Superoxide dismutase activity in rat brain during acute and chronic alcohol intoxication

1981 ◽  
Vol 6 (4) ◽  
pp. 385-390 ◽  
Author(s):  
Marc Ledig ◽  
Jean-R�my M'Paria ◽  
Paul Mandel
Keyword(s):  
Superoxide Dismutase ◽  
Rat Brain ◽  
Alcohol Intoxication ◽  
Superoxide Dismutase Activity ◽  
Chronic Alcohol ◽  
Chronic Alcohol Intoxication

scholarly journals Neurotransmitter disturbances in some parts of the rat brain and their correction under chronic and intermittent alcohol intoxication

2019 ◽  
Vol 65 (1) ◽  
pp. 21-27 ◽  
Author(s):  
V.K. Gushcha ◽  
S.V. Lelevich ◽  
V.M. Sheibak
Keyword(s):  
Amino Acids ◽  
Rat Brain ◽  
Alcohol Intoxication ◽  
Chronic Alcohol ◽  
Neurotransmitter Amino Acids ◽  
Chronic Alcohol Intoxication ◽  
Dihydroxyphenylacetic Acid ◽  
Amino Acids Composition

The pool of key neuromediators and some neurotransmitter amino acids in cerebellum, hypothalamus and midbrain of rats exposed to chronic and different variants of interrupted alcohol intoxication was investigated. The most pronounced changes were recorded in midbrain. Chronic alcohol intoxication caused an increase in the concentrations of tyrosine, dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), noradrenaline, tryptophan, serotonin, GABA and aspartate in this part of the rat brain. Interrupted alcohol intoxication with 4 days interval is accompanied by an increase in the content of tyrosine, and noradrenaline. Interrupted alcohol intoxication with 1 day interval leaded to an increase in the concentrations of tyrosine, DOPAC, noradrenalin, tryptophan, GABA, glycine and aspartate. The amino acids composition “Titacin” had a pronounced normalizing effect in the midbrain under interrupted alcohol intoxication with 1 day interval.

Features of the sensitivity of the central nervous system of the organism of experimental animals to the effects of certain psychotropic drugs and their combinations against the background of chronic alcohol intoxication in a chronopharmacological experiment

2020 ◽  
pp. 56-62
Author(s):  
E.V. Filippova
Keyword(s):  
Alcohol Intoxication ◽  
Laboratory Animals ◽  
Histological Structure ◽  
Chronic Alcohol ◽  
Behavioral Reactions ◽  
Experimental Animals ◽  
Chronic Alcohol Intoxication ◽  
Psychotropic Action ◽  
Adaptive Effect ◽  
The Central Nervous System

In a chronopharmacological experiment, the effect of two drugs with psychotropic action in combinations on the behavior of laboratory animals subjected to chronic alcohol intoxication was examined. Against the background of a deprimating agent, a decrease in the threshold of sensitivity to electrical irritation and the duration of an aggressive reaction was revealed; an increase in these indicators was established with a combination of a deprimating drug with an antioxidant. It has been shown that the antioxidant has a desynchronizing effect on the behavioral reactions of laboratory animals for two days, which indicates a pronounced adaptive effect. In the case of using combinations of a deprimating agent with an antioxidant, a decrease in the destruction of the histological structure of the myocardium against the background of chronic alcoholization was established.

scholarly journals The effect of chronic alcohol intoxication and smoking on the output of salivary immunoglobulin A

2012 ◽  
Vol 50 (4) ◽  
pp. 605-608 ◽  
Author(s):  
Napoleon Waszkiewicz ◽  
Anna Zalewska ◽  
Slawomir Dariusz Szajda ◽  
Magdalena Waszkiewicz ◽  
Agata Szulc ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Immunoglobulin A ◽  
Chronic Alcohol ◽  
Chronic Alcohol Intoxication ◽  
Salivary Immunoglobulin A

scholarly journals Nervous system injury in alcoholic disease

2019 ◽  
Vol 11 (2S) ◽  
pp. 83-88
Author(s):  
O. E. Zinovyeva ◽  
N. V. Vashchenko ◽  
O. E. Mozgovaya ◽  
T. A. Yanakaeva ◽  
A. Yu. Emelyanova
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Alcohol Intoxication ◽  
Clinical Manifestations ◽  
Symptomatic Treatment ◽  
Chronic Alcohol ◽  
Neurological Manifestations ◽  
Chronic Alcohol Intoxication ◽  
Alcoholic Disease

The paper considers various variants of nervous system injury in alcoholic disease. It discusses the epidemiology, pathogenesis, diagnosis, and clinical manifestations of central and peripheral nervous system lesions in the presence of acute and chronic alcohol intoxication. Attention is paid to the issues of etiotropic, pathogenetic, and symptomatic treatment for neurological manifestations of alcoholic disease and to the role of neurotropic B vitamins in the treatment of alcohol-induced deficiency and non-deficiency states.

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