultures of dissociated brain cells from embryonic mice

1980 ◽  
Vol 189 (1) ◽  
pp. 79-90 ◽  
Author(s):  
Louis L. Sarlieve ◽  
G. Subba Rao ◽  
Graham LeM. Campbell ◽  
Ronald A. Pieringer
Keyword(s):  
Morphological Changes ◽  
Brain Cells ◽  
Dissociated Brain Cells

scholarly journals Down's syndrome fibroblasts exhibit enhanced inositol uptake

1990 ◽  
Vol 270 (1) ◽  
pp. 119-123 ◽  
Author(s):  
B R Fruen ◽  
B R Lester
Keyword(s):  
Plasma Membrane ◽  
Kinetic Analysis ◽  
Trisomy 21 ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Maximal Velocity ◽  
High Affinity ◽  
Proportional Increase ◽  
Inositol Uptake ◽  
Inositol Metabolism

The inositol metabolism of Down's syndrome (DS, trisomy 21) skin fibroblasts was examined. We report that DS cells accumulated [3H]inositol 2-3-fold faster than did other aneuploid or diploid controls. In contrast, trisomy 21 did not affect the uptake of choline, serine or glucose. Kinetic analysis demonstrated an increased maximal velocity of high-affinity, Na(+)-dependent, inositol transport, consistent with the expression of higher numbers of transporters by DS cells. Enhanced uptake was accompanied by a proportional increase in the incorporation of radiolabelled inositol into phospholipid. We suggest that an imbalance of inositol metabolism may contribute to plasma membrane abnormalities characteristic of DS cells.

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